CHD5

CHD5
Identifikatori
Aliasi	CHD5
Vanjski ID-jevi	OMIM: 610771 MGI: 3036258 HomoloGene: 56712 GeneCards: CHD5
Lokacija gena (čovjek)
Hrom.	Hromosom 1 (čovjek)
Kraj	6,180,321 bp
Lokacija gena (miš)
Hrom.	Hromosom 4 (miš)
Kraj	152,474,651 bp
Obrazac RNK ekspresije
	; ;
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• vezivanje sa DNK; • nucleotide binding; • GO:0008026 helicase activity; • vezivanje iona metala; • H3K27me3 modified histone binding; • hydrolase activity; • ATP binding;
Ćelijska komponenta	• NuRD complex; • membrana; • GO:0035328 heterochromatin; • jedro; • nukleoplazma; • citosol; • nuclear speck;
Biološki proces	• Ćelijska diferencijacija; • GO:0009373 regulation of transcription, DNA-templated; • histone H3-K27 trimethylation; • positive regulation of signal transduction by p53 class mediator; • transcription, DNA-templated; • nervous system development; • Spermatogeneza; • histone H4 acetylation; • cerebral cortex neuron differentiation; • negative regulation of cell population proliferation; • GO:0031497, GO:0006336, GO:0034724, GO:0001301, GO:0007580, GO:0034652, GO:0010847 chromatin organization;
	Izvori:Amigo / QuickGO
Ortolozi
	26038
	269610
	ENSG00000116254
	ENSMUSG00000005045
	Q8TDI0
	A2A8L1
	NM_015557
	NM_001081376; NM_029216; NM_001369243
	NP_056372
	NP_001074845; NP_083492; NP_001356172
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Hromodomensko-helikazno-DNK-vezujući protein 5 jest enzim koji je kod ljudi kodiran genom CHD5 sa hromosoma 1.^[5]^[6]^[7]

Amiokiselininska sekvenca

Dužina polipeptidnog lanca je 1.954 aminokiseline, a molekulska težina 223.050 Da.^[8]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MRGPVGTEEE	LPRLFAEEME	NEDEMSEEED	GGLEAFDDFF	PVEPVSLPKK
KKPKKLKENK	CKGKRKKKEG	SNDELSENEE	DLEEKSESEG	SDYSPNKKKK
KKLKDKKEKK	AKRKKKDEDE	DDNDDGCLKE	PKSSGQLMAE	WGLDDVDYLF
SEEDYHTLTN	YKAFSQFLRP	LIAKKNPKIP	MSKMMTVLGA	KWREFSANNP
FKGSSAAAAA	AAVAAAVETV	TISPPLAVSP	PQVPQPVPIR	KAKTKEGKGP
GVRKKIKGSK	DGKKKGKGKK	TAGLKFRFGG	ISNKRKKGSS	SEEDEREESD
FDSASIHSAS	VRSECSAALG	KKSKRRRKKK	RIDDGDGYET	DHQDYCEVCQ
QGGEIILCDT	CPRAYHLVCL	DPELEKAPEG	KWSCPHCEKE	GIQWEPKDDD
DEEEEGGCEE	EEDDHMEFCR	VCKDGGELLC	CDACPSSYHL	HCLNPPLPEI
PNGEWLCPRC	TCPPLKGKVQ	RILHWRWTEP	PAPFMVGLPG	PDVEPSLPPP
KPLEGIPERE	FFVKWAGLSY	WHCSWVKELQ	LELYHTVMYR	NYQRKNDMDE
PPPFDYGSGD	EDGKSEKRKN	KDPLYAKMEE	RFYRYGIKPE	WMMIHRILNH
SFDKKGDVHY	LIKWKDLPYD	QCTWEIDDID	IPYYDNLKQA	YWGHRELMLG
EDTRLPKRLL	KKGKKLRDDK	QEKPPDTPIV	DPTVKFDKQP	WYIDSTGGTL
HPYQLEGLNW	LRFSWAQGTD	TILADEMGLG	KTVQTIVFLY	SLYKEGHSKG
PYLVSAPLST	IINWEREFEM	WAPDFYVVTY	TGDKESRSVI	RENEFSFEDN
AIRSGKKVFR	MKKEVQIKFH	VLLTSYELIT	IDQAILGSIE	WACLVVDEAH
RLKNNQSKFF	RVLNSYKIDY	KLLLTGTPLQ	NNLEELFHLL	NFLTPERFNN
LEGFLEEFAD	ISKEDQIKKL	HDLLGPHMLR	RLKADVFKNM	PAKTELIVRV
ELSQMQKKYY	KFILTRNFEA	LNSKGGGNQV	SLLNIMMDLK	KCCNHPYLFP
VAAVEAPVLP	NGSYDGSSLV	KSSGKLMLLQ	KMLKKLRDEG	HRVLIFSQMT
KMLDLLEDFL	EYEGYKYERI	DGGITGGLRQ	EAIDRFNAPG	AQQFCFLLST
RAGGLGINLA	TADTVIIYDS	DWNPHNDIQA	FSRAHRIGQN	KKVMIYRFVT
RASVEERITQ	VAKRKMMLTH	LVVRPGLGSK	SGSMTKQELD	DILKFGTEEL
FKDDVEGMMS	QGQRPVTPIP	DVQSSKGGNL	AASAKKKHGS	TPPGDNKDVE
DSSVIHYDDA	AISKLLDRNQ	DATDDTELQN	MNEYLSSFKV	AQYVVREEDG
VEEVEREIIK	QEENVDPDYW	EKLLRHHYEQ	QQEDLARNLG	KGKRIRKQVN
YNDASQEDQE	WQDELSDNQS	EYSIGSEDED	EDFEERPEGQ	SGRRQSRRQL
KSDRDKPLPP	LLARVGGNIE	VLGFNARQRK	AFLNAIMRWG	MPPQDAFNSH
WLVRDLRGKS	EKEFRAYVSL	FMRHLCEPGA	DGAETFADGV	PREGLSRQHV
LTRIGVMSLV	RKKVQEFEHV	NGKYSTPDLI	PEGPEGKKSG	EVISSDPNTP
VPASPAHLLP	APLGLPDKME	AQLGYMDEKD	PGAQKPRQPL	EVQALPAALD
RVESEDKHES	PASKERAREE	RPEETEKAPP	SPEQLPREEV	LPEKEKILDK
LELSLIHSRG	DSSELRPDDT	KAEEKEPIET	QQNGDKEEDD	EGKKEDKKGK
FKFMFNIADG	GFTELHTLWQ	NEERAAVSSG	KIYDIWHRRH	DYWLLAGIVT
HGYARWQDIQ	NDPRYMILNE	PFKSEVHKGN	YLEMKNKFLA	RRFKLLEQAL
VIEEQLRRAA	YLNMTQDPNH	PAMALNARLA	EVECLAESHQ	HLSKESLAGN
KPANAVLHKV	LNQLEELLSD	MKADVTRLPS	MLSRIPPVAA	RLQMSERSIL
SRLTNRAGDP	TIQQGAFGSS	QMYSNNFGPN	FRGPGPGGIV	NYNQMPLGPY
VTDI

