Interleukin-18

IL18
Struktur yang tersedia
PDB	Pencarian Ortolog: PDBe RCSB
Daftar kode id PDB
	1J0S, 2VXT, 3F62, 4EEE, 4EKX, 4HJJ, 3WO2, 3WO3, 3WO4, 4R6U, 4XFS, 4XFT, 4XFU
Pengidentifikasi
Alias	IL18, IGIF, IL-18, IL-1g, IL1F4, interleukin 18
ID eksternal	OMIM: 600953 MGI: 107936 HomoloGene: 1200 GeneCards: IL18
Lokasi gen (Manusia)
Kr.	Kromosom 11 (manusia)
Akhir	112,164,096 bp
Lokasi gen (Tikus)
Kr.	Kromosom 9 (tikus)
Akhir	50,493,140 bp
Pola ekspresi RNA
	Referensi data ekspresi selengkapnya
Ontologi gen
Fungsi molekuler	• GO:0001948, GO:0016582 Ikatan protein plasma; • cytokine activity; • interleukin-18 receptor binding;
Komponen seluler	• sitosol; • extracellular region; • extracellular space;
Proses biologis	• positive regulation of inflammatory response; • cell-cell signaling; • GO:1904579 cellular response to organic cyclic compound; • type 2 immune response; • MAPK cascade; • positive regulation of natural killer cell proliferation; • Tidur; • regulation of cell adhesion; • positive regulation of NK T cell proliferation; • positive regulation of granulocyte macrophage colony-stimulating factor production; • positive regulation of tissue remodeling; • Angiogenesis; • T-helper 1 type immune response; • positive regulation of interleukin-17 production; • inflammatory response; • lipopolysaccharide-mediated signaling pathway; • positive regulation of activated T cell proliferation; • positive regulation of protein kinase B signaling; • positive regulation of phosphatidylinositol 3-kinase signaling; • positive regulation of smooth muscle cell proliferation; • activation of protein kinase B activity; • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II; • positive regulation of tyrosine phosphorylation of STAT protein; • GO:1901313 positive regulation of gene expression; • positive regulation of macrophage derived foam cell differentiation; • natural killer cell activation; • positive regulation of interferon-gamma production; • cholesterol homeostasis; • positive regulation of T-helper 2 cell differentiation; • negative regulation of myoblast differentiation; • triglyceride homeostasis; • cell population proliferation; • regulation of signaling receptor activity; • interleukin-6 production; • T-helper 1 cell cytokine production; • neutrophil activation; • natural killer cell mediated cytotoxicity; • cytokine-mediated signaling pathway; • interleukin-18-mediated signaling pathway; • positive regulation of NIK/NF-kappaB signaling; • GO:0046730, GO:0046737, GO:0046738, GO:0046736 respons imun; • positive regulation of NF-kappaB transcription factor activity; • positive regulation of T-helper 1 cell cytokine production; • positive regulation of cold-induced thermogenesis; • positive regulation of neuroinflammatory response; • GO:0072468 signal transduction;
	Sumber:Amigo / QuickGO
Ortolog
	3606
	16173
	ENSG00000150782
	ENSMUSG00000039217
	Q14116
	P70380
	NM_001243211; NM_001562; NM_001386420
	NM_008360; NM_001357221; NM_001357222
	NP_001230140; NP_001553; NP_001230140.1
	NP_032386; NP_001344150; NP_001344151
	Wikidata
Lihat/Sunting Manusia	Lihat/Sunting Tikus

Interleukin-18 (bahasa Inggris: interleukin-18, interferon-gamma-inducing factor, IL-18) adalah sitokina yang merupakan ekspresi genetik IL18,^[5] dengan prekursor sepanjang 192 AA dan protein aktif sepanjang 157 AA yang meningkatkan respon peradangan tubuh dengan menginduksi sekresi interferon-gamma oleh sel T dan meningkatkan aktivitas sel NK di dalam limpa. IL-18 umumnya merupakan sekresi makrofaga dan sel Kupffer.^[6]

Peningkatan ekspresi IL-18 ditemukan pada beberapa jenis kanker, adenomiosis,^[7] dan Hashimoto tiroiditis.^[8]

Lihat pula

Asam askorbat

Rujukan

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000150782 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000039217 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ (Inggris) "IL18 interleukin 18 (interferon-gamma-inducing factor) [ Homo sapiens ]". Entrez Gene. Diakses tanggal 2010-11-28.
^ (Inggris) "Cloning of a new cytokine that induces IFN-gamma production by T cells". Department of Bacteriology, Hyogo College of Medicine; Okamura H, Tsutsi H, Komatsu T, Yutsudo M, Hakura A, Tanimoto T, Torigoe K, Okura T, Nukada Y, Hattori K, et al. Diakses tanggal 2010-11-28.
^ (Inggris) "Eutopic endometrial interleukin-18 system mRNA and protein expression at the level of endometrial-myometrial interface in adenomyosis patients". Department of Obstetrics and Gynecology, Lin-Kou Medical Center, Chang Gung Memorial Hospital; Huang HY, Yu HT, Chan SH, Lee CL, Wang HS, Soong YK. Diakses tanggal 2010-11-28.
^ (Inggris) "Thyrocyte interleukin-18 expression is up-regulated by interferon-γ and may contribute to thyroid destruction in Hashimoto's thyroiditis". Department of Endocrinology and Metabolism, Peking University Third Hospital; Liu Z, Wang H, Xiao W, Wang C, Liu G, Hong T. Diakses tanggal 2010-11-28.

Artikel bertopik biokimia ini adalah sebuah rintisan. Anda dapat membantu Wikipedia dengan mengembangkannya.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000150782 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000039217 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] (Inggris) "IL18 interleukin 18 (interferon-gamma-inducing factor) [ Homo sapiens ]". Entrez Gene. Diakses tanggal 2010-11-28.

[6] (Inggris) "Cloning of a new cytokine that induces IFN-gamma production by T cells". Department of Bacteriology, Hyogo College of Medicine; Okamura H, Tsutsi H, Komatsu T, Yutsudo M, Hakura A, Tanimoto T, Torigoe K, Okura T, Nukada Y, Hattori K, et al. Diakses tanggal 2010-11-28.

[7] (Inggris) "Eutopic endometrial interleukin-18 system mRNA and protein expression at the level of endometrial-myometrial interface in adenomyosis patients". Department of Obstetrics and Gynecology, Lin-Kou Medical Center, Chang Gung Memorial Hospital; Huang HY, Yu HT, Chan SH, Lee CL, Wang HS, Soong YK. Diakses tanggal 2010-11-28.

[8] (Inggris) "Thyrocyte interleukin-18 expression is up-regulated by interferon-γ and may contribute to thyroid destruction in Hashimoto's thyroiditis". Department of Endocrinology and Metabolism, Peking University Third Hospital; Liu Z, Wang H, Xiao W, Wang C, Liu G, Hong T. Diakses tanggal 2010-11-28.

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