Talk:Propylhexedrine

This review is transcluded from Talk:Propylhexedrine/GA1. The edit link for this section can be used to add comments to the review.

Reviewer: AryKun (talk · contribs) 16:39, 18 July 2023 (UTC)Reply

Hey AryKun,

Just checking in. How’s the article look?

Thanks,

JoeBo82 JoeBo82 (talk) 19:27, 22 July 2023 (UTC)Reply

This article has failed its Good article nomination. This is how the article, as of July 25, 2023, compares against the six good article criteria:

1. Well written?: n

2. Verifiable?: y

3. Broad in coverage?: n

4. Neutral point of view?: y

5. Stable?: y

6. Images?: y

When these issues are addressed, the article can be renominated. If you feel that this review is in error, feel free to have it reassessed. Thank you for your work so far.

• I am inclined towards failing the article at this time due to a lack of thoroughness, dense prose that is not clear to a lay audience, and more importantly, a lack of compliance with WP:MEDRS.
• The sections on recreational abuse are sourced almost entirely to decades-old primary reports instead of newer literature review such as 1 and 2 (same authors for both papers, and more or less the same content). Additionally, there are a number of questionable sources such as cornucopeia.cn, misrepresented sources such as a Merriam-Webster definition for alkylamine citing propylhexedrine being a alkylamine, and the overall issue of the median age of sources appearing to be sometime around the 1980's.
• The prose is also dense and incomprehensible to a lay audience: I don't think the article should require anything beyond a perhaps advanced high school level of chemistry and biology to understand. The Interactions, Mechanism of action, Synthesis, and Detection in bodily fluids are very heavy in advanced terms with almost no effort to explain what, for example, a sympathomimetic is.
• You are free to nominate the article again after addressing the issues raised above or if you disagree with my review. AryKun (talk) 14:06, 25 July 2023 (UTC)Reply

"Freebase propylhexedrine is a volatile, oily liquid at room temperature. The slow evaporation of freebase propylhexedrine allows it to be administered via inhalation. The evaporation of the freebase also accounts for the limited shelf-life of propylhexedrine inhalers. Many of the salts of propylhexedrine are stable, clear to off-white crystalline substances that readily dissolve in water." I cannot verify this passage in ref:

• [32] US granted 4095596, Grayson M, "Nasal Inhaler", issued 20 June 1978, assigned to Smithkline Corp
• [33] Mancusi-Ungaro HR, Decker WJ, Forshan VR, Blackwell SJ, Lewis SR (1983). "Tissue injuries associated with parenteral propylhexedrine abuse". Journal of Toxicology. Clinical Toxicology. 21 (3): 359–372. doi:10.1097/00005373-198307000-00114. PMID 6144800.

Mongrangvebet (talk) 13:31, 19 May 2024 (UTC)Reply

The first reference serves to prove that propylhexedrine gradually escapes from an inhaler, which gives a standard nasal inhaler with it as the active ingredient a limited shelf-life. The second indicates that the ingredient is "relatively pure propylhexedrine hydrochloride" which is freebase propylhexedrine. It also demonstrates that the salt was soluble in water. I don't know if there is an indication of the color and solubility of other salts, since it looks like that second reference may be longer than the abstract I can see? Reconrabbit 14:37, 19 May 2024 (UTC)Reply

The second ref ([33]) (free accessed) links to page 650. It should link to page 359–372. I recommend use this ref <ref>{{Cite journal|vauthors=Mancusi-Ungaro HR, Decker WJ, Forshan VR, Blackwell SJ, Lewis SR |year=1983 |title=Tissue injuries associated with parenteral propylhexedrine abuse |journal=Journal of Toxicology. Clinical Toxicology |volume=21 |issue=3 |pages=359–372 |doi=10.1097/00005373-198307000-00114 |pmid=6144800}}</ref> Mongrangvebet (talk) 18:34, 19 May 2024 (UTC)Reply

I see this is coming up in the routes of administration. I'm not personally aware of any contemporary preparations of propylhexedrine that are available in any form other than an inhalant. Not to say that an inhaler couldn't be tampered with to be administered in a different way. Since the infobox should reflect the full text of the article, it should be trivial to find a reference under the recreational use header to justify describing the routes of recreational administration as "oral, parenteral". As it is I can only find references that recommend against using any route other than inhalation and not any specific ones. Or am I missing something? Reconrabbit 12:08, 29 July 2024 (UTC)Reply

There are references under the "Recreational use" that describe recreational use as including intravenous means, such as the aptly titled "Intravenous Abuse of Propylhexedrine (Benzedrex®) and the Risk of Brainstem Dysfunction in Young Adults" reference currently cited as reference [65] on the page. In addition, reference [21] mentions the following: "There have been many reports of toxicity associated with propylhexedrine extracted from an inhaler and swallowed or injected. Swallowing the contents of one propylhexedrine inhaler has caused heart attack and lung injury in adults and children [emphasis added]." The reason there are not citations in the infobox is mainly for convenience, as editing such citations in the infobox is more cumbersome than simply editing them in the article body where it is relevant. Irruptive Creditor (talk) 21:11, 30 July 2024 (UTC)Reply

So I did miss that. I've never thought about breaking open an inhaler to get at the stuff inside, but there are a lot of things I haven't tried. Hopefully the infobox argument can be put to rest. Reconrabbit 12:37, 31 July 2024 (UTC)Reply