IRF2

IRF2
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1IRF, 1IRG, 2IRF
Dynodwyr
Cyfenwau	IRF2, IRF-2, interferon regulatory factor 2
Dynodwyr allanol	OMIM: 147576 HomoloGene: 1659 GeneCards: IRF2
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • DNA binding • RNA polymerase II transcription regulatory region sequence-specific DNA binding • GO:0001948, GO:0016582 protein binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Cydrannau o'r gell • cnewyllyn cell • focal adhesion • nucleoplasm • cytosol Prosesau biolegol • interferon-gamma-mediated signaling pathway • cell population proliferation • blood coagulation • GO:0009373 regulation of transcription, DNA-templated • GO:1901227 negative regulation of transcription by RNA polymerase II • type I interferon signaling pathway • transcription, DNA-templated • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • transcription by RNA polymerase II • immune system process Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	3660	n/a
Ensembl	ENSG00000168310	n/a
UniProt	P14316	n/a
RefSeq (mRNA)	NM_002199	n/a
RefSeq (protein)	NP_002190	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn IRF2 yw IRF2 a elwir hefyd yn Interferon regulatory factor 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 4, band 4q35.1.^[2]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn IRF2.

• IRF-2

• "Upregulation of microRNA-450 inhibits the progression of lung cancer in vitro and in vivo by targeting interferon regulatory factor 2. ". Int J Mol Med. 2016. PMID 27246609.
• "Association of functional polymorphisms in interferon regulatory factor 2 (IRF2) with susceptibility to systemic lupus erythematosus: a case-control association study. ". PLoS One. 2014. PMID 25285625.
• "Variants in the interferon regulatory factor-2 gene are not associated with pancreatitis in Japan. ". Pancreas. 2014. PMID 25207663.
• "IRF-2 is over-expressed in pancreatic cancer and promotes the growth of pancreatic cancer cells. ". Tumour Biol. 2012. PMID 22119988.
• "Genetic variants in interferon regulatory factor 2 (IRF2) are associated with atopic dermatitis and eczema herpeticum.". J Invest Dermatol. 2012. PMID 22113474.