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Puberty

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"Sexual development" redirects here. For sexual development of non-human organisms, see Sexual maturity.
For the painting by Edvard Munch, see Puberty (Munch).
"Pubescence" redirects here. For the 2011 Chinese film, see Pubescence (film).

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Puberty is the process of physical changes through which a child's body matures into an adult body capable of sexual reproduction. It is initiated by hormonal signals from the brain to the gonads: the ovaries in a female, the testicles in a male. In response to the signals, the gonads produce hormones that stimulate libido and the growth, function, and transformation of the brain, bones, muscle, blood, skin, hair, breasts, and sex organs. Physical growth—height and weight—accelerates in the first half of puberty and is completed when an adult body has been developed. Before puberty, the external sex organs, known as primary sexual characteristics, are sex characteristics that distinguish males and females. Puberty leads to sexual dimorphism through the development of the secondary sex characteristics, which further distinguish the sexes.

On average, females begin puberty at age 10½ and complete puberty at ages 15-17; males begin at ages 11½-12 and complete puberty at ages 16-17.[1][2][3] The major landmark of puberty for females is menarche, the onset of menstruation, which occurs on average around age 12½.[2] For males, first ejaculation, spermarche, occurs on average at age 13.[4] In the 21st century, the average age at which children, especially females, reach specific markers of puberty is lower compared to the 19th century, when it was 15 for females and 17 for males (with age at first periods for females and voice-breaks for males being used as examples).[5] This can be due to any number of factors, including improved nutrition resulting in rapid body growth, increased weight and fat deposition,[6] or exposure to endocrine disruptors such as xenoestrogens, which can at times be due to food consumption or other environmental factors.[7][8] However, more modern archeological research suggests that the rate of puberty as it occurs now is the intended way. Growth spurts began at around 10-12, but markers of later stages of puberty such as menarche had delays that correlated with severe environmental conditions such as poverty, poor nutrition, air and pollution.[9][10][11] Puberty that starts earlier than usual is known as precocious puberty, and puberty which starts later than usual is known as delayed puberty.

Notable among the morphologic changes in size, shape, composition, and functioning of the pubertal body, is the development of secondary sex characteristics, the "filling in" of the child's body; from girl to woman, from boy to man. Derived from the Latin puberatum (age of maturity), the word puberty describes the physical changes to sexual maturation, not the psychosocial and cultural maturation denoted by the term adolescent development in Western culture, wherein adolescence is the period of mental transition from childhood to adulthood, which overlaps much of the body's period of puberty.[12]

Differences between male and female puberty

Approximate outline of development periods from childhood to early adulthood. Puberty is marked in green at right.
Hormone feedback cycles:
1 Follicle-stimulating hormone – FSH
2 Luteinizing hormone – LH
3 Progesterone
4 Estrogen
5 Hypothalamus
6 Pituitary gland
7 Ovary
8 Pregnancy – hCG (Human chorionic gonadotropin)
9 Testosterone
10 Testicle
11 Incentives
12 Prolactin – PRL

Two of the most significant differences between puberty in females and puberty in males are the age at which it begins, and the major sex steroids involved, the androgens and the estrogens.

Although there is a wide range of normal ages, females typically begin the process of puberty around age 10½ and end puberty around 15–17; males begin around ages 11½—12 and end around 16–17.[1][2][3] Females attain reproductive maturity about four years after the first physical changes of puberty appear.[13] In contrast, males accelerate more slowly but continue to grow for about six years after the first visible pubertal changes.[14]

For males, the androgen testosterone is the principal sex hormone; while testosterone is produced, all males' changes are characterized as virilization. A substantial product of testosterone metabolism in males is the estrogen estradiol. The conversion of testosterone to estradiol depends on the amount of body fat and estradiol levels in males are typically much lower than in females. The male "growth spurt" also begins later, accelerates more slowly, and lasts longer before the epiphyses fuse. Although males are on average 2 centimetres (0.8 in) shorter than females before puberty begins, adult men are on average about 13 centimetres (5.1 in) taller than women. Most of this sex difference in adult heights is attributable to a later onset of the growth spurt and a slower progression to completion, a direct result of the later rise and lower adult male levels of estradiol.[15]

The hormonal maturation of females is considerably more complicated than in males. The main steroid hormones, testosterone, estradiol, and progesterone as well as prolactin play important physiological functions in puberty. The production of gonadal steroids in females starts with production of testosterone, which is typically quickly converted to estradiol inside the ovaries. However the rate of conversion from testosterone to estradiol (driven by FSH/LH balance) during early puberty is highly individual, resulting in very diverse development patterns of secondary sexual characteristics. Production of progesterone in the ovaries begins with the development of ovulatory cycles in females (during the lutheal phase of the cycle), before puberty low levels of progesterone are produced in the adrenal glands of both males and females. Estradiol levels rise earlier and reach higher levels in women than in men. While estradiol promotes growth of the breasts and uterus, it is also the principal hormone driving the pubertal growth spurt and epiphyseal maturation and closure.[16]

Puberty onset

Puberty is preceded by adrenarche, marking an increase of adrenal androgen production between ages 6–10. Adrenarche is sometimes accompanied by the early appearance of axillary and pubic hair. The first androgenic hair resulting from adrenarche can be also transient and disappear before the onset of true puberty.

The onset of puberty is associated with high GnRH pulsing, which precedes the rise in sex hormones, LH and FSH.[17] Exogenous GnRH pulses cause the onset of puberty.[18] Brain tumors which increase GnRH output may also lead to premature puberty.[19]

The cause of the GnRH rise is unknown. Leptin might be the cause of the GnRH rise. Leptin has receptors in the hypothalamus which synthesizes GnRH.[20] Individuals who are deficient in leptin fail to initiate puberty.[21] The levels of leptin increase with the onset of puberty, and then decline to adult levels when puberty is completed. The rise in GnRH might also be caused by genetics. A study discovered that a mutation in genes encoding both neurokinin B as well as the neurokinin B receptor can alter the timing of puberty.[22] The researchers hypothesized that neurokinin B might play a role in regulating the secretion of kisspeptin, a compound responsible for triggering direct release of GnRH as well as indirect release of LH and FSH.[22]

Effects of early and late puberty onset

Several studies about puberty have examined the effects of an early or a late onset of puberty in males and females. In general, females who enter puberty late experience positive outcomes in adolescence and adulthood, while females who enter puberty early experience negative outcomes. Males who have earlier pubertal timing generally have more positive outcomes in adulthood but more negative outcomes in adolescence, while the reverse is true for later pubertal timing.[23]

