Wikipedia

John Oghalai

John Oghalai (born December 14, 1968)[citation needed] is an American physician and scientist. He is the Leon J. Tiber and David S. Alpert Chair in Medicine at the University of Southern California Keck School of Medicine and chair of the USC Caruso Department of Otolaryngology.[1][2] Oghalai is an otolaryngologist.[3] His research focuses on anatomical[4] and molecular mechanisms in hearing and in ear and hearing disorders.[5][6]

John Oghalai
Born(1968-12-14)December 14, 1968
Wisconsin
Alma materUniversity of Wisconsin–Madison
Scientific career
FieldsOtorhinolaryngology
InstitutionsBaylor College of Medicine

Stanford University School of Medicine

Keck School of Medicine of USC

Early life and education

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Oghalai grew up in Madison (Wisconsin) with his father Rahim, mother Karen (née Herbert), and brother Mark, who also became a doctor.[7][8][9] Oghalai went to a Madison High School and became an Eagle Scout in 1983.[7][10] He received a Bachelor of Science degree in electrical engineering in 1990, and his medical degree in 1994, both at the University of Wisconsin at Madison.[11]

Career

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In 2003, Oghalai joined the faculty at the Baylor College of Medicine as an assistant professor.[12][13] He served as director at The Hearing Center at Texas Children's Hospital in Houston, TX in 2005.[14] He became an associate professor at Baylor in 2009.[15][13]

In 2010, Oghalai moved to Stanford University School of Medicine as an associate professor and became a full professor in 2015.[6][13] He became professor of otolaryngology and director of the Children’s Hearing Center at Stanford’s Lucile Packard Children's Hospital in 2016.[4]

In 2017, Oghalai moved to University of Southern California[16] to become chair of the Caruso Department of Otolaryngology at the Keck School of Medicine.[17]

As an otolaryngology clinician, Oghalai has treated patients with issues that include noise-induced hearing loss,[4] benign paroxysmal positional vertigo (BPPV),[3] Bell’s palsy and Ramsay Hunt Syndrome.[18] In addition, Oghalai treated rare diseases such as cholesteatoma.[19][20][21]

Research

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In a 2000 study, Oghalai and colleagues examined incidence of benign paroxysmal positional vertigo (BPPV) in geriatric patients at a Houston hospital. They found that 9% of the sample population had undiagnosed BPPV,[3] a predictor of fall risk, depression, and difficulties with daily activities.[22][23]

To help understand mechanisms of hearing loss brought on by explosive pressures such as those soldiers experience when exposed to roadside bombs, in 2013 Oghalai and his team studied blast effects on hearing in mice. They found that the main traumatic damage leading to noise-induced hearing loss was to cochlear hair and nerve cells,[24] the cells responsible for translating pressure waves into the nerve signals in hearing.[6][25]

In 2018, Oghalai and colleagues studied molecular dimensions of noise-induced hearing loss in mice by using optical coherence tomography, an imaging technique that allows in vivo (instead of invasive) observation and measurement. They found that after blasts damage hair cells, there is also a build up of ionized potassium in cochlear fluid.[5] The findings showed how high concentrations of potassium disrupts hair and nerve cells, whose degeneration or synaptopathy contributes to hearing loss.[26][27][28]

In 2022 Oghalai and colleagues published results for a longitudinal study on the effects of cochlear implants on deaf children with developmental delays. They compared cohorts of children who received the implants to a cohort of children who, due to insurance protocols, were only given hearing aids. The children who received implants showed improved cognitive and behavioral functioning.[29][30] [31]

Personal life

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John Oghalai is married to Tracy Nguyen-Oghalai, a rheumatologist. They have two sons, Kevin[32] and Tom.[2]

