Gentamicin 3'-N-acetiltransferaza
| Gentamicin 3'-N-acetiltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.3.1.60 | ||||||||
| CAS broj | 58500-58-6 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Gentamicin 3'-N-acetiltransferaza (EC 2.3.1.60, gentamicinska acetiltransferaza I, aminoglikozidna acetiltransferaza AAC(3)-1, gentamicinska 3'-N-acetiltransferaza, acetil-KoA:gentamicin-C N3'-acetiltransferaza) je enzim sa sistematskim imenom acetil-KoA:gentamicin-C N3'-acetiltransferaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- acetil-KoA + gentamicin C KoA + N3'-acetilgentamicin C
Ovaj enzim takođe acetiluje sisomicin.
Reference
[уреди | уреди извор]- ^ Angelatou, F., Litsas, S.B. and Kontomichalou, P. (1982). „Purification and properties of two gentamicin-modifying enzymes, coded by a single plasmid pPK237 originating from Pseudomonas aeruginosa”. J. Antibiot. 35: 235—244. PMID 6281224.
- ^ Biddlecome, S., Haas, J., Davies, G.H., Miller, D., Rane, F. and Daniels, P.J.L. (1976). „Enzymatic modification of aminoglycoside antibiotics: a new 3-N-acetylating enzyme from a Pseudomonas aeruginosa isolate”. Antimicrob. Agents Chemother. 9: 951—955. PMID 820250.
- ^ Williams, J.W. & Northrop, D.B. (1976). „Purification and properties of gentamicin acetyltransferase I”. Biochemistry. 15: 125—131. PMID 764855.
Literatura
[уреди | уреди извор]- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze
[уреди | уреди извор]- Gentamicin+3'-N-acetyltransferase на US National Library of Medicine Medical Subject Headings (MeSH)
