BID

BID
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1ZY3, 2BID, 2KBW, 2M5B, 2M5I, 4BD2, 4ZEQ, 5AJJ, 4QVE, 4ZIG, 4ZII, 5C3F
Dynodwyr
Cyfenwau	BID, Bid, 2700049M22Rik, AI875481, AU022477, FP497, BH3 interacting domain death agonist
Dynodwyr allanol	OMIM: 601997 HomoloGene: 923 GeneCards: BID
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • death receptor binding • GO:0001948, GO:0016582 protein binding • ubiquitin protein ligase binding • protein heterodimerization activity Cydrannau o'r gell • cytoplasm • bilen • mitochondrial membranes • mitochondrial outer membrane • mitocondria • integral component of mitochondrial membrane • cytosol Prosesau biolegol • neuron apoptotic process • positive regulation of protein homooligomerization • positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway • extrinsic apoptotic signaling pathway • signal transduction in response to DNA damage • regulation of protein oligomerization • establishment of protein localization to membrane • protein targeting to mitochondrion • regulation of mitochondrial membrane permeability involved in apoptotic process • regulation of G1/S transition of mitotic cell cycle • positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway • regulation of cell population proliferation • apoptotic mitochondrial changes • positive regulation of protein oligomerization • positive regulation of apoptotic process • positive regulation of release of cytochrome c from mitochondria • positive regulation of extrinsic apoptotic signaling pathway • protein homooligomerization • activation of cysteine-type endopeptidase activity involved in apoptotic process • mitochondrial outer membrane permeabilization • extrinsic apoptotic signaling pathway via death domain receptors • hepatocyte apoptotic process • release of cytochrome c from mitochondria • GO:0097285 apoptotic process • regulation of apoptotic process • positive regulation of mitochondrial membrane potential • mitochondrial ATP synthesis coupled electron transport • negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage • positive regulation of fibroblast apoptotic process • positive regulation of apoptotic signaling pathway • negative regulation of apoptotic process • positive regulation of intrinsic apoptotic signaling pathway Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	637	n/a
Ensembl	ENSG00000015475	n/a
UniProt	P55957	n/a
RefSeq (mRNA)	NM_001196 NM_001244567 NM_001244569 NM_001244570 NM_001244572 NM_197966 NM_197967	n/a
RefSeq (protein)	NP_001187 NP_001231496 NP_001231498 NP_001231499 NP_001231501 NP_932070 NP_932071 NP_001187.1 NP_001231496.1	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn BID yw BID a elwir hefyd yn BH3 interacting domain death agonist, isoform CRA_d a BH3 interacting domain death agonist (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 22, band 22q11.21.^[2]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn BID.

• FP497

• "Cleavage by Caspase 8 and Mitochondrial Membrane Association Activate the BH3-only Protein Bid during TRAIL-induced Apoptosis. ". J Biol Chem. 2016. PMID 27053107.
• "Human islet cells are killed by BID-independent mechanisms in response to FAS ligand. ". Apoptosis. 2016. PMID 26758067.
• "Adenovirus-mediated truncated Bid overexpression induced by the Cre/LoxP system promotes the cell apoptosis of CD133+ ovarian cancer stem cells. ". Oncol Rep. 2017. PMID 27878291.
• "Bcl-2 proteins bid and bax form a network to permeabilize the mitochondria at the onset of apoptosis. ". Cell Death Dis. 2016. PMID 27763642.
• "A novel combinatorial strategy using Seliciclib(®) and Belinostat(®) for eradication of non-small cell lung cancer via apoptosis induction and BID activation.". Cancer Lett. 2016. PMID 27461583.