LIF

LIF
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1EMR, 1PVH, 2Q7N
Dynodwyr
Cyfenwau	LIF, CDF, DIA, HILDA, MLPLI, leukemia inhibitory factor, interleukin 6 family cytokine, LIF interleukin 6 family cytokine
Dynodwyr allanol	OMIM: 159540 HomoloGene: 1734 GeneCards: LIF
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • signaling receptor binding • growth factor activity • cytokine activity • GO:0001948, GO:0016582 protein binding • leukemia inhibitory factor receptor binding Cydrannau o'r gell • extracellular region • extracellular space • cytosol Prosesau biolegol • negative regulation of cell population proliferation • stem cell differentiation • positive regulation of peptidyl-serine phosphorylation of STAT protein • positive regulation of MAPK cascade • positive regulation of peptidyl-serine phosphorylation • spongiotrophoblast differentiation • lung development • positive regulation of histone H3-K27 acetylation • multicellular organism development • lung lobe morphogenesis • muscle organ morphogenesis • maternal process involved in female pregnancy • negative regulation of hormone secretion • leukemia inhibitory factor signaling pathway • regulation of metanephric nephron tubule epithelial cell differentiation • regulation of cell differentiation • GO:1901313 positive regulation of gene expression • stem cell population maintenance • positive regulation of peptidyl-tyrosine phosphorylation • regulation of RNA polymerase II regulatory region sequence-specific DNA binding • positive regulation of astrocyte differentiation • negative regulation of ERK1 and ERK2 cascade • neuron development • decidualization • positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis • lung alveolus development • positive regulation of macrophage differentiation • blood vessel remodeling • trophoblast giant cell differentiation • lung vasculature development • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • positive regulation of protein localization to nucleus • embryo implantation • negative regulation of meiotic nuclear division • GO:0046730, GO:0046737, GO:0046738, GO:0046736 immune response • positive regulation of cell population proliferation • positive regulation of tyrosine phosphorylation of STAT protein • tyrosine phosphorylation of STAT protein • regulation of signaling receptor activity • cytokine-mediated signaling pathway Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	3976	n/a
Ensembl	ENSG00000128342	n/a
UniProt	P15018	n/a
RefSeq (mRNA)	NM_001257135 NM_002309	n/a
RefSeq (protein)	NP_001244064 NP_002300	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn LIF yw LIF a elwir hefyd yn LIF, interleukin 6 family cytokine (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 22, band 22q12.2.^[2]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn LIF.

• "The Multifaceted Actions of Leukaemia Inhibitory Factor in Mediating Uterine Receptivity and Embryo Implantation. ". Am J Reprod Immunol. 2016. PMID 26817565.
• "Integrin αVβ3 and αVβ5 are required for leukemia inhibitory factor-mediated the adhesion of trophoblast cells to the endometrial cells. ". Biochem Biophys Res Commun. 2016. PMID 26723254.
• "Leukemia inhibitory factor promotes EMT through STAT3-dependent miR-21 induction. ". Oncotarget. 2016. PMID 26716902.
• "Association between leukaemia inhibitory factor gene polymorphism and pregnancy outcomes after assisted reproduction techniques. ". Reprod Biomed Online. 2016. PMID 26615902.
• "Leukemia inhibitory factor promotes tumor growth and metastasis in human osteosarcoma via activating STAT3.". APMIS. 2015. PMID 26271643.