CDKN1B

CDKN1B
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2AST, 1H27, 1JSU
Dynodwyr
Cyfenwau	CDKN1B, CDKN4, KIP1, MEN1B, MEN4, P27KIP1, cyclin-dependent kinase inhibitor 1B, cyclin dependent kinase inhibitor 1B
Dynodwyr allanol	OMIM: 600778 HomoloGene: 2999 GeneCards: CDKN1B
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0001948, GO:0016582 protein binding • protein phosphatase binding • cyclin-dependent protein serine/threonine kinase activity • protein kinase inhibitor activity • protein kinase binding • cyclin binding • cyclin-dependent protein serine/threonine kinase inhibitor activity • Hsp70 protein binding • GO:0032403 protein-containing complex binding • chaperone binding Cydrannau o'r gell • cytoplasm • cytosol • endosome • nucleoplasm • Cul4A-RING E3 ubiquitin ligase complex • cnewyllyn cell • intracellular membrane-bounded organelle • GO:0009327 protein-containing complex Prosesau biolegol • Notch signaling pathway • regulation of cyclin-dependent protein serine/threonine kinase activity • DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest • response to estradiol • positive regulation of cell death • response to hypoxia • response to amino acid • response to cadmium ion • GO:1903364 positive regulation of protein catabolic process • GO:1904578 response to organic cyclic compound • cellular response to lithium ion • GO:1904579 cellular response to organic cyclic compound • response to peptide hormone • marwolaeth celloedd • negative regulation of apoptotic process • clyw • response to glucose • potassium ion transport • regulation of cell population proliferation • negative regulation of cell growth • negative regulation of epithelial cell proliferation involved in prostate gland development • positive regulation of cell population proliferation • positive regulation of cyclin-dependent protein serine/threonine kinase activity • negative regulation of epithelial cell proliferation • positive regulation of microtubule polymerization • inner ear development • GO:1904577 cellular response to antibiotic • cell cycle • negative regulation of phosphorylation • GO:0045996 negative regulation of transcription, DNA-templated • autophagic cell death • negative regulation of cell population proliferation • negative regulation of mitotic cell cycle • negative regulation of kinase activity • positive regulation of cell cycle • negative regulation of vascular associated smooth muscle cell proliferation • placenta development • regulation of exit from mitosis • regulation of lens fiber cell differentiation • negative regulation of cyclin-dependent protein kinase activity • negative regulation of cell cycle • negative regulation of cyclin-dependent protein serine/threonine kinase activity • G1/S transition of mitotic cell cycle Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	1027	n/a
Ensembl	ENSG00000111276	n/a
UniProt	P46527	n/a
RefSeq (mRNA)	NM_004064	n/a
RefSeq (protein)	NP_004055	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn CDKN1B yw CDKN1B a elwir hefyd yn Cyclin dependent kinase inhibitor 1B (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 12, band 12p13.1.^[2]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CDKN1B.

• "p27 Is a Candidate Prognostic Biomarker and Metastatic Promoter in Osteosarcoma. ". Cancer Res. 2016. PMID 27197201.
• "Cryptic sequence features within the disordered protein p27Kip1 regulate cell cycle signaling. ". Proc Natl Acad Sci U S A. 2016. PMID 27140628.
• "Cyclins A, B, E and p27 in Endometrial Endometrioid Adenocarcinoma. ". Anticancer Res. 2016. PMID 27919969.
• "P27/CDKN1B Translational Regulators in Pituitary Tumorigenesis. ". Horm Metab Res. 2016. PMID 27824399.
• "Rewiring of the apoptotic TGF-β-SMAD/NFκB pathway through an oncogenic function of p27 in human papillary thyroid cancer.". Oncogene. 2017. PMID 27452523.