Funkcija

Ovaj enzim je dio potporodice hromodomenskog helikaznog DNK-vezujućeg (CHD) proteinskog kompleksa za remodeliranje hromatina zavisnih od ATP-a.

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000116254 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000005045 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Schuster EF, Stoger R (Mar 2002). "CHD5 defines a new subfamily of chromodomain-SWI2/SNF2-like helicases". Mamm Genome. 13 (2): 117–9. doi:10.1007/s00335-001-3042-6. PMID 11889561. S2CID 1694959.
^ Thompson PM, Gotoh T, Kok M, White PS, Brodeur GM (Feb 2003). "CHD5, a new member of the chromodomain gene family, is preferentially expressed in the nervous system". Oncogene. 22 (7): 1002–11. doi:10.1038/sj.onc.1206211. PMID 12592387.
^ "Entrez Gene: CHD5 chromodomain helicase DNA binding protein 5".
^ "UniProt, Q8TDI0" (jezik: engleski). Pristupljeno 23. 11. 2021.

Dopunska literatura

Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
Seki N, Ohira M, Nagase T, et al. (1998). "Characterization of cDNA clones in size-fractionated cDNA libraries from human brain". DNA Res. 4 (5): 345–9. doi:10.1093/dnares/4.5.345. PMID 9455484.
Nagase T, Kikuno R, Ishikawa KI, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (1): 65–73. doi:10.1093/dnares/7.1.65. PMID 10718198.
Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
Bagchi A, Papazoglu C, Wu Y, et al. (2007). "CHD5 is a tumor suppressor at human 1p36". Cell. 128 (3): 459–75. doi:10.1016/j.cell.2006.11.052. PMID 17289567. S2CID 13437928.

Vanjski linkovi

Lokacija ljudskog genoma CHD5 i stranica sa detaljima o genu CHD5 u UCSC Genome Browseru.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000116254 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000005045 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11889561-5] Schuster EF, Stoger R (Mar 2002). "CHD5 defines a new subfamily of chromodomain-SWI2/SNF2-like helicases". Mamm Genome. 13 (2): 117–9. doi:10.1007/s00335-001-3042-6. PMID 11889561. S2CID 1694959.

[pmid12592387-6] Thompson PM, Gotoh T, Kok M, White PS, Brodeur GM (Feb 2003). "CHD5, a new member of the chromodomain gene family, is preferentially expressed in the nervous system". Oncogene. 22 (7): 1002–11. doi:10.1038/sj.onc.1206211. PMID 12592387.

[entrez-7] "Entrez Gene: CHD5 chromodomain helicase DNA binding protein 5".

[UniProt-8] "UniProt, Q8TDI0" (jezik: engleski). Pristupljeno 23. 11. 2021.

[1]

p r u Enzimi
Teme	Aktivno mjesto Alosterna regulacija Difuzijski limitirani enzim EC broj Enzimska kataliza Inhibicija enzimskih reakcija Kinetika enzima Koenzim Kooperativnost Lineweaver–Burkov dijagram Michaelis–Mentenova kinetika Mjesto vezanja Spisak enzima
Tipovi	EC1 Oksidoreduktaze/spisak EC2 Transferaze/spisak EC3 Hidrolaze/spisak EC4 Lijaze/spisak EC5 Izomeraze/spisak EC6 Ligaze/spisak