CD38

CD38
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 4TMF, 1YH3, 1ZVM, 2EF1, 2HCT, 2I65, 2I66, 2I67, 2O3Q, 2O3R, 2O3S, 2O3T, 2O3U, 2PGJ, 2PGL, 3DZF, 3DZG, 3DZH, 3DZI, 3DZJ, 3DZK, 3F6Y, 3I9M, 3I9N, 3OFS, 3RAJ, 3ROK, 3ROM, 3ROP, 3ROQ, 3U4H, 3U4I, 4CMH, 4F45, 4F46, 4OGW, 4XJS, 4XJT, 5F1K, 5F1O, 5F21
Dynodwyr
Cyfenwau	CD38, ADPRC1, ADPRC 1, CD38 molecule
Dynodwyr allanol	OMIM: 107270 HomoloGene: 1345 GeneCards: CD38
EC number	2.4.99.20
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • transferase activity • hydrolase activity, acting on glycosyl bonds • NAD(P)+ nucleosidase activity • hydrolase activity • NAD+ nucleotidase, cyclic ADP-ribose generating • NAD+ nucleosidase activity • phosphorus-oxygen lyase activity • identical protein binding Cydrannau o'r gell • integral component of membrane • bilen • intracellular membrane-bounded organelle • cell surface • extracellular exosome • cnewyllyn cell • Cellbilen • basolateral plasma membrane • secretory granule membrane Prosesau biolegol • B cell receptor signaling pathway • response to cytokine • response to estradiol • response to interleukin-1 • response to hypoxia • response to retinoic acid • positive regulation of cytosolic calcium ion concentration • response to progesterone • female pregnancy • negative regulation of apoptotic process • response to hydroperoxide • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • positive regulation of cell growth • positive regulation of B cell proliferation • positive regulation of vasoconstriction • long-term depression • apoptotic signaling pathway • response to hormone • GO:0045996 negative regulation of transcription, DNA-templated • GO:0072468 signal transduction • positive regulation of insulin secretion • negative regulation of bone resorption • NAD metabolic process • positive regulation of cell population proliferation • negative regulation of neuron projection development • artery smooth muscle contraction Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	952	n/a
Ensembl	ENSG00000004468	n/a
UniProt	P28907	n/a
RefSeq (mRNA)	NM_001775	n/a
RefSeq (protein)	NP_001766	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn CD38 yw CD38 a elwir hefyd yn CD38 molecule (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 4, band 4p15.32.^[2]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CD38.

• ADPRC1
• ADPRC*1

• "CD38 enhances the proliferation and inhibits the apoptosis of cervical cancer cells by affecting the mitochondria functions. ". Mol Carcinog. 2017. PMID 28544069.
• "ADP ribosyl-cyclases (CD38/CD157), social skills and friendship. ". Psychoneuroendocrinology. 2017. PMID 28212520.
• "Low CD38 Identifies Progenitor-like Inflammation-Associated Luminal Cells that Can Initiate Human Prostate Cancer and Predict Poor Outcome. ". Cell Rep. 2016. PMID 27926864.
• "CD38 expression and complement inhibitors affect response and resistance to daratumumab therapy in myeloma. ". Blood. 2016. PMID 27307294.
• "CD38 Expression in a Subset of Memory T Cells Is Independent of Cell Cycling as a Correlate of HIV Disease Progression.". Dis Markers. 2016. PMID 27064238.