Lithium citrate

Lithium citrate
Names
	Other names Trilithium citrate; trilithium 2-hydroxypropane-1,2,3-tricarboxylate
Identifiers
CAS Number	919-16-4 ;
3D model (JSmol)	Interactive image;
ChEBI	CHEBI:64735;
ChEMBL	ChEMBL1201170 ;
ChemSpider	12932 ;
DrugBank	DB14507;
ECHA InfoCard	100.011.860
EC Number	213-045-8;
PubChem CID	13520;
RTECS number	TZ8616000;
UNII	3655633623 ;
CompTox Dashboard (EPA)	DTXSID70883185 ;
	InChI InChI=1S/C6H8O7.3Li/c7-3(8)1-6(13,5(11)12)2-4(9)10;;;/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12);;;/q;3+1/p-3 Key: WJSIUCDMWSDDCE-UHFFFAOYSA-K ; InChI=1/C6H8O7.3Li/c7-3(8)1-6(13,5(11)12)2-4(9)10;;;/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12);;;/q;3+1/p-3 Key: WJSIUCDMWSDDCE-DFZHHIFOAV;
	SMILES [Li+].[Li+].[Li+].O=C([O-])CC(O)(C([O-])=O)CC(=O)[O-];
Properties
Chemical formula	Li3C6H5O7
Molar mass	209.923 g mol−1
Appearance	Odorless white powder
Melting point	decomposes at 105 °C (221 °F; 378 K)
Hazards
	GHS labelling:
Pictograms
Signal word	Warning
Hazard statements	H302, H319
Precautionary statements	P305+P351+P338
Flash point	N/A
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). verify (what is ?) Infobox references

Lithium citrate (Li₃C₆H₅O₇) is a lithium salt of citric acid that is used as a mood stabilizer in psychiatric treatment of manic states and bipolar disorder.^[1]^[2]^[3]^[4] There is extensive pharmacology of lithium, the active component of this salt.

Lithia water contains various lithium salts, including the citrate.

History

An early version of Coca-Cola available in pharmacies' soda fountains called Lithia Coke was a mixture of Coca-Cola syrup and lithia water. The soft drink 7Up was originally named "Bib-Label Lithiated Lemon-Lime Soda" when it was formulated in 1929 because it contained lithium citrate. The beverage was a patent medicine marketed as a cure for hangover. Lithium citrate was removed from 7Up in 1948^[5] after the Food and Drug Administration banned its use in soda.^[6]

Lithium citrate is used as a mood stabilizer and is used to treat mania, hypomania, depression and bipolar disorder.^[7] It can be administered orally in the form of a syrup.^[7]

References

^ Medication description
^ "pms-Lithium Citrate - Uses, Side Effects, Interactions - MedBroadcast.com". medbroadcast.com. Retrieved 2017-08-15.
^ "Medical use". Archived from the original on 2006-06-15. Retrieved 2006-07-29.
^ "Lithium: medicine to control mood disorders such as mania and bipolar disorder". nhs.uk. 2020-08-17. Retrieved 2022-08-25.
^ Gielen, Marcel; Edward R. T. Tiekink (2005). Metallotherapeutic drugs and metal-based diagnostic agents: The use of metals in medicine. John Wiley and Sons. p. 3. ISBN 0-470-86403-6.
^ "Here's the Gross Thing That Happens when You Mix 7-Up with Lithium". 20 February 2016.
^ ^a ^b PubChem. "Lithium citrate". pubchem.ncbi.nlm.nih.gov. Retrieved 2022-09-08.

This drug article relating to the nervous system is a stub. You can help Wikipedia by expanding it.

[1] Medication description

[2] "pms-Lithium Citrate - Uses, Side Effects, Interactions - MedBroadcast.com". medbroadcast.com. Retrieved 2017-08-15.

[3] "Medical use". Archived from the original on 2006-06-15. Retrieved 2006-07-29.

[4] "Lithium: medicine to control mood disorders such as mania and bipolar disorder". nhs.uk. 2020-08-17. Retrieved 2022-08-25.

[gielen_3-5] Gielen, Marcel; Edward R. T. Tiekink (2005). Metallotherapeutic drugs and metal-based diagnostic agents: The use of metals in medicine. John Wiley and Sons. p. 3. ISBN 0-470-86403-6.

[6] "Here's the Gross Thing That Happens when You Mix 7-Up with Lithium". 20 February 2016.

[:0-7] PubChem. "Lithium citrate". pubchem.ncbi.nlm.nih.gov. Retrieved 2022-09-08.

[1]

Names

Other names Trilithium citrate trilithium 2-hydroxypropane-1,2,3-tricarboxylate
Identifiers
CAS Number	919-16-4^Y
3D model (JSmol)	Interactive image
ChEBI	CHEBI:64735
ChEMBL	ChEMBL1201170^Y
ChemSpider	12932^Y
DrugBank	DB14507
ECHA InfoCard	100.011.860
EC Number	213-045-8
PubChem CID	13520
RTECS number	TZ8616000
UNII	3655633623^Y
CompTox Dashboard (EPA)	DTXSID70883185
InChI InChI=1S/C6H8O7.3Li/c7-3(8)1-6(13,5(11)12)2-4(9)10;;;/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12);;;/q;3+1/p-3^Y Key: WJSIUCDMWSDDCE-UHFFFAOYSA-K^Y InChI=1/C6H8O7.3Li/c7-3(8)1-6(13,5(11)12)2-4(9)10;;;/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12);;;/q;3+1/p-3 Key: WJSIUCDMWSDDCE-DFZHHIFOAV
SMILES [Li+].[Li+].[Li+].O=C([O-])CC(O)(C([O-])=O)CC(=O)[O-]
Properties
Chemical formula	Li₃C₆H₅O₇
Molar mass	209.923 g mol⁻¹
Appearance	Odorless white powder
Melting point	decomposes at 105 °C (221 °F; 378 K)
Hazards
GHS labelling:
Pictograms
Signal word	Warning
Hazard statements	H302, H319
Precautionary statements	P305+P351+P338
Flash point	N/A
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). N verify (what is ^YN ?) Infobox references