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TSC22D1

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TSC22D1
Identifikatori
AliasiTSC22D1
Vanjski ID-jeviOMIM: 607715 MGI: 109127 HomoloGene: 7573 GeneCards: TSC22D1
Lokacija gena (čovjek)
Hromosom 13 (čovjek)
Hrom.Hromosom 13 (čovjek)[1]
Hromosom 13 (čovjek)
Genomska lokacija za TSC22D1
Genomska lokacija za TSC22D1
Bend13q14.11Početak44,432,143 bp[1]
Kraj44,577,147 bp[1]
Lokacija gena (miš)
Hromosom 14 (miš)
Hrom.Hromosom 14 (miš)[2]
Hromosom 14 (miš)
Genomska lokacija za TSC22D1
Genomska lokacija za TSC22D1
Bend14 D3|14 40.44 cMPočetak76,652,401 bp[2]
Kraj76,745,205 bp[2]
Obrazac RNK ekspresije
Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija GO:0001948, GO:0016582 vezivanje za proteine
GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity
GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific
Ćelijska komponenta citoplazma
jedro
Biološki proces GO:0009373 regulation of transcription, DNA-templated
transcription by RNA polymerase II
transcription, DNA-templated
GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II
Izvori:Amigo / QuickGO
Ortolozi
VrsteČovjekMiš
Entrez
Ensembl
UniProt
RefSeq (mRNK)

NM_001243797
NM_001243798
NM_001243799
NM_006022
NM_183422

NM_001177751
NM_009366
NM_207652
NM_001310646
NM_001310647

RefSeq (bjelančevina)

NP_001230726
NP_001230727
NP_001230728
NP_006013
NP_904358

NP_001171222
NP_001297575
NP_001297576
NP_033392
NP_997535

Lokacija (UCSC)Chr 13: 44.43 – 44.58 MbChr 14: 76.65 – 76.75 Mb
PubMed pretraga[3][4]
Wikipodaci
Pogledaj/uredi – čovjekPogledaj/uredi – miš

Domenski protein 1 porodice TSC22 je protein koji je kod ljudi kodiran genom TSC22D1.[5][6]

TSC22 kodira transkripcijski faktor i pripada velikoj porodici gena ranog odgovora.[7]

TSC22D1 tvori homodimere preko svog konzerviranog domena leucinskog zatvarača i heterodimerizira s TSC22D4. TSC22D1 ima transkripcijsku represornu aktivnost.[8]

Aminokiselinska sekvenca

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Dužina polipeptidnog lanca je 1.073 aminokiseline, a molekulska težina 109.677 Da.[9].

1020304050
MHQPPESTAAAAAAADISARKMAHPAMFPRRGSGSGSASALNAAGTGVGS
NATSSEDFPPPSLLQPPPPAASSTSGPQPPPPQSLNLLSQAQLQAQPLAP
GGTQMKKKSGFQITSVTPAQISASISSNNSIAEDTESYDDLDESHTEDLS
SSEILDVSLSRATDLGEPERSSSEETLNNFQEAETPGAVSPNQPHLPQPH
LPHLPQQNVVINGNAHPHHLHHHHQIHHGHHLQHGHHHPSHVAVASASIT
GGPPSSPVSRKLSTTGSSDSITPVAPTSAVSSSGSPASVMTNMRAPSTTG
GIGINSVTGTSTVNNVNITAVGSFNPNVTSSMLGNVNISTSNIPSAAGVS
VGPGVTSGVNVNILSGMGNGTISSSAAVSSVPNAAAGMTGGSVSSQQQQP
TVNTSRFRVVKLDSSSEPFKKGRWTCTEFYEKENAVPATEGVLINKVVET
VKQNPIEVTSERESTSGSSVSSSVSTLSHYTESVGSGEMGAPTVVVQQQQ
QQQQQQQQQPALQGVTLQQMDFGSTGPQSIPAVSIPQSISQSQISQVQLQ
SQELSYQQKQGLQPVPLQATMSAATGIQPSPVNVVGVTSALGQQPSISSL
AQPQLPYSQAAPPVQTPLPGAPPPQQLQYGQQQPMVSTQMAPGHVKSVTQ
NPASEYVQQQPILQTAMSSGQPSSAGVGAGTTVIPVAQPQGIQLPVQPTA
VPAQPAGASVQPVGQAPAAVSAVPTGSQIANIGQQANIPTAVQQPSTQVP
PSVIQQGAPPSSQVVPPAQTGIIHQGVQTSAPSLPQQLVIASQSSLLTVP
PQPQGVEPVAQGIVSQQLPAVSSLPSASSISVTSQVSSTGPSGMPSAPTN
LVPPQNIAQTPATQNGNLVQSVSQPPLIATNTNLPLAQQIPLSSTQFSAQ
SLAQAIGSQIEDARRAAEPSLVGLPQTISGDSGGMSAVSDGSSSSLAASA
SLFPLKVLPLTTPLVDGEDESSSGASVVAIDNKIEQAMDLVKSHLMYAVR
EEVEVLKEQIKELIEKNSQLEQENNLLKTLASPEQLAQFQAQLQTGSPPA
TTQPQGTTQPPAQPASQGSGPTA
Simboli

Reference

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000102804 - Ensembl, maj 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022010 - Ensembl, maj 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Jay P, Ji JW, Marsollier C, Taviaux S, Berge-Lefranc JL, Berta P (Jul 1996). "Cloning of the human homologue of the TGF beta-stimulated clone 22 gene". Biochem Biophys Res Commun. 222 (3): 821–6. doi:10.1006/bbrc.1996.0825. PMID 8651929.
  6. ^ Ohta S, Shimekake Y, Nagata K (Mar 1997). "Molecular cloning and characterization of a transcription factor for the C-type natriuretic peptide gene promoter". Eur J Biochem. 242 (3): 460–6. doi:10.1111/j.1432-1033.1996.460rr.x. PMID 9022669.
  7. ^ "Entrez Gene: TSC22D1 TSC22 domain family, member 1".
  8. ^ Kester HA, Blanchetot C, den Hertog J, van der Saag PT, van der Burg B (septembar 1999). "Transforming growth factor-beta-stimulated clone-22 is a member of a family of leucine zipper proteins that can homo- and heterodimerize and has transcriptional repressor activity". J. Biol. Chem. 274 (39): 27439–47. doi:10.1074/jbc.274.39.27439. PMID 10488076.
  9. ^ "UniProt, Q15714". Pristupljeno 5. 8. 2021.

Dopunska literatura

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Vanjski linkovi

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