Females

Outcomes have generally indicated that early onset of puberty in females can be psychologically damaging. The main reason for this detrimental effect is the issue of body image. As they physically develop, gaining weight in several areas of the body, early-maturing females usually look larger than females who have not yet entered puberty. A result of the social pressure to be thin, the early-maturing females develop a negative view of their body image. In addition, people may tease the females about their visible breasts, forcing the early-maturing female to hide her breasts by dressing differently. Embarrassment about a more developed body may also result in the refusal to undress for gym. These experiences lead to lower self-esteem, more depression and poorer body image in these early-maturing females.[23]

Furthermore, as physical and emotional differences set them apart from people in their same age group, early-maturing females develop relationships with older people. For instance, some early-maturing females have older malefriends, "attracted to the females' womanly physique and femaleish innocence."[23] While having an older malefriend might improve popularity among peers, it also increases the risk of alcohol and drug use, increased sexual relations (often unprotected), eating disorders and bullying.[23]

Generally, later onset of puberty in females produces positive outcomes. They exhibit positive behaviors in adolescence that continue to adulthood.[23]

Males

In the past, early onset of puberty in males has been associated with positive outcomes, such as leadership in high school and success in adulthood.[24] However, recent studies have revealed that the risks and problems of early maturation in males might outweigh the benefits.[23]

Early-maturing males develop "more aggressive, law-breaking, and alcohol abusing" behaviors, which result in anger towards parents and trouble in school and with the police. Early puberty also correlates with increased sexual activity and a higher instance of teenage pregnancy, both of which can lead to depression and other psychosocial issues.[23]

On the other hand, late-maturing males develop lower self-esteem and confidence and generally have lower popularity among peers, due to their less-developed physiques. Also, they experience problems with anxiety and depression and are more likely to be afraid of sex than other males.[23]

Changes in males

See also: Tanner scale

In males, puberty begins with the enlargement of the testicles and scrotum. The penis also increases in size, and a male develops pubic hair. A male's testicles also begin making sperm. The release of semen, which contains sperm and other fluids, is called ejaculation.[25] During puberty, a male's erect penis becomes capable of ejaculating semen and impregnating a female.[26][27] A male's first ejaculation is an important milestone in his development.[28] On average, a male's first ejaculation occurs at age 13.[29] Ejaculation sometimes occurs during sleep; this phenomenon is known as a nocturnal emission.[25]

Testicular size

Five Tanner stages of male genitalia; The Adolescent Period

In males, testicular enlargement is the first physical manifestation of puberty (and is termed gonadarche).[30] Testes in prepubertal males change little in size from about 1 year of age to the onset of puberty, averaging about 2–3 cm in length and about 1.5–2 cm in width. The size of the testicles is among the parameters of the Tanner scale for male genitals, from stage I which represents a volume of less than 1.5 ml, to stage V which represents a testicular volume of greater than or equal to 20 ml. Testicular size reaches maximal adult size about 6 years after the onset of puberty. While 18–20 cm3 is an average adult size, there is wide variation in testicular size in the normal population.[31] After the male's testicles have enlarged and developed for about one year, the length and then the breadth of the shaft of the penis will increase and the glans penis and corpora cavernosa will also start to enlarge to adult proportions.[32]

Development of a male from childhood to the end of puberty

Erections

Erections during sleep or when waking up are medically known as nocturnal penile tumescence and colloquially referred to as morning wood.[33] The penis can regularly get erect during sleep and men or males often wake up with an erection.[34] Once a male reaches his teenage years, erections occur much more frequently due to puberty.[35] Erections can occur spontaneously at any time of day, and if clothed may cause a bulge or "hump". This can be disguised or hidden by wearing close-fitting underwear, a long shirt and baggier clothes.[36] Erections are common for male prepubescent children and infants, and can even occur before birth.[37] Spontaneous erections, also known as involuntary or unwanted erections, are normal. Such erections can be embarrassing if they happen in public, such as a classroom or living room.[38][39]

Foreskin retraction

During puberty, if not before, the tip and opening of a male's foreskin becomes wider, progressively allowing for retraction down the shaft of the penis and behind the glans, which ultimately should be possible without pain or difficulty. The membrane that bonds the inner surface of the foreskin with the glans disintegrates and releases the foreskin to separate from the glans. The foreskin then gradually becomes retractable.[40]

Research by Øster (1968) found that with the onset and continuation of puberty, the proportion of males able to pull back their foreskins increased. At ages 12–13, Øster found that only 60% of males were able to retract their foreskins; this increased to 85% by ages 14–15, and 95% by 16–17. He also found that 1% of those unable to fully retract experienced phimosis at ages 14–17, the remainder were partially able to.[40] The findings were supported by further research by Kayaba et al (1996) on a sample of over 600 males,[41] and Ishikawa and Kawakita (2004) found that by age 15, 77% of their sample of males could retract their foreskins.[42] Beaugé (1997) reports that males may assist the development of retractile foreskin by manual stretching.[43]

Once a male is able to retract his foreskin, penile hygiene should become an important feature of his routine body care. Although the American Academy of Pediatrics states there is "little evidence to affirm the association between circumcision status and optimal penile hygiene",[44] various studies suggest that males be educated about the role of hygiene, including retracting the foreskin while urinating and rinsing under it and around the glans at each bathing opportunity. Regular washing under the foreskin was found by Krueger and Osborn (1986) to reduce the risk of numerous penile disorders,[45] however Birley et al. (1993) reports excessive washing with soap should be avoided because it dries the oils out of the tissues and can cause non-specific dermatitis.[46]

Male at 11.3 yo (prepubertal), 12.5 yo, 14.9 yo and 16.3 yo (post pubertal)

Body and facial hair

Facial hair of a male

In the months and years following the appearance of pubic hair, other areas of skin that respond to androgens may develop androgenic hair. The usual sequence is: underarm (axillary) hair, perianal hair, upper lip hair, sideburn (preauricular) hair, periareolar hair, and the beard area.[47] As with most human biological processes, this specific order may vary among some individuals. Arm, leg, chest, abdominal, and back hair become heavier more gradually. There is a large range in amount of body hair among adult men, and significant differences in timing and quantity of hair growth among different racial groups. Facial hair is often present in late adolescence, but may not appear until significantly later.[48][49] Facial hair will continue to get coarser, darker and thicker for another 2–4 years after puberty.[48] Some men do not develop full facial hair for up to 10 years after the completion of puberty.[48]

Voice change and Adam's apple

Main articles: Voice change and Adam's apple
"Squeaky-voiced Teen" redirects here. For the The Simpsons character, see Squeaky-Voiced Teen.

