Jump to content

NKX6-1

From Wikipedia, the free encyclopedia
NKX6-1
Identifiers
AliasesNKX6-1, NKX6.1, NKX6A, NK6 homeobox 1
External IDsOMIM: 602563; MGI: 1206039; HomoloGene: 4495; GeneCards: NKX6-1; OMA:NKX6-1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_006168

NM_144955

RefSeq (protein)

NP_006159

NP_659204

Location (UCSC)Chr 4: 84.49 – 84.5 MbChr 5: 101.81 – 101.81 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Homeobox protein Nkx-6.1 is a protein that in humans is encoded by the NKX6-1 gene.[5][6]

Function

[edit]

In the pancreas, NKX6.1 is required for the development of beta cells and is a potent bifunctional transcription regulator that binds to AT-rich sequences within the promoter region of target genes.[6]

References

[edit]
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000163623Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000035187Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Inoue H, Rudnick A, German MS, Veile R, Donis-Keller H, Permutt MA (March 1997). "Isolation, characterization, and chromosomal mapping of the human Nkx6.1 gene (NKX6A), a new pancreatic islet homeobox gene". Genomics. 40 (2): 367–70. doi:10.1006/geno.1996.4568. PMID 9119408.
  6. ^ a b "Entrez Gene: NK6 homeobox 1".

Further reading

[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.