File:DNA gyrase and topoisomerase IV identification in 4-pyridone group.pdf

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The identification of a bioactive molecule with the target of DNA gyrase and topoisomerase IV inhibition by the minimum structure in 4-pyridone group.

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Description
English: Molecule 1 contains five aromatic rings fused to the core (4-pyridone), molecule 2 contains one methyl at X8, molecule 4 doesn’t contain -COO or isothiazol-3(2H)-one fused to the core at X3, molecule 5 contains hydrogen at X1 and molecule 6 contains one methyl attached to the aromatic ring (phenyl) at X8 (here X8 means six-membered aromatic ring fused to the core at X5) in position 6. Therefore, the target of molecules 1, 2, 4, 5 and 6 is not DNA gyrase and topoisomerase IV inhibition.


Reference: Forouzesh, Abed; Samadi Foroushani, Sadegh; Forouzesh, Fatemeh; Zand, Eskandar (2019). "Reliable target prediction of bioactive molecules based on chemical similarity without employing statistical methods". Frontiers in Pharmacology. 10: 835. doi:10.3389/fphar.2019.00835
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Author SSamadi15

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Date/TimeThumbnailDimensionsUserComment
current17:22, 28 August 2019Thumbnail for version as of 17:22, 28 August 20191,275 × 1,650 (237 KB)SSamadi15 (talk | contribs)Reverted to version as of 18:29, 27 August 2019 (UTC)
17:14, 28 August 2019Thumbnail for version as of 17:14, 28 August 20191,275 × 1,650 (340 KB)SSamadi15 (talk | contribs)Molecule 1 contains five aromatic rings fused to the core (4-pyridone), molecule 2 contains one methyl at X8, molecule 4 doesn’t contain -COO or isothiazol-3(2H)-one fused to the core at X3, molecule 5 contains hydrogen at X1 and molecule 6 contains one methyl attached to the aromatic ring (phenyl) at X8 (here X8 means six-membered aromatic ring fused to the core at X5) in position 6. Therefore, the target of molecules 1, 2, 4, 5 and 6 is not DNA gyrase and topoisomerase IV inhibition. Refe...
16:58, 28 August 2019Thumbnail for version as of 16:58, 28 August 20191,275 × 1,650 (265 KB)SSamadi15 (talk | contribs)Molecule 1 contains five aromatic rings fused to the core (4-pyridone), molecule 2 contains one methyl at X<sub>8</sub>, molecule 4 doesn’t contain -COO or isothiazol-3(2''H'')-one fused to the core at X<sub>3</sub>, molecule 5 contains hydrogen at X<sub>1</sub> and molecule 6 contains one methyl attached to the aromatic ring (phenyl) at X<sub>8</sub> (here X<sub>8</sub> means six-membered aromatic ring fused to the core at X<sub>5</sub>) in position 6. Therefore, the target of molecules 1, 2...
18:29, 27 August 2019Thumbnail for version as of 18:29, 27 August 20191,275 × 1,650 (237 KB)SSamadi15 (talk | contribs)User created page with UploadWizard

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