Under the influence of androgens, the larynx (or voice box) grows in both sexes. This growth is far more prominent in males, causing the male voice to drop and deepen, sometimes abruptly but rarely "overnight", about one octave, because the longer and thicker vocal folds have a lower fundamental frequency. Before puberty, the larynx of males and females is about equally small.[50]

Changes in females

Tanner stages of puberty in females

Breast development

Main article: Breast development

The first physical sign of puberty in females is usually a firm, tender lump under the center of the areola of one or both breasts, occurring on average at about 10½ years of age.[51] This is referred to as thelarche. By the widely used Tanner staging of puberty, this is stage 2 of breast development (stage 1 is a flat, prepubertal breast). Within 6–12 months, the swelling has clearly begun in both sides, softened, and can be felt and seen extending beyond the edges of the areolae. This is stage 3 of breast development. By another 12 months (stage 4), the breasts are approaching mature size and shape, with areolae and nipples forming a secondary mound. In most young women, this mound disappears into the contour of the mature breast (stage 5), although there is so much variation in sizes and shapes of adult breasts that stages 4 and 5 are not always separately identifiable.[52]

Pubic hair

Pubic hair is often the second noticeable change in puberty, usually within a few months of thelarche.[53] It is referred to as pubarche. The pubic hairs are usually visible first along the labia. The first few hairs are described as Tanner stage 2.[52] Stage 3 is usually reached within another 6–12 months, when the hairs are too numerous to count and appear on the pubic mound as well. By stage 4, the pubic hairs densely fill the "pubic triangle". Stage 5 refers to spread of pubic hair to the thighs and sometimes as abdominal hair upward towards the navel. In about 15% of females, the earliest pubic hair appears before breast development begins.[53]

Vagina, uterus, ovaries

Perineal skin keratinizes due to effect of estrogen increasing its resistance to infection. The mucosal surface of the vagina also changes in response to increasing levels of estrogen, becoming thicker and duller pink in color (in contrast to the brighter red of the prepubertal vaginal mucosa).[54] Mucosa changes into a multilayered structure with superficial layer of squamous cells. Estrogen increase glycogen content in vaginal epithelium, which in future plays important part in maintaining vaginal pH. Whitish secretions (physiologic leukorrhea) are a normal effect of estrogen as well.[51] In the two years following thelarche, the uterus, ovaries, and the follicles in the ovaries increase in size.[55] The ovaries usually contain small follicular cysts visible by ultrasound.[56][57]

Menstruation and fertility

The first menstrual bleeding is referred to as menarche, and typically occurs about two years after thelarche.[53] The average age of menarche is 12½ in the United States.[58] Most American females experience their first period at 11, 12 or 13, but some experience it earlier than their 11th birthday and others after their 14th birthday. In fact, anytime between 8 and 16 is normal. In Canada, the average age of menarche is 12.72,[59] and in the United Kingdom it is 12.9.[60] The time between menstrual periods (menses) is not always regular in the first two years after menarche.[61] Ovulation is necessary for fertility, but may or may not accompany the earliest menses.[62] In postmenarchal females, about 80% of the cycles were anovulatory in the first year after menarche, 50% in the third year and 10% in the sixth year.[61] Initiation of ovulation after menarche is not inevitable. A high proportion of females with continued irregularity in the menstrual cycle several years from menarche will continue to have prolonged irregularity and anovulation, and are at higher risk for reduced fertility.[63]

Body shape, fat distribution, and body composition

Development of a female from childhood to the end of puberty

During this period, also in response to rising levels of estrogen, the lower half of the pelvis and thus hips widen (providing a larger birth canal).[52][64] Fat tissue increases to a greater percentage of the body composition than in males, especially in the typical female distribution of breasts, hips, buttocks, thighs, upper arms, and pubis. Progressive differences in fat distribution as well as sex differences in local skeletal growth contribute to the typical female body shape by the end of puberty. On average, at 10 years, females have 6% more body fat than males.[65]

Body odor and acne

Rising levels of androgens can change the fatty acid composition of perspiration, resulting in a more "adult" body odor. This often precedes thelarche and pubarche by one or more years. Another androgen effect is increased secretion of oil (sebum) from the skin. This change increases the susceptibility to acne, a skin condition that is characteristic of puberty. Acne varies greatly in its severity.[66]

Visual and other effects of hormonal changes

Testosterone will cause an enlargement of the clitoris and possibly has important effects on the growth and maturation of the vestibular bulbs, corpora cavernosa of the clitoris and urethral sponge.[67]

Changes of the vulva initiated by estradiol as well as its direct effects also appear to influence the functioning of the lower urinary tract.[68][69]

Underarm hair

Hair growth develops under the arms, starting out sparse before thickening and darkening over time.[70]

Variations

Variations of the initial and final height of three males from 12 years old to the end of their growth spurt

In a general sense, the conclusion of puberty is reproductive maturity. Criteria for defining the conclusion may differ for different purposes: attainment of the ability to reproduce, achievement of maximal adult height, maximal gonadal size, or adult sex hormone levels. Maximal adult height is achieved at an average age of 15 years for an average female and 18 years for an average male. Potential fertility (sometimes termed nubility) usually precedes completion of growth by 1–2 years in females and 3–4 years in males. Stage 5 typically represents maximal gonadal growth and adult hormone levels.[citation needed]

Age of onset

The definition of the onset of puberty may depend on perspective (e.g., hormonal versus physical) and purpose (establishing population normal standards, clinical care of early or late pubescent individuals, etc.). A common definition for the onset of puberty is physical changes to a person's body.[13] These physical changes are the first visible signs of neural, hormonal, and gonadal function changes.

The age at which puberty begins varies between individuals; usually, puberty begins between 10 and 13 years of age. The age at which puberty begins is affected by both genetic factors and by environmental factors such as nutritional state and social circumstances.[71] An example of social circumstances is the Vandenbergh effect; a juvenile female who has significant interaction with adult males will enter puberty earlier than juvenile females who are not socially overexposed to adult males.[72]

The average age at which puberty begins may be affected by ethnicity as well. For example, the average age of menarche in various populations surveyed has ranged from 12[58][59][60] to 18 years. The earliest average onset of puberty is for African-American females and the latest average onset for high altitude subsistence populations in Asia. However, much of the higher age averages reflect nutritional limitations more than genetic differences and can change within a few generations with a substantial change in diet. The median age of menarche for a population may be an index of the proportion of undernourished females in the population, and the width of the spread may reflect unevenness of wealth and food distribution in a population.

