DDX59

DDX59
Dostupne strukture
PDB	Pretraga ortologa: PDBe RCSB
Spisak PDB ID kodova
	2YQP
Identifikatori
Aliasi	DDX59
Vanjski ID-jevi	OMIM: 615464 MGI: 1915247 HomoloGene: 12222 GeneCards: DDX59
Lokacija gena (čovjek)
Hrom.	Hromosom 1 (čovjek)
Kraj	200,669,907 bp
Lokacija gena (miš)
Hrom.	Hromosom 1 (miš)
Kraj	136,367,896 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• nucleotide binding; • hydrolase activity; • ATP binding; • GO:0008026 helicase activity; • vezivanje iona metala; • vezivanje sa RNK; • nucleic acid binding;
Ćelijska komponenta	• intracellular anatomical structure; • jedro; • Jedarce; • citoplazma; • membrana; • integral component of membrane;
Biološki proces	• RNA secondary structure unwinding;
	Izvori:Amigo / QuickGO
Ortolozi
	83479
	67997
	ENSG00000118197
	ENSMUSG00000026404
	Q5T1V6; Q5T1W1
	Q9DBN9
NM_001031725; NM_031306; NM_001320181; NM_001320182; NM_001349799;
	NM_001349800; NM_001349801; NM_001349802; NM_001349803; NM_001349804
	NM_026500; NM_178052
NP_001026895; NP_001307110; NP_001307111; NP_001336728; NP_001336729;
	NP_001336730; NP_001336731; NP_001336732; NP_001336733
	NP_080776
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Vjerovatno ATP-ovisna RNK-helikaza DDX59 jest enzim koji je kod ljudi kodiran genom DDX59 sa hromosoma 1.^[5]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 619 aminokiselina, a molekulska težina 68.810 Da.^[6]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MFVPRSLKIK	RNANDDGKSC	VAKIIKPDPE	DLQLDKSRDV	PVDAVATEAA
TIDRHISESC	PFPSPGGQLA	EVHSVSPEQG	AKDSHPSEEP	VKSFSKTQRW
AEPGEPICVV	CGRYGEYICD	KTDEDVCSLE	CKAKHLLQVK	EKEEKSKLSN
PQKADSEPES	PLNASYVYKE	HPFILNLQED	QIENLKQQLG	ILVQGQEVTR
PIIDFEHCSL	PEVLNHNLKK	SGYEVPTPIQ	MQMIPVGLLG	RDILASADTG
SGKTAAFLLP	VIMRALFESK	TPSALILTPT	RELAIQIERQ	AKELMSGLPR
MKTVLLVGGL	PLPPQLYRLQ	QHVKVIIATP	GRLLDIIKQS	SVELCGVKIV
VVDEADTMLK	MGFQQQVLDI	LENIPNDCQT	ILVSATIPTS	IEQLASQLLH
NPVRIITGEK	NLPCANVRQI	ILWVEDPAKK	KKLFEILNDK	KLFKPPVLVF
VDCKLGADLL	SEAVQKITGL	KSISIHSEKS	QIERKNILKG	LLEGDYEVVV
STGVLGRGLD	LISVRLVVNF	DMPSSMDEYV	HQIGRVGRLG	QNGTAITFIN
NNSKRLFWDI	AKRVKPTGSI	LPPQLLNSPY	LHDQKRKEQQ	KDKQTQNDLV
TGANLMDIIR	KHDKSNSQK

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000118197 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000026404 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: DDX59 DEAD (Asp-Glu-Ala-Asp) box polypeptide 59".
^ "UniProt, Q5T1V6" (jezik: en.). Pristupljeno 9. 12. 2021.CS1 održavanje: nepoznati jezik (link)

Dopunska literatura

Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.

Vanjski linkovi

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000118197 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000026404 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: DDX59 DEAD (Asp-Glu-Ala-Asp) box polypeptide 59".

[UniProt-6] "UniProt, Q5T1V6" (jezik: en.). Pristupljeno 9. 12. 2021.CS1 održavanje: nepoznati jezik (link)

[1]

p r u Enzimi
Teme	Aktivno mjesto Alosterna regulacija Difuzijski limitirani enzim EC broj Enzimska kataliza Inhibicija enzimskih reakcija Kinetika enzima Koenzim Kooperativnost Lineweaver–Burkov dijagram Michaelis–Mentenova kinetika Mjesto vezanja Spisak enzima
Tipovi	EC1 Oksidoreduktaze/spisak EC2 Transferaze/spisak EC3 Hidrolaze/spisak EC4 Lijaze/spisak EC5 Izomeraze/spisak EC6 Ligaze/spisak