File:Human-ASPM-participates-in-spindle-organisation-spindle-orientation-and-cytokinesis-1471-2121-11-85-S6.ogv
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Human-ASPM-participates-in-spindle-organisation-spindle-orientation-and-cytokinesis-1471-2121-11-85-S6.ogv (Ogg Theora video file, length 18 s, 332 × 331 pixels, 1.22 Mbps, file size: 2.62 MB)
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[edit]DescriptionHuman-ASPM-participates-in-spindle-organisation-spindle-orientation-and-cytokinesis-1471-2121-11-85-S6.ogv |
English: Asymmetrical division and cytokinesis failure in a siRNA mediated ASPM depleted U2OS cell. A U2OS cell treated with ASP1 siRNA undergoing an asymmetric division with the mitotic spindle perpendicular to the surface of the imaging dish. This results in one daughter being extruded vertically from the dividing cell, towards the observer, while the other remains attached to the substrate. In this example cytokinesis fails, resulting in the formation of a binucleate cell. |
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Date | |||
Source | Higgins J, Midgley C, Bergh A, Bell S, Askham J, Roberts E, Binns R, Sharif S, Bennett C, Glover D, Woods C, Morrison E, Bond J (2010). "Human ASPM participates in spindle organisation, spindle orientation and cytokinesis". BMC Cell Biology. DOI:10.1186/1471-2121-11-85. PMID 21044324. PMC: 2988714. | ||
Author | Higgins J, Midgley C, Bergh A, Bell S, Askham J, Roberts E, Binns R, Sharif S, Bennett C, Glover D, Woods C, Morrison E, Bond J | ||
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This file is licensed under the Creative Commons Attribution 2.0 Generic license.
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Date/Time | Thumbnail | Dimensions | User | Comment | |
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current | 01:53, 21 November 2012 | 18 s, 332 × 331 (2.62 MB) | Open Access Media Importer Bot (talk | contribs) | Automatically uploaded media file from Open Access source. Please report problems or suggestions here. |
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Short title | Additional file 6 |
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Author | Higgins J, Midgley C, Bergh A, Bell S, Askham J, Roberts E, Binns R, Sharif S, Bennett C, Glover D, Woods C, Morrison E, Bond J |
Usage terms | http://creativecommons.org/licenses/by/2.0/ |
Image title | Asymmetrical division and cytokinesis failure in a siRNA mediated ASPM depleted U2OS cell. A U2OS cell treated with ASP1 siRNA undergoing an asymmetric division with the mitotic spindle perpendicular to the surface of the imaging dish. This results in one daughter being extruded vertically from the dividing cell, towards the observer, while the other remains attached to the substrate. In this example cytokinesis fails, resulting in the formation of a binucleate cell. |
Software used | Xiph.Org libtheora 1.1 20090822 (Thusnelda) |
Date and time of digitizing | 2010 |