Researchers have identified an earlier age of the onset of puberty. However, they have based their conclusions on a comparison of data from 1999 with data from 1969. In the earlier example, the sample population was based on a small sample of white females (200, from Britain). The later study identified as puberty as occurring in 48% of African-American females by age nine, and 12% of white females by that age.[73]

One possible cause of a delay in the onset of puberty past the age 14 in females and 15 in males is Kallmann syndrome, a form of hypogonadotropic hypogonadism (HH). Kallmann syndrome is also associated with a lack of sense of smell (anosmia). Kallmann syndrome and other forms of HH affect both men and women. It is caused by a failure in HPG axis at puberty which results in low or zero gonadotropin (LH and FSH) levels with the subsequent result of a failure to commence or complete puberty, secondary hypogonadism and infertility.[74][75]

Comparison of two individual with vast difference in the age of onset of puberty:
Two males from 11.5 to 16.6 years old
Two females from 8.0 to 14.5 years old

Historical shift

The average age at which the onset of puberty occurs has dropped significantly since the 1840s.[76][77][78]

A 2006 study in Denmark found that puberty, as evidenced by breast development, started at an average age of 9 years and 10 months, a year earlier than when a similar study was done in 1991. Scientists believe the phenomenon could be linked to obesity or exposure to chemicals in the food chain, and is putting females at greater long-term risk of breast cancer.[79]

Genetic influence and environmental factors

Various studies have found direct genetic effects to account for at least 46% of the variation of timing of puberty in well-nourished populations.[80][81][82][83] The genetic association of timing is strongest between mothers and daughters. The specific genes affecting timing are not yet known.[80] Among the candidates is an androgen receptor gene.[84]

Researchers have hypothesized that early puberty onset may be caused by certain hair care products containing estrogen or placenta, and by certain chemicals, namely phthalates, which are used in many cosmetics, toys, and plastic food containers.[73]

Hormones and steroids

There is theoretical concern, and animal evidence, that environmental hormones and chemicals may affect aspects of prenatal or postnatal sexual development in humans.[85]

Bisphenol A (BPA) is a chemical used to make plastics, and is frequently used to make baby bottles, water bottles, sports equipment, medical devices, and as a coating in food and beverage cans. Scientists are concerned about BPA's behavioral effects on fetuses, infants, and children at current exposure levels because it can affect the prostate gland, mammary gland, and lead to early puberty in females. BPA mimics and interferes with the action of estrogen—an important reproduction and development regulator. It leaches out of plastic into liquids and foods, and the Centers for Disease Control and Prevention (CDC) found measurable amounts of BPA in the bodies of more than 90 percent of the U.S. population studied. The highest estimated daily intakes of BPA occur in infants and children. Many plastic baby bottles contain BPA, and BPA is more likely to leach out of plastic when its temperature is increased, as when one warms a baby bottle or warms up food in the microwave.[86]

Nutritional influence

Nutritional factors are the strongest and most obvious environmental factors affecting timing of puberty.[80]

Obesity influence and exercise

Scientific researchers have linked early obesity with an earlier onset of puberty in females. They have cited obesity as a cause of breast development before nine years and menarche before twelve years.[87] Early puberty in females can be a harbinger of later health problems.[88]

Physical and mental illness

Mental illnesses occur in puberty. The brain undergoes significant development by hormones which can contribute to mood disorders such as major depressive disorder, bipolar disorder, dysthymia and schizophrenia. Females aged between 15 and 19 make up 40% of anorexia nervosa cases.[89]

Neurohormonal process

The endocrine reproductive system consists of the hypothalamus, the pituitary, the gonads, and the adrenal glands, with input and regulation from many other body systems. True puberty is often termed "central puberty" because it begins as a process of the central nervous system. A simple description of hormonal puberty is as follows:

  1. The brain's hypothalamus begins to release pulses of GnRH.
  2. Cells in the anterior pituitary respond by secreting LH and FSH into the circulation.
  3. The ovaries or testes respond to the rising amounts of LH and FSH by growing and beginning to produce estradiol and testosterone.
  4. Rising levels of estradiol and testosterone produce the body changes of female and male puberty.

The onset of this neurohormonal process may precede the first visible body changes by 1–2 years.

Components of the endocrine reproductive system

The arcuate nucleus of the hypothalamus is the driver of the reproductive system. It has neurons which generate and release pulses of GnRH into the portal venous system of the pituitary gland. The arcuate nucleus is affected and controlled by neuronal input from other areas of the brain and hormonal input from the gonads, adipose tissue and a variety of other systems.

The pituitary gland responds to the pulsed GnRH signals by releasing LH and FSH into the blood of the general circulation, also in a pulsatile pattern.

The gonads (testes and ovaries) respond to rising levels of LH and FSH by producing the steroid sex hormones, testosterone and estrogen.

The adrenal glands are a second source for steroid hormones. Adrenal maturation, termed adrenarche, typically precedes gonadarche in mid-childhood.

Major hormones

Endocrine perspective

The endocrine reproductive system becomes functional by the end of the first trimester of fetal life. The testes and ovaries become briefly inactive around the time of birth but resume hormonal activity until several months after birth, when incompletely understood mechanisms in the brain begin to suppress the activity of the arcuate nucleus. This has been referred to as maturation of the prepubertal "gonadostat", which becomes sensitive to negative feedback by sex steroids. The period of hormonal activity until several months after birth, followed by suppression of activity, may correspond to the period of infant sexuality, followed by a latency stage, which Sigmund Freud described.[91]

Neurons of the arcuate nucleus secrete gonadotropin releasing hormone (GnRH) into the blood of the pituitary portal system. An American physiologist, Ernst Knobil, found that the GnRH signals from the hypothalamus induce pulsed secretion of LH (and to a lesser degree, FSH) at roughly 1–2 hour intervals. The LH pulses are the consequence of pulsatile GnRH secretion by the arcuate nucleus that, in turn, is the result of an oscillator or signal generator in the central nervous system ("GnRH pulse generator").[92] In the years preceding physical puberty, Robert M. Boyar discovered that the gonadotropin pulses occur only during sleep, but as puberty progresses they can be detected during the day.[93] By the end of puberty, there is little day-night difference in the amplitude and frequency of gonadotropin pulses.

Some investigators have attributed the onset of puberty to a resonance of oscillators in the brain.[94][95][96] By this mechanism, the gonadotropin pulses that occur primarily at night just before puberty represent beats.[97][98][99][100]

An array of "autoamplification processes" increases the production of all of the pubertal hormones of the hypothalamus, pituitary, and gonads.[101]

