HMGCR

HMGCR
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1DQ8, 1DQ9, 1DQA, 1HW8, 1HW9, 1HWI, 1HWJ, 1HWK, 1HWL, 2Q1L, 2Q6B, 2Q6C, 2R4F, 3BGL, 3CCT, 3CCW, 3CCZ, 3CD0, 3CD5, 3CD7, 3CDA, 3CDB
Dynodwyr
Cyfenwau	HMGCR, HMG-CoA reductase, Entrez 3156, LDLCQ3, 3-hydroxy-3-methylglutaryl-CoA reductase, Hydroxymethylglutaryl-CoA reductase
Dynodwyr allanol	OMIM: 142910 HomoloGene: 30994 GeneCards: HMGCR
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0050229 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor • protein homodimerization activity • hydroxymethylglutaryl-CoA reductase (NADPH) activity • GO:0001948, GO:0016582 protein binding • NADP binding • NADPH binding • oxidoreductase activity • protein phosphatase 2A binding Cydrannau o'r gell • integral component of membrane • endoplasmic reticulum membrane • bilen • intracellular membrane-bounded organelle • peroxisomal membrane • Reticwlwm endoplasmig Prosesau biolegol • visual learning • steroid metabolic process • sterol biosynthetic process • negative regulation of striated muscle cell apoptotic process • coenzyme A metabolic process • response to nutrient • positive regulation of skeletal muscle tissue development • lipid metabolism • positive regulation of cardiac muscle cell apoptotic process • negative regulation of insulin secretion involved in cellular response to glucose stimulus • GO:0010260 heneiddio • negative regulation of apoptotic process • cholesterol metabolic process • protein tetramerization • isoprenoid biosynthetic process • negative regulation of MAP kinase activity • positive regulation of cell population proliferation • positive regulation of ERK1 and ERK2 cascade • negative regulation of wound healing • ubiquinone metabolic process • myoblast differentiation • response to ethanol • positive regulation of stress-activated MAPK cascade • positive regulation of smooth muscle cell proliferation • steroid biosynthetic process • regulation of lipid metabolic process • regulation of cholesterol biosynthetic process • cholesterol biosynthetic process • GO:1903363 negative regulation of protein catabolic process • negative regulation of protein secretion • negative regulation of amyloid-beta clearance Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	3156	n/a
Ensembl	ENSG00000113161	n/a
UniProt	P04035	n/a
RefSeq (mRNA)	NM_000859 NM_001130996 NM_001364187	n/a
RefSeq (protein)	NP_000850 NP_001124468 NP_001351116 NP_000850.1	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn HMGCR yw HMGCR a elwir hefyd yn 3-hydroxy-3-methylglutaryl-coenzyme A reductase , 3-hydroxy-3-methylglutaryl coenzyme A reductase , 3-hydroxy-3-methylglutaryl-CoA reductase a 3-hydroxy-3-methylglutaryl-coenzyme A reductase (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 5, band 5q13.3.^[2]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn HMGCR.

• LDLCQ3

• "Natural Inhibitors of HMG-CoA Reductase-An Insilico Approach Through Molecular Docking and Simulation Studies. ". J Cell Biochem. 2017. PMID 27216569.
• "HMGCR is up-regulated in gastric cancer and promotes the growth and migration of the cancer cells. ". Gene. 2016. PMID 27085483.
• "Association of HMGCR polymorphism with late-onset Alzheimer's disease in Han Chinese. ". Oncotarget. 2016. PMID 27009838.
• "Effect of HMGCR genetic variation on neuroimaging biomarkers in healthy, mild cognitive impairment and Alzheimer's disease cohorts. ". Oncotarget. 2016. PMID 26950278.
• "Effects of rs3846662 Variants on HMGCR mRNA and Protein Levels and on Markers of Alzheimer's Disease Pathology.". J Mol Neurosci. 2016. PMID 26541602.