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8A-PDHQ

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8A-PDHQ
识别信息
  • 8a-phenyldecahydroquinoline
CAS号131556-11-1  checkY
PubChem CID
ChemSpider
UNII
CompTox Dashboard英语CompTox Chemicals Dashboard (EPA)
化学信息
化学式C15H21N
摩尔质量215.34 g·mol−1
3D模型(JSmol英语JSmol
  • C1([C@]23CCCC[C@H]2CCCN3)=CC=CC=C1
  • InChI=1S/C15H21N/c1-2-7-13(8-3-1)15-11-5-4-9-14(15)10-6-12-16-15/h1-3,7-8,14,16H,4-6,9-12H2 checkY
  • Key:QEXADSRMRUUCQJ-UHFFFAOYSA-N checkY

8A-PDHQ(全称:8a-苯基十氢喹啉,英語:8a-Phenyldecahydroquinoline)是一种含氮有机化合物,分子式C15H21N,可作为NMDA受体拮抗剂,1950年代由Parke-Davis开发[1][2][3]

参考文献

[编辑]
  1. ^ US Patent 3035059
  2. ^ Chen, C; Kozikowski, AP; Wood, PL; Reynolds, IJ; Ball, RG; Pang, YP. Synthesis and biological activity of 8a-phenyldecahydroquinolines as probes of PCP's binding conformation. A new PCP-like compound with increased in vivo potency.. Journal of medicinal chemistry. 1992-05-01, 35 (9): 1634–8. PMID 1315871. doi:10.1021/jm00087a020. 
  3. ^ Elhallaoui, M; Laguerre, M; Carpy, A; Ouazzani, FC. Molecular modeling of noncompetitive antagonists of the NMDA receptor: proposal of a pharmacophore and a description of the interaction mode.. Journal of molecular modeling. 2002-02, 8 (2): 65–72. PMID 12032600. doi:10.1007/s00894-001-0067-4.