Hormone Units Prepubertal
Stage 1 		Stage 2 Stage 3 Stage 4 Stage 5
Phase
LHTooltip Luteinizing hormone mIU/mL 2.7 (<1.0–5.5) 4.2 (<1.0–9.0) 6.7 (<1.0–14.6) 7.7 (2.8–15.0) Follicular
Luteal 		7.6 (3–18)
6.6 (3–18)
U/L <0.1 (<0.1–0.2) 0.7 (<0.1–2.8) 2.1 (<0.1–6.8) 3.6 (0.9–8.1) Follicular
Luteal 		3.8 (1.6–8.1)
3.5 (1.5–8.0)
FSHTooltip Follicle-stimulating hormone mIU/mL 4.0 (<1–5) 4.6 (<1.0–7.2) 6.8 (3.3–10.5) 7.4 (3.3–10.5) Follicular
Luteal 		10.3 (6–15)
6.0 (3.4–8.6)
U/L 2.1 (<0.5–5.4) 3.5 (<0.5–6.6) 4.9 (0.7–9.0) 6.2 (1.1–11.3) Follicular
Luteal 		6.6 (1.9–10.8)
5.4 (1.8–10.5)
Estradiol pg/mL 9 (<9–20) 15 (<9–30) 27 (<9–60) 55 (16–85) Follicular
Luteal 		50 (30–100)
130 (70–300)
Estrone pg/mL 13 (<9–23) 18 (10–37) 26 (17–58) 36 (23–69) Follicular
Luteal 		44 (30–89)
75 (39–160)
Progesterone ng/dL 22 (<10–32) 30 (10–51) 36 (10–75) 175 (<10–2500) Follicular
Luteal 		35 (13–75)
    (200–2500)
Hydroxyprogesterone ng/dL 33 (<10–84) 52 (10–98) 75 (10–185) 97 (17–235) Follicular
Luteal 		48 (12–90)
178 (35–290)
DHEA-STooltip Dehydroepiandrosterone sulfate μg/dL 49a (20–95)
106b (40–200) 		129 (60–240) 155 (85–290) 195 (106–320) – 220 (118–320)
DHEATooltip Dehydroepiandrosterone ng/dL 35a (<10–70)
127b (72–180) 		297 (150–540) 328 (190–620) 394 (240–768) – 538 (215–855)
Androstenedione ng/dL 26 (<10–50) 77 (40–112) 126 (55–190) 147 (70–245) – 172 (74–284)
Testosterone ng/dL 10 (<10–22) 18 (<10–29) 26 (<10–40) 38 (24–62) – 40 (27–70)
Notes: Values are mean plasma levels, with ranges in parentheses. a = Pre-adrenarche. b = Post-adrenarche. (Adrenarche, or increased adrenal androgen section, occurs as a separate event and can precede puberty onset by 1 to 2 years.) Sources: [102]

Stages

  • adrenarche (approximately ages 6—8)
  • gonadarche (approximately age 10½ in females and age 11½ in males)
  • thelarche (approximately age 10½ in females)
  • pubarche (approximately age 11 in females and age 12 in males)
  • menarche (approximately age 12½ in females)
  • spermarche (approximately age 13½ in males[103])

