Can the flow of medicines be improved? Fundamental pharmacokinetic and pharmacological principles toward improving Phase II survival (Q83193912)

From Wikidata

Jump to navigation Jump to search

scientific article published on December 29, 2011

Language	Label	Description	Also known as
default for all languages	No label defined
English	Can the flow of medicines be improved? Fundamental pharmacokinetic and pharmacological principles toward improving Phase II survival	scientific article published on December 29, 2011

Statements

scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22227532%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

Can the flow of medicines be improved? Fundamental pharmacokinetic and pharmacological principles toward improving Phase II survival (English)

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22227532%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

pharmacokinetics

1 reference

based on heuristic

inferred from title

author name string

Paul Morgan

1

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22227532%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

John Arrowsmith

3

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22227532%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

Piet H. Van Der Graaf

2

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A22227532

22 December 2024

Doug E. Feltner

4

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A22227532

22 December 2024

Kira S. Drummond

5

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A22227532

22 December 2024

Craig D. Wegner

6

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A22227532

22 December 2024

Steve D. A. Street

7

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A22227532

22 December 2024

language of work or name

1 reference

National Center for Biotechnology Information

PubMed publication ID

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=22227532

22 December 2024

publication date

29 December 2011

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22227532%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

full work available at URL

https://api.elsevier.com/content/article/PII:S1359644611004776?httpAccept=text/xml

1 reference

10.1016/J.DRUDIS.2011.12.020

https://api.crossref.org/works/10.1016/J.DRUDIS.2011.12.020

22 December 2024

https://api.elsevier.com/content/article/PII:S1359644611004776?httpAccept=text/plain

1 reference

10.1016/J.DRUDIS.2011.12.020

https://api.crossref.org/works/10.1016/J.DRUDIS.2011.12.020

22 December 2024

Drug Discovery Today

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22227532%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

17

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22227532%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

9-10

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22227532%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

419-424

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22227532%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

Can the pharmaceutical industry reduce attrition rates?

1

1 reference

10.1016/J.DRUDIS.2011.12.020

https://api.crossref.org/works/10.1016/J.DRUDIS.2011.12.020

22 December 2024

Phase III and submission failures: 2007–2010

2

1 reference

10.1016/J.DRUDIS.2011.12.020

https://api.crossref.org/works/10.1016/J.DRUDIS.2011.12.020

22 December 2024

Trends in risks associated with new drug development: success rates for investigational drugs

3

1 reference

10.1016/J.DRUDIS.2011.12.020

https://api.crossref.org/works/10.1016/J.DRUDIS.2011.12.020

22 December 2024

Trial watch: Phase II failures: 2008-2010.

4

1 reference

10.1016/J.DRUDIS.2011.12.020

https://api.crossref.org/works/10.1016/J.DRUDIS.2011.12.020

22 December 2024

How to improve R&D productivity: the pharmaceutical industry's grand challenge

5

1 reference

10.1016/J.DRUDIS.2011.12.020

https://api.crossref.org/works/10.1016/J.DRUDIS.2011.12.020

22 December 2024

Assessing the translatability of drug projects: what needs to be scored to predict success?

6

1 reference

10.1016/J.DRUDIS.2011.12.020

https://api.crossref.org/works/10.1016/J.DRUDIS.2011.12.020

22 December 2024

Physiologically-Based Pharmacokinetics in Drug Development and Regulatory Science

7

1 reference

10.1016/J.DRUDIS.2011.12.020

https://api.crossref.org/works/10.1016/J.DRUDIS.2011.12.020

22 December 2024

Quantitative pharmacological analysis of antagonist binding kinetics at CRF1 receptors in vitro and in vivo

8

1 reference

10.1016/J.DRUDIS.2011.12.020

https://api.crossref.org/works/10.1016/J.DRUDIS.2011.12.020

22 December 2024

Double-blind, crossover comparison of 3 mg apomorphine SL with placebo and with 4 mg apomorphine SL in male erectile dysfunction

9

1 reference

10.1016/J.DRUDIS.2011.12.020

https://api.crossref.org/works/10.1016/J.DRUDIS.2011.12.020

22 December 2024

Pharmacokinetics and elucidation of the rates and routes of N-glucuronidation of PF-592379, an oral dopamine 3 agonist in rat, dog, and human