Selected publications

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  • Oghalai, JS; Manolidis, S; Barth, JL; Stewart, MG; Jenkins, HA (2000). "Unrecognized Benign Paroxysmal Positional Vertigo in Elderly Patients". Otolaryngology–Head and Neck Surgery. 122 (5): 630–634. doi:10.1016/S0194-5998(00)70187-2. PMID 10793337. S2CID 33401924.
  • Oghalai, JS; Zhao, HB; Kutz, JW; Brownell, WE (2000). "Voltage- and tension-dependent lipid mobility in the outer hair cell plasma membrane". Science. 287 (5453): 658–61. doi:10.1126/science.287.5453.658. PMC 1976274. PMID 10650000.
  • Chai, R; Wang, T; Liaw, EJ; Xia, A; Jan, TA; Liu, Z; Taketo, MM; Oghalai, JS; Nusse, R; Zuo, J; Cheng, AG (22 May 2012). "Wnt signaling induces proliferation of sensory precursors in the postnatal mouse cochlea". Proc Natl Acad Sci U S A. 109 (22): 8167–72. doi:10.1073/pnas.1202774109. PMC 3361451. PMID 22562792.
  • Lee, HY; Raphael, PD; Park, J; Ellerbee, AK; Applegate, BE; Oghalai, JS (10 March 2015). "Noninvasive in vivo imaging reveals differences between tectorial membrane and basilar membrane traveling waves in the mouse cochlea". Proc Natl Acad Sci U S A. 112 (10): 3128–33. doi:10.1073/pnas.1500038112. PMC 4364183. PMID 25737536.