See also

References

  1. ^ a b Kail RV, Cavanaugh JC (2010). Human Development: A Lifespan View (5th ed.). Cengage Learning. p. 296. ISBN 978-0-495-60037-4.
  2. ^ a b c Schuiling (2016). Women's Gynecologic Health. Jones & Bartlett Learning. p. 22. ISBN 978-1-284-12501-6. The changes that occur during puberty usually happen in an ordered sequence, beginning with thelarche (breast development) at around age 10 or 11, followed by adrenarche (growth of pubic hair due to androgen stimulation), peak height velocity, and finally menarche (the onset of menses), which usually occurs around age 12 or 13.
  3. ^ a b Phillips DC (2014). Encyclopedia of Educational Theory and Philosophy. SAGE Publications. pp. 18–19. ISBN 978-1-4833-6475-9. On average, the onset of puberty is about 18 months earlier for girls (usually starting around the age of 10 or 11 and lasting until they are 15 to 17) than for boys (who usually begin puberty at about the age of 11 to 12 and complete it by the age of 16 to 17, on average).
  4. ^ Scannapieco M, Connell-Carrick K (2005). Understanding Child Maltreatment: An Ecological and Developmental Perspective. Oxford University Press. p. 195. ISBN 978-0-19-803563-3.
  5. ^ Alleyne R (2010-06-13). "Girls now reaching puberty before 10—a year sooner than 20 years ago". The Daily Telegraph. London. Archived from the original on 2010-06-14.
  6. ^ Guillette EA, Conard C, Lares F, Aguilar MG, McLachlan J, Guillette LJ (March 2006). "Altered breast development in young girls from an agricultural environment". Environ. Health Perspect. 114 (3): 471–5. doi:10.1289/ehp.8280. PMC 1392245. PMID 16507474.
  7. ^ Buck Louis GM, Gray LE, Marcus M, Ojeda SR, Pescovitz OH, Witchel SF, et al. (February 2008). "Environmental factors and puberty timing: expert panel research needs". Pediatrics. 121 (Suppl 3): S192–207. doi:10.1542/peds.1813E. PMID 18245512.
  8. ^ Mouritsen A, Aksglaede L, Sørensen K, Mogensen SS, Leffers H, Main KM, et al. (April 2010). "Hypothesis: exposure to endocrine-disrupting chemicals may interfere with timing of puberty". Int. J. Androl. 33 (2): 346–59. doi:10.1111/j.1365-2605.2010.01051.x. PMID 20487042.
  9. ^ Lewis M (2020-07-13). "Children aren't starting puberty younger, medieval skeletons reveal". University of Reading.
  10. ^ Lewis M, Shapland F, Watts R (2016). "On the threshold of adulthood: A new approach for the use of maturation indicators to assess puberty in adolescents from medieval England" (PDF). American Journal of Human Biology. 28 (1): 48–56. doi:10.1002/ajhb.22761. PMID 26238500. S2CID 26111310.
  11. ^ Papadimitriou A (2016). "The Evolution of the Age at Menarche from Prehistorical to Modern Times". Journal of Pediatric and Adolescent Gynecology. 29 (6): 527–530. doi:10.1016/j.jpag.2015.12.002. PMID 26703478.
  12. ^ The Oxford Dictionary of English Etymology, C. T. Onions ed. Oxford University Press, 1996, p. 720.
  13. ^ a b "Puberty and adolescence". University of Maryland. Archived from the original on 2013-09-24. Retrieved 2013-09-13.
  14. ^ Garn, SM. Physical growth and development. In: Friedman SB, Fisher M, Schonberg SK., editors. Comprehensive Adolescent Health Care. St Louis: Quality Medical Publishing; 1992. Retrieved on 2009-02-20
  15. ^ Abbassi V (1998). "Growth and normal puberty". Pediatrics. 102 (2 Pt 3): 507–513. doi:10.1542/peds.102.S3.507. PMID 9685454. S2CID 24733669.
  16. ^ MacGillivray MH, Morishima A, Conte F, Grumbach M, Smith EP (1998). "Pediatric endocrinology update: an overview. The essential roles of estrogens in pubertal growth, epiphyseal fusion and bone turnover: lessons from mutations in the genes for aromatase and the estrogen receptor". Hormone Research. 49 (Suppl 1): 2–8. doi:10.1159/000053061. PMID 9554463. S2CID 72138474.
  17. ^ Plant TM (2001). "Leptin, growth hormone, and the onset of primate puberty". The Journal of Clinical Endocrinology and Metabolism. 86 (1): 458–460. doi:10.1210/jc.86.1.459. PMID 11232044.
  18. ^ Johnson M (2007-06-29). Essential Reproduction (6th Rev ed.). Blackwell Publishers.
  19. ^ "Precocious Puberty". MERCK. 2008-05-16.
  20. ^ Meister B, Håkansson ML (2001). "Leptin receptors in hypothalamus and circumventricular organs". Clinical and Experimental Pharmacology & Physiology. 28 (7): 610–617. doi:10.1046/j.1440-1681.2001.03493.x. PMID 11458889. S2CID 72146698.
  21. ^ Clayton PE, Trueman JA (2000). "Leptin and puberty". Archives of Disease in Childhood. 83 (1): 1–4. doi:10.1136/adc.83.1.1. PMC 1718397. PMID 10868988.
  22. ^ a b Topaloglu AK, Reimann F, Guclu M, Yalin AS, Kotan LD, Porter KM, et al. (2009). "TAC3 and TACR3 mutations in familial hypogonadotropic hypogonadism reveal a key role for Neurokinin B in the central control of reproduction". Nature Genetics. 41 (3): 354–358. doi:10.1038/ng.306. PMC 4312696. PMID 19079066.
  23. ^ a b c d e f g h Berger KS (2014). Invitation to the Life Span. New York: Worth Publishers. ISBN 978-1-4292-8352-6.
  24. ^ Taga KA (2006-05-03). "A Longitudinal Investigation of Associations Between Boys' Pubertal Timing and Adult Behavioral Health and Well-Being". Journal of Youth and Adolescence. 35 (3): 380–390. doi:10.1007/s10964-006-9039-4. S2CID 143325699.
  25. ^ a b "Puberty: Adolescent Male". Johns Hopkins Medicine. Retrieved 2020-02-27.
  26. ^ "Male Reproductive System Information". Cleveland Clinic.
  27. ^ "The Male Reproductive System". WebMD.
  28. ^ "Male puberty milestones". Health24. Retrieved 2020-02-27.
  29. ^ Jorgensen, Keiding & Skakkebaek 1991.
  30. ^ Styne (2002), p. 598.
  31. ^ Marshall & Tanner (1986), p. 180.
  32. ^ Jones, Kenneth W. (2006). Smith's Recognizable Patterns of Human Malformation. St. Louis, Mo: Elsevier Saunders. ISBN 978-0-7216-0615-6.
  33. ^ "h2g2 - The Morning Glory (or Nocturnal Penile Tumescence)". Archived from the original on 2016-03-07. Retrieved 2013-11-09.
  34. ^ Carroll J (2009-01-29). Sexuality Now: Embracing Diversity. Cengage Learning. ISBN 978-0-495-60274-3 – via Google Books.
  35. ^ Madaras L, Madaras A (2007-06-08). What's Happening to My Body? Book for Boys: Revised Edition. HarperCollins. ISBN 978-1-55704-769-4 – via Google Books.
  36. ^ Attwood S (2008-05-15). Making Sense of Sex: A Forthright Guide to Puberty, Sex and Relationships for People with Asperger's Syndrome. Jessica Kingsley Publishers. ISBN 978-1-84642-797-8 – via Google Books.
  37. ^ "Erections in Babies | LIVESTRONG.COM". Archived from the original on 2012-10-04. Retrieved 2012-01-07.
  38. ^ Madaras L, Madaras A (2007-06-08). What's Happening to My Body? Book for Boys: Revised Edition. HarperCollins. ISBN 978-1-55704-769-4 – via Google Books.
  39. ^ Madaras L, Madaras A (2007-06-06). What's Happening to My Body? Book for Girls: Revised Edition. HarperCollins. ISBN 978-1-55704-764-9 – via Google Books.
  40. ^ a b Øster J (April 1968). "Further Fate of the Foreskin: Incidence of Preputial Adhesions, Phimosis, and Smegma among Danish Schoolboys". Arch Dis Child. 43 (228): 200–202. doi:10.1136/adc.43.228.200. PMC 2019851. PMID 5689532.
  41. ^ Kayaba H, Tamura H, Kitajima S, Fujiwara Y, Kato T, Kato T (November 1996). "Analysis of Shape and Retractability of the Prepuce in 603 Japanese Boys". J Urol. 156 (5). American Urological Association, Inc.: 1813–1815. doi:10.1016/S0022-5347(01)65544-7. PMID 8863623.
  42. ^ Ishikawa E, Kawakita M (2004). "Preputial development in Japanese boys". Hinyokika Kiyo. 50 (5): 305–8. PMID 15237481.
  43. ^ Beaugé M (1997). "The causes of adolescent phimosis". Br J Sex Med (Sept/Oct): 26.
  44. ^ "Circumcision Policy Statement". Pediatrics. 103 (3): 686–93. 1999. doi:10.1542/peds.103.3.686. PMID 10049981.
  45. ^ Krueger H, Osborn L (1986). "Effects of hygiene among the uncircumcised". J Fam Pract. 22 (4): 353–5. PMID 3958682.
  46. ^ Birley HD, Luzzi GA, Bell R (1993). "Clinical features and management of recurrent balanitis: association with atopy and genital washing". Genitourin Med. 69 (5): 400–403. doi:10.1136/sti.69.5.400. PMC 1195128. PMID 8244363.
  47. ^ "Puberty -- Changes for Males". pamf.org. Retrieved 2009-02-20.
  48. ^ a b c "Getting The Facts: Puberty". ppwr. Archived from the original on 2008-01-04. Retrieved 2009-02-20.
  49. ^ "The No-Hair Scare". PBS. Archived from the original on 2009-02-05. Retrieved 2009-02-20.
  50. ^ "The structure of the larynx". Encyclopædia Britannica. Retrieved 2009-02-20.
  51. ^ a b Marshall & Tanner (1986), p. 187.
  52. ^ a b c Marshall & Tanner (1986), p. 188.
  53. ^ a b c Tanner JM, Davies PS (1985). "Clinical longitudinal standards for height and height velocity for North American children". The Journal of Pediatrics. 107 (3): 317–329. doi:10.1016/S0022-3476(85)80501-1. PMID 3875704.
  54. ^ Gordon & Laufer (2005), p. 151.
  55. ^ Marshall & Tanner (1986), pp. 186–187.
  56. ^ Rosenfield (2002), p. 462.
  57. ^ Siegel MJ, Surratt JT (1992). "Pediatric gynecologic imaging". Obstetrics and Gynecology Clinics of North America. 19 (1): 103–127. doi:10.1016/S0889-8545(21)00504-0. PMID 1584537.
