PCDH10

PCDH10
Identifiers
Aliases	PCDH10, OL-PCDH, PCDH19, protocadherin 10
External IDs	OMIM: 608286; MGI: 1338042; HomoloGene: 74967; GeneCards: PCDH10; OMA:PCDH10 - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	133,208,606 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	45,390,058 bp
RNA expression pattern
	Top expressed in
	endothelial cell; ; prefrontal cortex; ; internal globus pallidus; ; Brodmann area 46; ; caudate nucleus; ; nucleus accumbens; ; superior frontal gyrus; ; Brodmann area 23; ; stromal cell of endometrium; ; putamen;
	Top expressed in
	substantia nigra; ; olfactory tubercle; ; lateral hypothalamus; ; globus pallidus; ; dorsomedial hypothalamic nucleus; ; primary motor cortex; ; superior frontal gyrus; ; paraventricular nucleus of hypothalamus; ; nucleus accumbens; ; medial dorsal nucleus;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	calcium ion binding;
Cellular component	integral component of membrane; plasma membrane; membrane; integral component of plasma membrane;
Biological process	homophilic cell adhesion via plasma membrane adhesion molecules; cell adhesion; cell-cell signaling; nervous system development;
	Sources:Amigo / QuickGO
Orthologs
	57575
	18526
	ENSG00000138650
	ENSMUSG00000049100
	Q9P2E7
	n/a
	NM_020815; NM_032961
	NM_001098170; NM_001098171; NM_001098172; NM_011043
	NP_065866; NP_116586
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Protocadherin-10 is a protein that in humans is encoded by the PCDH10 gene.^[5]^[6]

This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. The mRNA encodes a cadherin-related neuronal receptor thought to play a role in the establishment and function of specific cell-cell connections in the brain. This family member contains 6 extracellular cadherin domains, a transmembrane domain and a cytoplasmic tail differing from those of the classical cadherins. Alternatively spliced transcripts encode isoforms with unique cytoplasmic domains.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000138650 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000049100 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Nollet F, Kools P, van Roy F (Jul 2000). "Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members". J Mol Biol. 299 (3): 551–72. doi:10.1006/jmbi.2000.3777. PMID 10835267.
^ ^a ^b "Entrez Gene: PCDH10 protocadherin 10".

Yagi T, Takeichi M (2000). "Cadherin superfamily genes: functions, genomic organization, and neurologic diversity". Genes Dev. 14 (10): 1169–80. doi:10.1101/gad.14.10.1169. PMID 10817752. S2CID 44844497.
Cross SH, Charlton JA, Nan X, Bird AP (1994). "Purification of CpG islands using a methylated DNA binding column". Nat. Genet. 6 (3): 236–44. doi:10.1038/ng0394-236. PMID 8012384. S2CID 12847618.
Wu Q, Maniatis T (1999). "A striking organization of a large family of human neural cadherin-like cell adhesion genes". Cell. 97 (6): 779–90. doi:10.1016/S0092-8674(00)80789-8. PMID 10380929. S2CID 6014717.
Wu Q, Maniatis T (2000). "Large exons encoding multiple ectodomains are a characteristic feature of protocadherin genes". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3124–9. doi:10.1073/pnas.060027397. PMC 16203. PMID 10716726.
Nagase T, Kikuno R, Ishikawa KI, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (1): 65–73. doi:10.1093/dnares/7.1.65. PMID 10718198.
Wu Q, Zhang T, Cheng JF, et al. (2001). "Comparative DNA Sequence Analysis of Mouse and Human Protocadherin Gene Clusters". Genome Res. 11 (3): 389–404. doi:10.1101/gr.167301. PMC 311048. PMID 11230163.
Wolverton T, Lalande M (2001). "Identification and characterization of three members of a novel subclass of protocadherins". Genomics. 76 (1–3): 66–72. doi:10.1006/geno.2001.6592. PMID 11549318.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ying J, Li H, Seng TJ, et al. (2006). "Functional epigenetics identifies a protocadherin PCDH10 as a candidate tumor suppressor for nasopharyngeal, esophageal and multiple other carcinomas with frequent methylation". Oncogene. 25 (7): 1070–80. doi:10.1038/sj.onc.1209154. PMID 16247458. S2CID 11573872.

This article on a gene on human chromosome 4 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000138650 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000049100 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10835267-5] Nollet F, Kools P, van Roy F (Jul 2000). "Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members". J Mol Biol. 299 (3): 551–72. doi:10.1006/jmbi.2000.3777. PMID 10835267.

[entrez-6] "Entrez Gene: PCDH10 protocadherin 10".

[5]

PCDH10

References

Further reading