References

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  1. ^ "John S. Oghalai, MD". USC Health Sciences Profiles. University of Southern California. Retrieved 19 January 2023.
  2. ^ a b "John S. Oghalai to lead otolaryngology". HSC News. University of Southern California. Retrieved 19 January 2023.
  3. ^ a b c Span, Paula (26 February 2016). "An Easy Fix for Vertigo". New York Times. Retrieved 13 January 2023.
  4. ^ a b c Oksman, Olga (31 August 2016). "NYC subway exposes commuters to noise as loud as a jet engine". Guardian. Retrieved 13 January 2023.
  5. ^ a b Wallis, Claudia (1 August 2018). "Ba-Boom! There Goes Your Hearing". Scientific American. Retrieved 13 January 2023.
  6. ^ a b c Fulton, Robert (28 July 2013). "Some Hearing Loss Can Be Reversed, New Study Finds". Men's Journal. Retrieved 13 January 2023.
  7. ^ a b "Masons cite scholars". Wisconsin State Journal. 17 May 1986.
  8. ^ "Obituary - Maxwell Herbert". Detroit Free Press, p. 21. 21 May 1995.
  9. ^ "Engagements - Williams/Oghalai". Wisconsin State Journal. 5 August 2001.
  10. ^ "Three Boy Scouts get Eagle Awards Eagle Awards". Wisconsin State Journal. 29 March 1983.
  11. ^ "Graduation: Bioengeneering". Rice University General Announcements. 2006/07: 103. 2006. Retrieved 30 March 2023.
  12. ^ Sharos, David (28 January 2006). "Volume of hearing loss rising". Chicago Tribune. Retrieved 13 January 2023.
  13. ^ a b c "Faculty: John S. Oghalai". keck.usc.edu. University of Southern California. Retrieved 28 February 2023.
  14. ^ Irvine, Martha (23 September 2005). "What's that?; Experts say increased headphone use exacerbates hearing loss in youth". The Record (Kitchener, Ont.).
  15. ^ Beam, Christopher (21 March 2007). "Can You Hear Without Ears? Can you smell without a nose?". Slate. Retrieved 13 January 2023.
  16. ^ Strickland, Anais (30 April 2017). "Appointments, Resignations, Deaths". The Chronicle of Higher Education. Retrieved 12 January 2023.
  17. ^ Becker, Rachel (16 September 2017). "Weaponizing sound: could sonic devices have injured diplomats in Cuba?". Verge. Retrieved 13 January 2023.
  18. ^ Mier, Tomás (10 June 2022). "Justin Bieber's Facial Paralysis Could Take 'Months' to Heal, Experts Say". Rolling Stone. Retrieved 13 January 2023.
  19. ^ Kuo CL, Lien CF, Shiao AS (2014). "Mastoid obliteration for pediatric suppurative cholesteatoma: long-term safety and sustained effectiveness after 30 years' experience with cartilage obliteration". Audiol Neurootol. 19 (6): 358–69. doi:10.1159/000363685. PMID 25377728. S2CID 30283836.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  20. ^ Egilmez OK, Hanege FM, Kalcioglu MT, Kaner T, Kokten N (2014). "Tegmen tympani defect and brain herniation secondary to mastoid surgery: case presentation". Case Rep Otolaryngol. 2014: 756280. doi:10.1155/2014/756280. PMC 4129166. PMID 25140266.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  21. ^ McMurphy AB, Oghalai JS (2005). "Repair of iatrogenic temporal lobe encephalocele after canal wall down mastoidectomy in the presence of active cholesteatoma". Otol Neurotol. 26 (4): 587–94. doi:10.1097/01.mao.0000178119.46290.e1. PMID 16015151. S2CID 37589021.
  22. ^ Laurent, G; Vereeck, L; Verbecque, E; Herssens, N; Casters, L; Spildooren, J (2022). "Effect of age on treatment outcomes in benign paroxysmal positional vertigo: A systematic review". Journal of the American Geriatrics Society. 70 (1): 281–293. doi:10.1111/jgs.17485. hdl:1942/35743. PMID 34698378. S2CID 239888032.
  23. ^ Oghalai, JS; Manolidis, S; Barth, JL; Stewart, MG; Jenkins, HA (2000). "Unrecognized Benign Paroxysmal Positional Vertigo in Elderly Patients". Otolaryngology–Head and Neck Surgery. 122 (5): 630–634. doi:10.1016/S0194-5998(00)70187-2. PMID 10793337. S2CID 33401924.
  24. ^ Kindt, Katie S; Sheets, Lavinia (2018). "Transmission Disrupted: Modeling Auditory Synaptopathy in Zebrafish". Frontiers in Cell and Developmental Biology. 6: 114. doi:10.3389/fcell.2018.00114. PMC 6143809. PMID 30258843.
  25. ^ Cho, Sung-Il; Simon, S. Gao; Xia, Anping; Wang, Rosalie; Salles, Felipe T.; Raphael, Patrick D.; Abaya, Homer; Wachte, Jacqueline; Baek, Jongmin; Jacobs, David; Rasband, Matthew N.; Oghalai, John S. (1 July 2013). "Mechanisms of hearing loss after blast injury to the ear". PLOS ONE. 8 (7): e67618. doi:10.1371/journal.pone.0067618. PMC 3698122. PMID 23840874.
  26. ^ Zhao, H; Zhu, Y; Liu, L (2021). "Excess extracellular K+ causes inner hair cell ribbon synapse degeneration". Communications Biology. 4 (1): 24. doi:10.1038/s42003-020-01532-w. PMC 7782724. PMID 33398038.
  27. ^ Houser, Kristin (14 May 2018). "An Injection Of Salt In Your Eardrum Might Save You From A Lifetime Of Hearing Loss". Futurism. Retrieved 13 January 2023.
  28. ^ Kim, J; Xia, A; Grillet, N; Applegate, B.E.; Oghalai, J.S. (2018). "Osmotic stabilization prevents cochlear synaptopathy after blast trauma". Proceedings of the National Academy of Sciences. 115 (21): E4853–E4860. doi:10.1073/pnas.1720121115. PMC 6003510. PMID 29735658.
  29. ^ Black, Lisa (24 May 2022). "Study Finds Benefits for Deaf Children With Developmental Delays Who Receive Cochlear Implants". AAP News. American Academy of Pediatrics. Retrieved 23 January 2023.
  30. ^ Katie, Hobbins (25 May 2022). "Cochlear implants benefit children with hearing loss and developmental delays, says study". Contemporary Pediatrics. Retrieved 18 January 2023.
  31. ^ Oghalai, JS; Bortfeld, H; Feldman, HM; Chimalakonda, N; Emery, C; Choi, JS; Zhou, S (2022). "Cochlear implants for deaf children with early developmental impairment". Pediatrics. 149 (6). doi:10.1542/peds.2021-055459. PMC 9648123. PMID 35607935.
  32. ^ Dong, Jocelyn (23 March 2013). "Small wonders: using books, front yards to foster neighborliness". Palo Alto Weekly. Retrieved 19 January 2023.
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