CLIP1

CLIP1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2CP5, 2CP6, 2E3H, 2E3I, 2E4H, 2HQH, 2QK0, 3E2U, 3RDV
Dynodwyr
Cyfenwau	CLIP1, CLIP, CLIP-170, CLIP170, CYLN1, RSN, CAP-Gly domain containing linker protein 1
Dynodwyr allanol	OMIM: 179838 HomoloGene: 74455 GeneCards: CLIP1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • protein homodimerization activity • microtubule binding • microtubule plus-end binding • metal ion binding • tubulin binding • GO:0001948, GO:0016582 protein binding • zinc ion binding • identical protein binding Cydrannau o'r gell • cytosol • endosome • centrosome • cell projection • bilen • microtubule cytoskeleton • ruffle • microtubule plus-end • macropinosome • cytoplasmic microtubule • microtubule • Cytosgerbwd • intermediate filament • cytoplasmic vesicle membrane • GO:0016023 cytoplasmic vesicle • kinetochore • nuclear envelope • cytoplasm Prosesau biolegol • microtubule bundle formation • positive regulation of microtubule polymerization • protein transport into plasma membrane raft • GO:0007067 Mitosis Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	6249	n/a
Ensembl	ENSG00000130779	n/a
UniProt	P30622	n/a
RefSeq (mRNA)	NM_001247997 NM_002956 NM_198240 NM_001389291	n/a
RefSeq (protein)	NP_001234926 NP_002947 NP_937883	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn CLIP1 yw CLIP1 a elwir hefyd yn CAP-Gly domain containing linker protein 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 12, band 12q24.31.^[2]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CLIP1.

• "A defect in the CLIP1 gene (CLIP-170) can cause autosomal recessive intellectual disability. ". Eur J Hum Genet. 2015. PMID 24569606.
• "Regulation of tumor angiogenesis by the microtubule-binding protein CLIP-170. ". Protein Cell. 2013. PMID 23549612.
• "Accelerated actin filament polymerization from microtubule plus ends. ". Science. 2016. PMID 27199431.
• "Microtubule plus end-associated CLIP-170 initiates HSV-1 retrograde transport in primary human cells. ". J Cell Biol. 2015. PMID 26504169.
• "CLIP-170 tethers kinetochores to microtubule plus ends against poleward force by dynein for stable kinetochore-microtubule attachment.". FEBS Lett. 2015. PMID 26231764.