11

1 reference

10.1016/J.DRUDIS.2011.12.020

https://api.crossref.org/works/10.1016/J.DRUDIS.2011.12.020

22 December 2024

Systems Pharmacology: Bridging Systems Biology and Pharmacokinetics-Pharmacodynamics (PKPD) in Drug Discovery and Development

12

1 reference

10.1016/J.DRUDIS.2011.12.020

https://api.crossref.org/works/10.1016/J.DRUDIS.2011.12.020

22 December 2024

HIV-1 entry into CD4+ cells is mediated by the chemokine receptor CC-CKR-5

13

1 reference

10.1016/J.DRUDIS.2011.12.020

https://api.crossref.org/works/10.1016/J.DRUDIS.2011.12.020

22 December 2024

Homozygous defect in HIV-1 coreceptor accounts for resistance of some multiply-exposed individuals to HIV-1 infection

14

1 reference

10.1016/J.DRUDIS.2011.12.020

https://api.crossref.org/works/10.1016/J.DRUDIS.2011.12.020

22 December 2024

The effects of the 32-bp CCR-5 deletion on HIV transmission and HIV disease progression in individuals with haemophilia

15

1 reference

10.1016/J.DRUDIS.2011.12.020

https://api.crossref.org/works/10.1016/J.DRUDIS.2011.12.020

22 December 2024

Chemokine receptors as HIV-1 coreceptors: roles in viral entry, tropism, and disease

16

1 reference

10.1016/J.DRUDIS.2011.12.020

https://api.crossref.org/works/10.1016/J.DRUDIS.2011.12.020

22 December 2024

SCH-C (SCH 351125), an orally bioavailable, small molecule antagonist of the chemokine receptor CCR5, is a potent inhibitor of HIV-1 infection in vitro and in vivo

17

1 reference

10.1016/J.DRUDIS.2011.12.020

https://api.crossref.org/works/10.1016/J.DRUDIS.2011.12.020

22 December 2024

Maraviroc (UK-427,857), a potent, orally bioavailable, and selective small-molecule inhibitor of chemokine receptor CCR5 with broad-spectrum anti-human immunodeficiency virus type 1 activity

18

1 reference

10.1016/J.DRUDIS.2011.12.020

https://api.crossref.org/works/10.1016/J.DRUDIS.2011.12.020

22 December 2024

Species differences in the disposition of the CCR5 antagonist, UK-427,857, a new potential treatment for HIV.

19

1 reference

10.1016/J.DRUDIS.2011.12.020

https://api.crossref.org/works/10.1016/J.DRUDIS.2011.12.020

22 December 2024

Virus dynamics and drug therapy

20

1 reference

10.1016/J.DRUDIS.2011.12.020

https://api.crossref.org/works/10.1016/J.DRUDIS.2011.12.020

22 December 2024

A pharmacokinetic-pharmacodynamic disease model to predict in vivo antiviral activity of maraviroc

21

1 reference

10.1016/J.DRUDIS.2011.12.020

https://api.crossref.org/works/10.1016/J.DRUDIS.2011.12.020

22 December 2024

A pharmacokinetic-pharmacodynamic model to optimize the phase IIa development program of maraviroc

22

1 reference

10.1016/J.DRUDIS.2011.12.020

https://api.crossref.org/works/10.1016/J.DRUDIS.2011.12.020

22 December 2024

Pharmacodynamic-pharmacokinetic integration as a guide to medicinal chemistry

23

1 reference

10.1016/J.DRUDIS.2011.12.020

https://api.crossref.org/works/10.1016/J.DRUDIS.2011.12.020

22 December 2024

Lessons learned from candidate drug attrition

24

1 reference

10.1016/J.DRUDIS.2011.12.020

https://api.crossref.org/works/10.1016/J.DRUDIS.2011.12.020

22 December 2024

Proof of concept: a PhRMA position paper with recommendations for best practice

25

1 reference

10.1016/J.DRUDIS.2011.12.020

https://api.crossref.org/works/10.1016/J.DRUDIS.2011.12.020

22 December 2024

Pharmacokinetic and pharmacodynamic data to be derived from early-phase drug development: designing informative human pharmacology studies

26

1 reference

10.1016/J.DRUDIS.2011.12.020

https://api.crossref.org/works/10.1016/J.DRUDIS.2011.12.020

22 December 2024

Identifiers

10.1016/J.DRUDIS.2011.12.020

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22227532%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22227532%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q83193912&oldid=2290331874"