TACSTD2

TACSTD2
Dostupne strukture
PDB	Pretraga ortologa: PDBe RCSB
Spisak PDB ID kodova
	2MAE, 2MVK, 2MVL
Identifikatori
Aliasi	TACSTD2
Vanjski ID-jevi	OMIM: 137290 MGI: 1861606 HomoloGene: 1763 GeneCards: TACSTD2
Lokacija gena (čovjek)
Hrom.	Hromosom 1 (čovjek)
Kraj	58,577,252 bp
Lokacija gena (miš)
Hrom.	Hromosom 6 (miš)
Kraj	67,512,780 bp
Obrazac RNK ekspresije
	; ;
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• GO:0001948, GO:0016582 vezivanje za proteine; • signaling receptor activity; • cadherin binding involved in cell-cell adhesion;
Ćelijska komponenta	• integral component of membrane; • citosol; • lateral plasma membrane; • membrana; • ćelijska membrana; • integral component of plasma membrane; • basal plasma membrane; • Egzosom; • jedro; • Vanćelijsko; • bicellular tight junction;
Biološki proces	• ureteric bud morphogenesis; • response to stimulus; • negative regulation of ruffle assembly; • negative regulation of cell motility; • cell surface receptor signaling pathway; • negative regulation of branching involved in ureteric bud morphogenesis; • Ćelijska proliferacija; • regulation of epithelial cell proliferation; • negative regulation of stress fiber assembly; • negative regulation of substrate adhesion-dependent cell spreading; • negative regulation of epithelial cell migration; • Vid; • cell-cell adhesion; • positive regulation of stem cell differentiation;
	Izvori:Amigo / QuickGO
Ortolozi
	4070
	56753
	ENSG00000184292
	ENSMUSG00000051397
	P09758
	Q8BGV3
	NM_002353
	NM_020047
	NP_002344
	NP_064431
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Tumor-pridruženi kalcijski signalni transduktor 2, znan i kao Trop-2 i epitelni glikoprotein-1, antigen (EGP-1),^[5] jest protein koji je kod ljudi kodiran genom TACSTD2 sa hromosoma 1.^[6]^[7]^[8]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 323 aminokiselina, a molekulska težina 35.709 Da.^[9]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MARGPGLAPP	PLRLPLLLLV	LAAVTGHTAA	QDNCTCPTNK	MTVCSPDGPG
GRCQCRALGS	GMAVDCSTLT	SKCLLLKARM	SAPKNARTLV	RPSEHALVDN
DGLYDPDCDP	EGRFKARQCN	QTSVCWCVNS	VGVRRTDKGD	LSLRCDELVR
THHILIDLRH	RPTAGAFNHS	DLDAELRRLF	RERYRLHPKF	VAAVHYEQPT
IQIELRQNTS	QKAAGDVDIG	DAAYYFERDI	KGESLFQGRG	GLDLRVRGEP
LQVERTLIYY	LDEIPPKFSM	KRLTAGLIAV	IVVVVVALVA	GMAVLVITNR
RKSGKYKKVE	IKELGELRKE	PSL

Funkcija

Ovaj gen bez introna kodira antigen povezan sa karcinomom, definisan monoklonskim antitijeom GA733. Ovaj antigen je član porodice koja uključuje najmanje dva tipa I mrmbranskih proteina. Transdukuje unutarćelijski kalcijski signal i deluje kao površinski ćelijski receptor.

Mutacije ovog gena dovode do želatinozne distrofije rožnjače, autosomno recesivnog poremećaja koji karakterizira teška amiloidoza koja dovodi do sljepoće.^[8]

Ovaj antigen je meta sacituzumab-govitecana, konjugata antitijelo-lijek.

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000184292 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000051397 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Immunomedics Awarded Fast Track Designation by FDA for Sacituzumab Govitecan (IMMU-132) for Triple-Negative Breast Cancer Therapy [1]
^ Linnenbach AJ, Seng BA, Wu S, Robbins S, Scollon M, Pyrc JJ, Druck T, Huebner K (Apr 1993). "Retroposition in a family of carcinoma-associated antigen genes". Mol Cell Biol. 13 (3): 1507–15. doi:10.1128/MCB.13.3.1507. PMC 359462. PMID 8382772.
^ Calabrese G, Crescenzi C, Morizio E, Palka G, Guerra E, Alberti S (Apr 2001). "Assignment of TACSTD1 (alias TROP1, M4S1) to human chromosome 2p21 and refinement of mapping of TACSTD2 (alias TROP2, M1S1) to human chromosome 1p32 by in situ hybridization". Cytogenet Cell Genet. 92 (1–2): 164–5. doi:10.1159/000056891. PMID 11306819. S2CID 9708614.
^ ^a ^b "Entrez Gene: TACSTD2 tumor-associated calcium signal transducer 2".
^ "UniProt, P09758" (jezik: engleski). Pristupljeno 5. 12. 2021.

