KEGG   DRUG: Omeprazole magnesium, amoxicillin and rifabutin
Entry
D11858            Mixture   Drug                                   
Name
Omeprazole magnesium, amoxicillin and rifabutin;
Talicia (TN)
Product
TALICIA (RedHill Biopharma)
Component
Omeprazole magnesium [DR:D05259], (Amoxicillin [DR:D00229] | Amoxicillin [DR:D07452]), Rifabutin [DR:D00424]
Class
Metabolizing enzyme substrate
 DG01639  CYP2C19 substrate
 DG01633  CYP3A/CYP3A4 substrate
Metabolizing enzyme inhibitor
 DG01933  CYP2C19 inhibitor
Metabolizing enzyme inducer
 DG02853  CYP3A/CYP3A4 inducer
Remark
ATC code: A02BD16
Product: D11858<US>
Efficacy
Antibacterial
  Disease
Helicobacter pylori infection [DS:H00320]
Comment
Rifabutin is a substrate and an inducer of CYP3A.
Omeprazole is a substrate and an inhibitor of CYP2C19, and a substrate of CYP3A4.
Metabolism
Enzyme: CYP3A [HSA:1576 1577 1551], CYP2C19 [HSA:1557]
Interaction
CYP induction: CYP3A [HSA:1576 1577 1551]
CYP inhibition: CYP2C19 [HSA:1557]
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A02 DRUGS FOR ACID RELATED DISORDERS
   A02B DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD)
    A02BD Combinations for eradication of Helicobacter pylori
     A02BD16 Omeprazole, amoxicillin and rifabutin
      D11858  Omeprazole magnesium, amoxicillin and rifabutin <US>
USP drug classification [BR:br08302]
 Gastrointestinal Agents
  Gastrointestinal Agents, Other
   Amoxicillin/ Omeprazole Magnesium/ Rifabutin
    D11858  Omeprazole magnesium, amoxicillin and rifabutin
Drug groups [BR:br08330]
 Metabolizing enzyme substrate
  DG01639  CYP2C19 substrate
   D11858  Omeprazole magnesium, amoxicillin and rifabutin
  DG01633  CYP3A/CYP3A4 substrate
   D11858  Omeprazole magnesium, amoxicillin and rifabutin
 Metabolizing enzyme inhibitor
  DG01933  CYP2C19 inhibitor
   D11858  Omeprazole magnesium, amoxicillin and rifabutin
 Metabolizing enzyme inducer
  DG02853  CYP3A/CYP3A4 inducer
   D11858  Omeprazole magnesium, amoxicillin and rifabutin
Antimicrobials [BR:br08307]
 Antibacterials
  Cell wall biosynthesis inhibitor, beta-lactam
   Combination for eradication of H. pylori
    D11858  Omeprazole magnesium, amoxicillin and rifabutin <US>
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D11858
Other DBs
PubChem: 433774533
LinkDB

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