  58. ^ a b Anderson SE, Dallal GE, Must A (April 2003). "Relative weight and race influence average age at menarche: results from two nationally representative surveys of US girls studied 25 years apart". Pediatrics. 111 (4 Pt 1): 844–850. doi:10.1542/peds.111.4.844. PMID 12671122.
  59. ^ a b Al-Sahab B, Ardern CI, Hamadeh MJ, Tamim H (2010). "Age at menarche in Canada: results from the National Longitudinal Survey of Children & Youth". BMC Public Health. 10 (1): 736. doi:10.1186/1471-2458-10-736. PMC 3001737. PMID 21110899.
  60. ^ a b Hamilton-Fairley D (2004). Obstetrics and Gynaecology (PDF) (2nd ed.). Blackwell Publishing. Archived from the original (PDF) on 2018-10-09. Retrieved 2013-11-09.
  61. ^ a b Apter D (1980). "Serum steroids and pituitary hormones in female puberty: a partly longitudinal study". Clinical Endocrinology. 12 (2): 107–120. doi:10.1111/j.1365-2265.1980.tb02125.x. PMID 6249519. S2CID 19913395.
  62. ^ Marshall & Tanner (1986), pp. 196–197.
  63. ^ Southam AL, Richart RM (1966). "The prognosis for adolescents with menstrual abnormalities". American Journal of Obstetrics and Gynecology. 94 (5): 637–645. doi:10.1016/0002-9378(66)90398-X. PMID 5906589.
  64. ^ "Hips widen during female puberty". Columbia. Retrieved 2013-11-09.
  65. ^ Gungor & Arslanian (2002), pp. 699–700.
  66. ^ Rosenfield (2002), p. [page needed].
  67. ^ Kalloo NB, Gearhart JP, Barrack ER (1993). "Sexually dimorphic expression of estrogen receptors, but not of androgen receptors in human fetal external genitalia". The Journal of Clinical Endocrinology and Metabolism. 77 (3): 692–698. doi:10.1210/jcem.77.3.8370691. PMID 8370691.
  68. ^ Andersson KE, Wein AJ (2004). "Pharmacology of the Lower Urinary Tract: Basis for Current and Future Treatments of Urinary Incontinence". Pharmacological Reviews. 56 (4): 581–631. doi:10.1124/pr.56.4.4. PMID 15602011. S2CID 15746586.
  69. ^ Robinson D, Cardozo L (2011). "Estrogens and the lower urinary tract". Neurourology and Urodynamics. 30 (5): 754–757. doi:10.1002/nau.21106. PMID 21661025. S2CID 36951754.
  70. ^ "Everything You Wanted to Know About Puberty (for Teens) - KidsHealth". kidshealth.org. Retrieved 2019-08-23.
  71. ^ Kaplowitz PB, Slora EJ, Wasserman RC, Pedlow SE, Herman-Giddens ME (2001). "Earlier onset of puberty in girls: relation to increased body mass index and ethnicity". Pediatrics. 108 (2): 347–53. doi:10.1542/peds.108.2.347. PMID 11483799.
  72. ^ Nelson RJ. 2005. Introduction to Behavioral Endocrinology. Sinauer Associates: Massachusetts. p357.
  73. ^ a b Zuckerman D (May 2009). "Early Puberty in Girls". National Research Center for Women and Families. Archived from the original on 2013-11-09. Retrieved 2010-07-13. Based on a publication from The Ribbon, a newsletter of the Cornell University Program on Breast Cancer and Environmental Risk Factors in New York States ((BCERF), Vol 6, No. 1, Winter 2001.)
  74. ^ Mitchell AL, Dwyer A, Pitteloud N, Quinton R (2011). "Genetic basis and variable phenotypic expression of Kallmann syndrome: towards a unifying theory". Trends Endocrinol. Metab. 22 (7): 249–58. doi:10.1016/j.tem.2011.03.002. PMID 21511493. S2CID 23578201.
  75. ^ Hugh Jones, ed. (2008). "Chapter 9. Puberty & Fertility". Testosterone Deficiency in Men. Oxford Endocrinology Library. Oxford University Press. ISBN 978-0-19-954513-1.[page needed]
  76. ^ Finley H. "Average age at menarche in various cultures". Museum of Menstruation and Women's Health. Retrieved 2007-08-02.
  77. ^ Whincup PH, Gilg JA, Odoki K, Taylor SJ, Cook DG (2001). "Age of menarche in contemporary British teenagers: survey of girls born between 1982 and 1986". BMJ. 322 (7294): 1095–1096. doi:10.1136/bmj.322.7294.1095. PMC 31261. PMID 11337438.
  78. ^ "Girls maturing slightly earlier". BBC News. 2001-05-03. Retrieved 2007-08-02.
  79. ^ Rogers L (2010-06-13). "Girls now begin puberty aged 9". The Times. London.
  80. ^ a b c Ge X, Natsuaki MN, Neiderhiser JM, Reiss D (2007). "Genetic and Environmental Influences on Pubertal Timing: Results From Two National Sibling Studies". Journal of Research on Adolescence. 17 (4): 767–788. doi:10.1111/j.1532-7795.2007.00546.x.
  81. ^ Mustanski BS, Viken RJ, Kaprio J, Pulkkinen L, Rose RJ (2004). "Genetic and environmental influences on pubertal development: longitudinal data from Finnish twins at ages 11 and 14". Developmental Psychology. 40 (6): 1188–1198. doi:10.1037/0012-1649.40.6.1188. PMID 15535766.
  82. ^ Treloar SA, Martin NG (1990). "Age at menarche as a fitness trait: nonadditive genetic variance detected in a large twin sample". American Journal of Human Genetics. 47 (1): 137–148. PMC 1683767. PMID 2349942.
  83. ^ Kaprio J, Rimpelä A, Winter T, Viken RJ, Rimpelä M, Rose RJ (1995). "Common genetic influences on BMI and age at menarche". Human Biology; an International Record of Research. 67 (5): 739–753. PMID 8543288.
  84. ^ Comings DE, Muhleman D, Johnson JP, MacMurray JP (2002). "Parent-daughter transmission of the androgen receptor gene as an explanation of the effect of father absence on age of menarche". Child Development. 73 (4): 1046–1051. doi:10.1111/1467-8624.00456. PMID 12146732.
  85. ^ Colborn T, Dumanoski D, Myers JP (1996). Our Stolen Future. Little, Brown. ISBN 0316875465.[page needed]
  86. ^ "Are Bisphenol A (BPA) Plastic Products Safe for Infants and Children?". Archived from the original on 2020-08-06. Retrieved 2013-11-09.
  87. ^ McKenna P (2007-03-05). "Childhood obesity brings early puberty for girls". New Scientist. Archived from the original on 2008-04-19. Retrieved 2010-05-22.
  88. ^ Molly, M. Ginty, "US Girls' Early Puberty Attracts Research Flurry", Women's eNews
  89. ^ Bulik CM, Reba L, Siega-Riz AM, Reichborn-Kjennerud T (2005). "Anorexia nervosa: definition, epidemiology, and cycle of risk". The International Journal of Eating Disorders. 37 (Suppl 1): S2–9, discussion S20–1. doi:10.1002/eat.20107. PMID 15852310.
  90. ^ Topaloglu AK, Reimann F, Guclu M, Yalin AS, Kotan LD, Porter KM, et al. (2008). "TAC3 and TACR3 mutations in familial hypogonadotropic hypogonadism reveal a key role for Neurokinin B in the central control of reproduction". Nature Genetics. 41 (3): 354–358. doi:10.1038/ng.306. PMC 4312696. PMID 19079066.
    Lay summary: "Key to regulation of puberty discovered". (e) Science News. 2008-12-11.
  91. ^ Lehrer S (1984). "Modern correlates of Freudian psychology. Infant sexuality and the unconscious". The American Journal of Medicine. 77 (6): 977–980. doi:10.1016/0002-9343(84)90172-4. PMID 6507468. Archived from the original on 2011-09-21. Retrieved 2009-05-03.
  92. ^ Neill JD (2001). "In Memoriam: Ernst Knobil (1926-2000)". Endocrine Reviews. 22 (6): 721–723. doi:10.1210/edrv.22.6.8566. PMID 11739328. S2CID 1634732.
  93. ^ Boyar R, Finkelstein J, Roffwarg H, Kapen S, Weitzman E, Hellman L (1972). "Synchronization of augmented luteinizing hormone secretion with sleep during puberty". The New England Journal of Medicine. 287 (12): 582–586. doi:10.1056/NEJM197209212871203. PMID 4341276.
  94. ^ Sizonenko PC, Aubert ML (1986). "Neuroendocrine changes characteristic of sexual maturation". Journal of Neural Transmission. Supplementum. 21: 159–181. PMID 3462329.
  95. ^ Rivest RW (1991). "Sexual maturation in female rats: hereditary, developmental and environmental aspects". Experientia. 47 (10): 1027–1038. doi:10.1007/bf01923338. PMID 1936201. S2CID 28120306.
  96. ^ Yellon SM, Newman SW (1991). "A developmental study of the gonadotropin-releasing hormone neuronal system during sexual maturation in the male Djungarian hamster". Biology of Reproduction. 45 (3): 440–446. doi:10.1095/biolreprod45.3.440. PMID 1782292.
  97. ^ Lehrer S (1983). "Puberty and resonance: a hypothesis" (PDF). The Mount Sinai Journal of Medicine, New York. 50 (1): 39–43. PMID 6601758.
  98. ^ Lehrer S (1986). "Rats on 22.5-hr light:dark cycles have vaginal opening earlier than rats on 26-hr light:dark cycles". Journal of Pineal Research. 3 (4): 375–378. doi:10.1111/j.1600-079X.1986.tb00759.x. PMID 3783418. S2CID 41436917.
  99. ^ Vilaplana J, Madrid JA, Sánchez-Vázquez J, Campuzano A, Cambras T, Díez-Noguera A (1995). "Influence of period length of light/dark cycles on the body weight and food intake of young rats". Physiology & Behavior. 58 (1): 9–13. doi:10.1016/0031-9384(95)00021-A. PMID 7667433. S2CID 43118869.
  100. ^ Lehrer S (2015). "Continuation of gradual weight gain necessary for the onset of puberty may be responsible for obesity later in life". Discovery Medicine. 110 (110): 191–196. PMC 4809356. PMID 26562472.
  101. ^ "Sex Determination _ Dr Mahmoud Ahmad Fora". www.just.edu.jo. Retrieved 2022-07-06.
  102. ^ Becker KL (2001). Principles and Practice of Endocrinology and Metabolism. Lippincott Williams & Wilkins. p. 889. ISBN 978-0-7817-1750-2.
  103. ^ Guízar-Vázquez JJ, Rosales-López A, Ortiz-Jalomo R, Nava-Delgado SE, Salamanca-Gómez F (1992). "Edad de aparición de la espermaturia (espermaquia) en 669 niños mexicanos y su relación con caracteres sexuales secundarios y talla" [Age of onset of spermaturia (spermache) in 669 Mexican children and its relation to secondary sexual characteristics and height]. Boletin Medico del Hospital Infantil de Mexico (in Spanish). 49 (1): 12–17. PMID 1304761.

