Entry |
|
Name |
Rifabutin (JAN/USP/INN); Mycobutin (TN) |
Abbr |
RFB |
Product |
|
Generic |
|
Formula |
C46H62N4O11
|
Exact mass |
846.4415
|
Mol weight |
847.00
|
Structure |

|
Simcomp |
|
Class |
Antibacterial
DG01966 Antitubercular
DG01598 Rifamycin antibiotic
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
Metabolizing enzyme inducer
DG02853 CYP3A/CYP3A4 inducer
|
Remark |
Therapeutic category: | 6169 |
Product (mixture): | D11858<US> |
|
Efficacy |
Antibacterial (antimycobacterial), RNA polymerase inhibitor |
Comment |
Rifamycin derivative
|
Target |
|
Pathway |
|
Metabolism |
Enzyme: CYP3A4 [HSA: 1576]
|
Interaction |
|
Structure map |
|
Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
J ANTIINFECTIVES FOR SYSTEMIC USE
J04 ANTIMYCOBACTERIALS
J04A DRUGS FOR TREATMENT OF TUBERCULOSIS
J04AB Antibiotics
J04AB04 Rifabutin
D00424 Rifabutin (JAN/USP/INN) <JP/US>
USP drug classification [BR:br08302]
Antimycobacterials
Antimycobacterials, Other
Rifabutin
D00424 Rifabutin (JAN/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
6 Agents against pathologic organisms and parasites
61 Antibiotics
616 Acting mainly on acid-fast bacteria
6169 Others
D00424 Rifabutin (JAN/USP/INN)
Drug groups [BR:br08330]
Antibacterial
DG01966 Antitubercular
DG01598 Rifamycin antibiotic
D00424 Rifabutin
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
D00424 Rifabutin
Metabolizing enzyme inducer
DG02853 CYP3A/CYP3A4 inducer
D00424 Rifabutin
Antimicrobials [BR:br08307]
Antibacterials
Nucleic acid synthesis inhibitor
Rifamycin
D00424 Rifabutin (JAN/USP/INN) <JP/US>
Antimicrobials abbreviations [BR:br08327]
Antibacterials
Nucleic acid synthesis inhibitor
Rifamycin
D00424 Rifabutin (JAN/USP/INN)
New drug approvals in Japan [br08318.html]
Drugs with new active ingredients
D00424
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D00424
|
Other DBs |
|
LinkDB |
|
KCF data |
ATOM 61
1 C1c C 21.8400 -4.9000
2 C1c C 21.8400 -6.3700
3 O1a O 24.2900 -6.3000
4 C1c C 24.2900 -4.9000
5 C1c C 23.0300 -4.2000
6 C2b C 26.6700 -4.9000
7 C1c C 25.4800 -4.2000
8 C5a C 27.9300 -7.0700
9 C2c C 29.1200 -6.3700
10 C2b C 29.1200 -4.9000
11 C2b C 27.9300 -4.2000
12 C1a C 25.4800 -2.8000
13 C1a C 23.0300 -2.8000
14 O1a O 20.6500 -4.2000
15 C1a C 30.3100 -7.0700
16 O5a O 26.7400 -6.3700
17 N1b N 27.9300 -8.7500
18 C1c C 20.6500 -7.0700
19 O7a O 19.4600 -6.3700
20 C1c C 20.6500 -8.7500
21 C2y C 26.7400 -9.4500
22 C2y C 26.7400 -10.8500
23 C5x C 25.4800 -8.7500
24 C8y C 24.2900 -9.4500
25 C8y C 24.2900 -10.8500
26 C2y C 25.4800 -11.5500
27 C8y C 23.1000 -8.7500
28 C8y C 21.8400 -9.4500
29 C8y C 21.8400 -10.8500
30 C8y C 23.1000 -11.5500
31 O5x O 25.4800 -7.3500
32 O1a O 23.1000 -7.3500
33 C1a C 20.6500 -5.2500
34 C7a C 18.2000 -5.6700
35 C1a C 17.0100 -6.3700
36 O6a O 18.2000 -4.2700
37 N2x N 25.4800 -12.9500
38 C1z C 28.0000 -12.9500
39 N1x N 28.0000 -11.5500
40 C1x C 28.0000 -14.3500
41 C1x C 29.2124 -15.0500
42 N1y N 30.4249 -14.3500
43 C1x C 30.4249 -12.9500
44 C1x C 29.2124 -12.2500
45 C1b C 31.6560 -15.0610
46 C1c C 32.8612 -14.3653
47 C1a C 34.0435 -15.0481
48 C1a C 32.8616 -12.9504
49 C1c C 19.4376 -9.4500
50 O2a O 18.2421 -8.7596
51 C2b C 19.4375 -10.8498
52 C1a C 19.4376 -7.7700
53 C1a C 17.0547 -9.4451
54 C2b C 18.2419 -11.5402
55 O2a O 18.2419 -12.9402
56 O2x O 20.6334 -11.5600
57 C1z C 20.6334 -12.9600
58 C5x C 23.1000 -12.9500
59 O5x O 24.0919 -13.9379
60 C1a C 20.6334 -14.3600
61 C1a C 21.8400 -8.0500
BOND 66
1 1 2 1
2 4 3 1 #Down
3 4 5 1
4 1 5 1
5 6 7 1
6 4 7 1
7 8 9 1
8 9 10 2
9 10 11 1
10 6 11 2
11 7 12 1 #Up
12 5 13 1 #Down
13 1 14 1 #Down
14 9 15 1
15 8 16 2
16 8 17 1
17 2 18 1
18 18 19 1 #Up
19 18 20 1
20 17 21 1
21 21 22 2
22 21 23 1
23 23 24 1
24 24 25 1
25 25 26 1
26 24 27 2
27 27 28 1
28 28 29 2
29 29 30 1
30 25 30 2
31 23 31 2
32 27 32 1
33 2 33 1 #Up
34 19 34 1
35 34 35 1
36 34 36 2
37 37 38 1
38 38 39 1
39 39 22 1
40 26 37 2
41 26 22 1
42 38 40 1
43 40 41 1
44 41 42 1
45 42 43 1
46 43 44 1
47 38 44 1
48 42 45 1
49 45 46 1
50 46 47 1
51 46 48 1
52 20 49 1
53 49 50 1 #Down
54 49 51 1
55 20 52 1 #Down
56 50 53 1
57 51 54 2
58 54 55 1
59 29 56 1
60 56 57 1
61 55 57 1
62 30 58 1
63 57 58 1
64 58 59 2
65 57 60 1 #Down
66 28 61 1
|