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Aaron I. Vinik was a South African and American physician-scientist who contributed immensely to the studies of clinical neuropathy and neuroendocrine tumors (NETS).[1] He is credited with having discovered both the INGAP gene responsible for stimulating immature cells in the diabetic pancreas to produce insulin and the chemical substance ilotropin.[2][3] For his pioneering work, Vinik earned the American College of Endocrinology (AACE) Distinction in Endocrinology Award and was honored with a professorship in his name at Eastern Virginia Medical School.[4][5]
Early life and education
editAaron Israel Vinik was born in 1937 in Van Ryan, in the Transvaal, South Africa. Vinik's parents were Ashkenazi Jewish immigrants from Lithuania ("Litvaks") who fled the antisemitic sociopolitical climate of Eastern Europe. In South Africa, the Vinik family became shopkeepers, and whilst in the town of Benoni, Aaron excelled in academics and sports. Encouraged to pursue education, he entered medical school at the University of the Witwatersrand in Johannesburg in 1955 where he proved a skilled football and pinball player. Vinik courted literature student Etta Fram and they wed in December of 1959.[6]
Career
editVinik concluded his chief residency at Chris Hani Baragwanath Hospital in Johannesburg, and began his research in the treatment of patients with hyperthyroidism in the Department of Endocrinology, Metabolism and Diabetes at the University of Cape Town. The focus of his doctoral thesis was the study of fatty acid metabolism in individuals with hyperthyroidism.[7] Vinik would then hold a position as a Senior Lecturer in Chemical Pathology, and in collaboration with Septimus Matthys Joubert, studied the role of human growth hormone in clinical disease and diabetes.[8]
During a visiting fellowship at at the University of California in San Francisco, Vinik studied chorionic somatomammotropin.[9] A brief return to South Africa would see prodigious scholarly output on the physiology of enteroendocrine hormones and diabetics with pancreaitis before he began his permanent residence in the United States as a Professor of Internal Medicine and Surgery at the University of Michigan, where his work therein apprised clinicians of treating patients with somatostatin analogues.[10]
The most consequential product of Vinik's career came in 1996, when, under his direction, scientists at the Strelitz Diabetes Center at Eastern Virginia discovered a gene they termed INGAP (Islet Neogenesis Associated Protein).[11] Developments in medical research have identified the potential of this gene for therapies and a possible cure for diabetes.[12][13]
Vinik holds numerous patents, among these being his creation of NutriNerve, a natural supplement that helps the body repair itself on a cellular level. [14][15]
Personal Life
editAaron Vinik and his wife Etta remained married for 64 years, until his death.[16] The union bore three sons, and his wife was often an indispensable partner to his extensive work, including in the development of a Quality of Life fatigue tool.[17] Of Aaron Vinik's sons are Howard Vinik, a businessman, Bryan S. Vinik an endocrinologist who specializes in the treatment of diabetes and metabolic disorders, and Steven Vinik, a wealth management executive.[18][19]
References
edit- ^ "Aaron I. Vinik, MD, PhD, FCP, MACP Eastern Virginia Medical School Director of Research and Neuroendocrine Unit, Murray Waitzer Endowed Chair for Diabetes Research at the EVMS Strelitz Diabetes Center". https://nanets.net/. North American Neuroendocrine Tumor Society. Retrieved December 13, 2024.
{{cite web}}: External link in|website= - ^ Lieb, David; Parson, Henri; Casellini, Carolina; Siraj, Elias (December 2023). "In Memoriam: Aaron I. Vinik, MD, PhD (1937 – 2023): The Quintessential Physician Scientist and Leader in Diabetic Neuropathy and Neuroendocrine Tumors". Endocrine Practice. 29 (12): 931. doi:10.1016/j.eprac.2023.11.003. Retrieved December 13, 2024.
- ^ Strelitz Diabetes Institutes. "Aaron I. Vinik, MD, PhD, FCP, FACP". ASNDI.ORG. Association of Diabetes Investigators. Retrieved December 13, 2024.