Dopunska literatura

Linnenbach AJ, Wojcierowski J, Wu SA, et al. (1989). "Sequence investigation of the major gastrointestinal tumor-associated antigen gene family, GA733". Proc. Natl. Acad. Sci. U.S.A. 86 (1): 27–31. Bibcode:1989PNAS...86...27L. doi:10.1073/pnas.86.1.27. PMC 286396. PMID 2911574.
Fornaro M, Dell'Arciprete R, Stella M, et al. (1995). "Cloning of the gene encoding Trop-2, a cell-surface glycoprotein expressed by human carcinomas". Int. J. Cancer. 62 (5): 610–8. doi:10.1002/ijc.2910620520. PMID 7665234. S2CID 23260113.
El Sewedy T, Fornaro M, Alberti S (1998). "Cloning of the murine TROP2 gene: conservation of a PIP2-binding sequence in the cytoplasmic domain of TROP-2". Int. J. Cancer. 75 (2): 324–30. doi:10.1002/(SICI)1097-0215(19980119)75:2<324::AID-IJC24>3.0.CO;2-B. PMID 9462726.
Ripani E, Sacchetti A, Corda D, Alberti S (1998). "Human Trop-2 is a tumor-associated calcium signal transducer". Int. J. Cancer. 76 (5): 671–6. doi:10.1002/(SICI)1097-0215(19980529)76:5<671::AID-IJC10>3.0.CO;2-7. PMID 9610724.
Tsujikawa M, Kurahashi H, Tanaka T, et al. (1999). "Identification of the gene responsible for gelatinous drop-like corneal dystrophy". Nat. Genet. 21 (4): 420–3. doi:10.1038/7759. PMID 10192395. S2CID 2275476.
Nakamura T, Nishida K, Dota A, et al. (2000). "Gelatino-lattice corneal dystrophy: clinical features and mutational analysis". Am. J. Ophthalmol. 129 (5): 665–6. doi:10.1016/S0002-9394(00)00369-X. PMID 10844062.
Kinoshita S, Nishida K, Dota A, Abbie F, et al. (2000). "Epithelial barrier function and ultrastructure of gelatinous drop-like corneal dystrophy". Cornea. 19 (4): 551–5. doi:10.1097/00003226-200007000-00029. PMID 10928776. S2CID 43011710.
Tsujikawa M, Tsujikawa K, Maeda N, et al. (2000). "Rapid detection of M1S1 mutations by the protein truncation test". Invest. Ophthalmol. Vis. Sci. 41 (9): 2466–8. PMID 10937555.
Ha NT, Fujiki K, Hotta Y, et al. (2000). "Q118X mutation of M1S1 gene caused gelatinous drop-like corneal dystrophy: the P501T of BIGH3 gene found in a family with gelatinous drop-like corneal dystrophy". Am. J. Ophthalmol. 130 (1): 119–20. doi:10.1016/S0002-9394(00)00596-1. PMID 11004271.
Tasa G, Kals J, Muru K, et al. (2001). "A novel mutation in the M1S1 gene responsible for gelatinous droplike corneal dystrophy". Invest. Ophthalmol. Vis. Sci. 42 (12): 2762–4. PMID 11687514.
Yoshida S, Kumano Y, Yoshida A, et al. (2002). "Two brothers with gelatinous drop-like dystrophy at different stages of the disease: role of mutational analysis". Am. J. Ophthalmol. 133 (6): 830–2. doi:10.1016/S0002-9394(02)01407-1. PMID 12036680.
Ren Z, Lin PY, Klintworth GK, et al. (2002). "Allelic and locus heterogeneity in autosomal recessive gelatinous drop-like corneal dystrophy". Hum. Genet. 110 (6): 568–77. doi:10.1007/s00439-002-0729-z. PMID 12107443. S2CID 24052349.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ha NT, Chau HM, Cung le X, et al. (2003). "A novel mutation of M1S1 gene found in a Vietnamese patient with gelatinous droplike corneal dystrophy". Am. J. Ophthalmol. 135 (3): 390–3. doi:10.1016/S0002-9394(02)01952-9. PMID 12614764.
Gires O, Eskofier S, Lang S, et al. (2003). "Cloning and characterisation of a 1.1 kb fragment of the carcinoma-associated epithelial cell adhesion molecule promoter". Anticancer Res. 23 (4): 3255–61. PMID 12926061.
Tian X, Fujiki K, Li Q, et al. (2004). "Compound heterozygous mutations of M1S1 gene in gelatinous droplike corneal dystrophy". Am. J. Ophthalmol. 137 (3): 567–9. doi:10.1016/j.ajo.2003.08.008. PMID 15013888.
Murakami A, Kimura S, Fujiki K, et al. (2004). "Mutations in the membrane component, chromosome 1, surface marker 1 (M1S1) gene in gelatinous drop-like corneal dystrophy". Jpn. J. Ophthalmol. 48 (4): 317–20. doi:10.1007/s10384-003-0064-5. PMID 15295654. S2CID 28358081.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000184292 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000051397 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Immunomedics Awarded Fast Track Designation by FDA for Sacituzumab Govitecan (IMMU-132) for Triple-Negative Breast Cancer Therapy [1]

[pmid8382772-6] Linnenbach AJ, Seng BA, Wu S, Robbins S, Scollon M, Pyrc JJ, Druck T, Huebner K (Apr 1993). "Retroposition in a family of carcinoma-associated antigen genes". Mol Cell Biol. 13 (3): 1507–15. doi:10.1128/MCB.13.3.1507. PMC 359462. PMID 8382772.

[pmid11306819-7] Calabrese G, Crescenzi C, Morizio E, Palka G, Guerra E, Alberti S (Apr 2001). "Assignment of TACSTD1 (alias TROP1, M4S1) to human chromosome 2p21 and refinement of mapping of TACSTD2 (alias TROP2, M1S1) to human chromosome 1p32 by in situ hybridization". Cytogenet Cell Genet. 92 (1–2): 164–5. doi:10.1159/000056891. PMID 11306819. S2CID 9708614.

[entrez-8] "Entrez Gene: TACSTD2 tumor-associated calcium signal transducer 2".

[UniProt-9] "UniProt, P09758" (jezik: engleski). Pristupljeno 5. 12. 2021.

[1]