ATOX1

ATOX1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1FE0, 1FE4, 1FEE, 1TL4, 1TL5, 2K1R, 2LQ9, 3CJK, 3IWL, 3IWX, 4QOT, 4YDX, 4YEA
Dynodwyr
Cyfenwau	ATOX1, ATX1, HAH1, antioxidant 1 copper chaperone
Dynodwyr allanol	OMIM: 602270 HomoloGene: 2984 GeneCards: ATOX1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • copper ion transmembrane transporter activity • metallochaperone activity • copper ion binding • GO:0001948, GO:0016582 protein binding • copper chaperone activity • copper-dependent protein binding • metal ion binding • ATPase binding Cydrannau o'r gell • cytosol Prosesau biolegol • GO:0070839 metal ion transport • copper ion transport • cludo ïon • protein maturation by copper ion transfer • copper ion transmembrane transport • cellular copper ion homeostasis • GO:0001306 response to oxidative stress • negative regulation of apoptotic process • copper ion export Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	475	n/a
Ensembl	ENSG00000177556	n/a
UniProt	O00244	n/a
RefSeq (mRNA)	NM_004045	n/a
RefSeq (protein)	NP_004036	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn ATOX1 yw ATOX1 a elwir hefyd yn Antioxidant 1 copper chaperone (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 5, band 5q33.1.^[2]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn ATOX1.

• ATX1
• HAH1

• "Binding of Copper and Cisplatin to Atox1 Is Mediated by Glutathione through the Formation of Metal-Sulfur Clusters. ". Biochemistry. 2017. PMID 28549213.
• "The structural flexibility of the human copper chaperone Atox1: Insights from combined pulsed EPR studies and computations. ". Protein Sci. 2017. PMID 28543811.
• "Thiol-based copper handling by the copper chaperone Atox1. ". IUBMB Life. 2017. PMID 28294521.
• "Copper chaperone Atox1 plays role in breast cancer cell migration. ". Biochem Biophys Res Commun. 2017. PMID 28027931.
• "ATOX1 gene silencing increases susceptibility to anticancer therapy based on copper ionophores or chelating drugs.". J Inorg Biochem. 2016. PMID 26784148.