- ^ "In Memoriam: Aaron I. Vinik, MD, PhD, FCP, MACP, FACE". American Association of Clinical Endocrinology. Retrieved December 13, 2024.
- ^ EVMS News (19 April 2022). "New endowed professorship honors Dr. Aaron Vinik". Pulse Newsroom - Eastern Virginia Medical School. Eastern Virginia Medical School. Retrieved December 13, 2024.
- ^ Auerbach, Geraldine. "Aaron (Arthur) Vinik Endocrinologist/Clinician Neuroscientist Scholar/Author/ Educator" (PDF). JewishGen KehilaLinks. JewishGen. Retrieved December 13, 2024.
- ^ Vinik, Aaron (February 1970). "Studies on raised free fatty acids in hyperthyroidism". Metabolism. 19 (2): 93–101. doi:10.1016/S0026-0495(70)90158-7. PMID 5410945.
- ^ Vinik, A.I.; Joffe, B.I.; Joubert, S.M.; Jackson, W.P.U. (1 July 1970). "Growth hormone response to insulin-induced hypoglycemia in diabetes secondary to chronic calcific pancreatitis". The Journal of Clinical Endocrinology & Metabolism. 31 (1): 86–88. doi:10.1210/jcem-31-1-86. PMID 5425053.
- ^ Vinik, A.I.; Kaplan, S.L.; Grumbach, M.M. (3 April 1973). "Purification, Characterization and Comparison of Immunological Properties of Monkey Chorionic Somatomammotropin with Human and Monkey Growth Hormone, Human Chorionic Somatomammotropin and Ovine Prolactin". Endocrinology. 92 (4): 1051––1064. doi:10.1210/endo-92-4-1051. PMID 4631305.
- ^ Botha, J.L.; Vinik, A.I.; Child, P.; Lund, A.; van Tonder, S. (1977 Dec 10). "The effect of somatostatin on epinephrine induced free fatty acid release in normal man". South African Medical Journal. 52 (25): 995–997. PMID 607511.
{{cite journal}}: Check date values in:|date=(help) - ^ Knight-Ridder News Service (May 4, 1997). "Virginia researchers report isolating gene that spurs production of insulin Discovery could help in treatment of diabetes". Baltimore Sun. Retrieved December 13, 2024.
- ^ "Aaron I. Vinik MD, Ph.D. Director of research and neuroendocrine unit, Eastern Virginia Medical Schools Strelitz Diabetes Center". The Virginian Pilot. February 18, 2011. Retrieved December 13, 2024.
- ^ Nano, Eni; Rosenberg, Lawrence; Petropavlovskaia, Maria (June 2021). "Islet neogenesis associated protein (INGAP) protects pancreatic β cells from IL-1β and IFNγ-induced apoptosis". Cell Death Discovery. 7 (1): e96. doi:10.1038/s41420-021-00441-z. PMC 6898950. PMID 20587716.
- ^ "Aaron I. Vinik Inventions, Patents and Patent Applications". patents.justia. Justia. Retrieved 14 December 2024.
- ^ Chillemi, Stacey (21 July 2016). "NutriNerve: Breakthrough for Neuropathy". HuffPost. Retrieved 14 December 2024.
- ^ "Dr. Aaron Israel Vinik". Jewish News VA. Retrieved December 13, 2024.
- ^ Vinik, Etta; Vinik, Aaron; Paulson, James; Merkies, Ingemar; Packman, Jeff; Grogan, Donna; Coelho, Tessa (2014). "Norfolk QOL-DN: validation of a patient reported outcome measure in transthyretin familial amyloid polyneuropathy". Journal of the Peripheral Nervous System : JPNS. 19 (2). National Institutes of Health (NIH): 104–114. doi:10.1111/jns5.12059. PMID 24738700. Retrieved 14 December 2024.
- ^ Boca Raton Observer (December 23, 2022). "Castle Connolly Private Health Partners". Retrieved 14 December 2024.
- ^ Burroughes, Tom. "StanChart Investment Advisory Head In North Asia Leaves". WealthBriefing. Clearview Publishing. Retrieved 14 December 2024.