23S rRNK (adenin1618-N6)-metiltransferaza
| 23S rRNK (adenin1618-N6)-metiltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.1.1.181 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
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23S rRNK (adenin1618-N6)-metiltransferaza (EC 2.1.1.181, metiltransferaza F velike podjedinice rRNK, YbiN protein, rlmF (gen), m6A1618 metiltransferaza) je enzim sa sistematskim imenom S-adenozil-L-metionin:23S rRNK (adenin1618-N6)-metiltransferaza.[1] Ovaj enzim katalizuje sledeću hemijsku reakciju
- S-adenozil-L-metionin + adenin1618 u 23S rRNK S-adenozil-L-homocistein + N6-metiladenin1618 u 23S rRNK
Rekombinantni YbiN protein ima sposobnost metilacije parcijalno deprotonisane 50 S ribozomalne podjedinice. On ne deluje na kompletno formirane 50 S podjednice, niti na kompletno deprotonisanu 23 S rRNK.
Reference
[уреди | уреди извор]- ^ Sergiev, P.V., Serebryakova, M.V., Bogdanov, A.A. and Dontsova, O.A. (2008). „The ybiN gene of Escherichia coli encodes adenine-N6 methyltransferase specific for modification of A1618 of 23 S ribosomal RNA, a methylated residue located close to the ribosomal exit tunnel”. J. Mol. Biol. 375: 291—300. PMID 18021804.
Literatura
[уреди | уреди извор]- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze
[уреди | уреди извор]- 23S+rRNA+(adenine1618-N6)-methyltransferase на US National Library of Medicine Medical Subject Headings (MeSH)
