IronPython

print "Hello World"

#!/usr/bin/env ipy
#-*- coding: UTF-8 -*-

import clr
clr.AddReference('gtk-sharp')
import Gtk

def button_clicked(button, args):
    print('Привет Мир!')

def main():
    Gtk.Application.Init()

    window = Gtk.Window('Окно Приветствия')
    window.SetDefaultSize(240, 180)
    window.DeleteEvent += lambda w, a: Gtk.Application.Quit()

    button = Gtk.Button('Нажми Меня')
    button.Clicked += button_clicked
    button.Show()

    window.Add(button)
    window.Present()

    Gtk.Application.Run()

if __name__ == '__main__':
    main()