CD28

CD28
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1YJD, 3WA4, 5AUL
Dynodwyr
Cyfenwau	CD28, Tp44, CD28 molecule
Dynodwyr allanol	OMIM: 186760 HomoloGene: 4473 GeneCards: CD28
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • coreceptor activity • protease binding • GO:0001948, GO:0016582 protein binding • identical protein binding • protein kinase binding • phosphatidylinositol-4,5-bisphosphate 3-kinase activity Cydrannau o'r gell • integral component of membrane • cytosol • bilen • Cellbilen • integral component of plasma membrane • immunological synapse • external side of plasma membrane • cell surface • protein complex involved in cell adhesion Prosesau biolegol • regulatory T cell differentiation • regulation of regulatory T cell differentiation • T cell costimulation • GO:0019049, GO:0030683 mitigation of host defenses by virus • positive regulation of translation • negative regulation of gene expression • negative thymic T cell selection • cell surface receptor signaling pathway • GO:1901313 positive regulation of gene expression • humoral immune response • positive regulation of T cell proliferation • positive regulation of alpha-beta T cell proliferation • GO:0046730, GO:0046737, GO:0046738, GO:0046736 immune response • apoptotic signaling pathway • positive regulation of phosphatidylinositol 3-kinase signaling • positive regulation of isotype switching to IgG isotypes • positive regulation of viral genome replication • T cell receptor signaling pathway • positive regulation of mitotic nuclear division • positive regulation of inflammatory response to antigenic stimulus • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • positive regulation of interleukin-10 production • phosphatidylinositol phosphate biosynthetic process • positive regulation of interleukin-4 production • positive regulation of protein kinase B signaling • T cell activation • negative regulation of apoptotic process • regulation of T cell proliferation • immune system process Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	940	n/a
Ensembl	ENSG00000178562	n/a
UniProt	P10747	n/a
RefSeq (mRNA)	NM_001243077 NM_001243078 NM_006139	n/a
RefSeq (protein)	NP_001230006 NP_001230007 NP_006130	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn CD28 yw CD28 a elwir hefyd yn CD28 molecule (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 2, band 2q33.2.^[2]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CD28.

• Tp44

• "Human mast cells costimulate T cells through a CD28-independent interaction. ". Eur J Immunol. 2016. PMID 26860071.
• "Recurrent activating mutations of CD28 in peripheral T-cell lymphomas. ". Leukemia. 2016. PMID 26719098.
• "Functional analysis of acquired CD28 mutations identified in cutaneous T cell lymphoma. ". Cell Immunol. 2017. PMID 28711152.
• "CD28 family of receptors on T cells in chronic HBV infection: Expression characteristics, clinical significance and correlations with PD-1 blockade. ". Mol Med Rep. 2016. PMID 27314219.
• "Loss of CD28 on Peripheral T Cells Decreases the Risk for Early Acute Rejection after Kidney Transplantation.". PLoS One. 2016. PMID 26950734.