DDX3X

DDX3X
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2I4I, 2JGN, 3JRV, 4O2C, 4O2E, 4O2F, 4PX9, 4PXA, 5E7J, 5E7M, 5E7I
Dynodwyr
Cyfenwau	DDX3X, DBX, DDX14, DDX3, HLP2, CAP-Rf, MRX102, DEAD-box helicase 3, X-linked, DEAD-box helicase 3 X-linked, MRXSSB
Dynodwyr allanol	OMIM: 300160 HomoloGene: 3425 GeneCards: DDX3X
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • DNA binding • nucleotide binding • nucleoside-triphosphatase activity • CTPase activity • GO:0008026 helicase activity • poly(A) binding • ribosomal small subunit binding • RNA stem-loop binding • GO:0004003 DNA helicase activity • transcription factor binding • ATPase activity • GO:0001948, GO:0016582 protein binding • GO:0006184 GTPase activity • eukaryotic initiation factor 4E binding • RNA binding • nucleic acid binding • mRNA 5'-UTR binding • translation initiation factor binding • hydrolase activity • ATP binding • RNA strand annealing activity • cadherin binding • protein serine/threonine kinase activator activity Cydrannau o'r gell • cytoplasm • eukaryotic translation initiation factor 3 complex • nuclear speck • bilen • mitochondrial outer membrane • cytosolic small ribosomal subunit • mitocondria • cytoplasmic stress granule • extracellular exosome • cnewyllyn cell • extracellular region • cytosol • secretory granule lumen • ficolin-1-rich granule lumen • nucleolus Prosesau biolegol • stress granule assembly • GO:0097285 apoptotic process • negative regulation of translation • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process • GO:0007243 intracellular signal transduction • GO:0009373 regulation of transcription, DNA-templated • ribosome biogenesis • negative regulation of intrinsic apoptotic signaling pathway • immune system process • chromosome segregation • GO:0106160 negative regulation of protein-containing complex assembly • response to virus • negative regulation of apoptotic process • Wnt signaling pathway • positive regulation of translation • protein localization to cytoplasmic stress granule • transcription, DNA-templated • cellular response to osmotic stress • positive regulation of G1/S transition of mitotic cell cycle • intrinsic apoptotic signaling pathway • positive regulation of cysteine-type endopeptidase activity involved in apoptotic process • positive regulation of cell growth • GO:1901313 positive regulation of gene expression • mature ribosome assembly • cellular response to arsenic-containing substance • negative regulation of cell growth • positive regulation of chemokine (C-C motif) ligand 5 production • RNA secondary structure unwinding • positive regulation of apoptotic process • positive regulation of viral genome replication • GO:0022415 viral process • innate immune response • positive regulation of translational initiation • regulation of translation • extrinsic apoptotic signaling pathway via death domain receptors • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • positive regulation of interferon-beta production • DNA duplex unwinding • neutrophil degranulation • positive regulation of protein serine/threonine kinase activity • positive regulation of canonical Wnt signaling pathway • translational initiation Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	1654	n/a
Ensembl	ENSG00000215301	n/a
UniProt	O00571	n/a
RefSeq (mRNA)	NM_001193416 NM_001193417 NM_001356 NM_024005 NM_001363819	n/a
RefSeq (protein)	NP_001180345 NP_001180346 NP_001347 NP_001350748	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn DDX3X yw DDX3X a elwir hefyd yn ATP-dependent RNA helicase DDX3X (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom X dynol, band Xp11.4.^[2]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn DDX3X.

• "Rottlerin upregulates DDX3 expression in hepatocellular carcinoma. ". Biochem Biophys Res Commun. 2018. PMID 29203243.
• "DDX3X mutations in two girls with a phenotype overlapping Toriello-Carey syndrome. ". Am J Med Genet A. 2017. PMID 28371085.
• "Lessons learned from additional research analyses of unsolved clinical exome cases. ". Genome Med. 2017. PMID 28327206.
• "The ATP-Dependent RNA Helicase DDX3X Modulates Herpes Simplex Virus 1 Gene Expression. ". J Virol. 2017. PMID 28148788.
• "The prognostic effect of DDX3 upregulation in distant breast cancer metastases.". Clin Exp Metastasis. 2017. PMID 27999982.