Sources

Further reading

  • Colborn T, Dumanoski D, Myers JP (1996). Our Stolen Future. Little, Brown. ISBN 0316875465.
  • Ducros, A. and Pasquet, P. "Evolution de l'âge d'apparition des premières règles (ménarche) en France". Biométrie Humaine (1978), 13, 35–43.
  • Gluckman PD, Hanson MA (2006). "Evolution, development and timing of puberty". Trends in Endocrinology and Metabolism. 17 (1): 7–12. doi:10.1016/j.tem.2005.11.006. PMID 16311040. S2CID 26141301.
  • Herman-Giddens ME, Slora EJ, Wasserman RC, Bourdony CJ, Bhapkar MV, Koch GG, et al. (1997). "Secondary sexual characteristics and menses in young girls seen in office practice: a study from the Pediatric Research in Office Settings network". Pediatrics. 99 (4): 505–12. doi:10.1542/peds.99.4.505. PMID 9093289. Newer data suggesting that lower age thresholds for evaluation should be used.
  • Plant TM, Lee PA, eds. The Neurobiology of Puberty. Bristol: Society for Endocrinology, 1995. Proceedings of the latest (4th) International Conference on the Control of the Onset of Puberty, containing summaries of current theories of physiological control, as well as GnRH analog treatment.
  • Sizonenko, PC. Role of sex steroids during development—integration Archived 2013-07-04 at the Wayback Machine. in Bourguignon, Jean Pierre & Tony M. Plant. The Onset of Puberty in Perspective: Proceedings of the 5th International Conference on the Control of the Onset of Puberty, Held in Liège, Belgium, 26–28 September 1999. Elsevier. Amsterdam & New York 2000. ISBN 0-444-50296-3. pp 299–306.
  • Tanner JM, Davies PS (1985). "Clinical longitudinal standards for height and height velocity for North American children". The Journal of Pediatrics. 107 (3): 317–29. doi:10.1016/S0022-3476(85)80501-1. PMID 3875704. Highly useful growth charts with integrated standards for stages of puberty.
  • Terasawa E, Fernandez DL (2001). "Neurobiological mechanisms of the onset of puberty in primates". Endocrine Reviews. 22 (1): 111–51. doi:10.1210/edrv.22.1.0418. PMID 11159818.
  • "Research shows how evolution explains age of puberty", ScienceDaily, December 1, 2005
Wikisource has the text of the 1911 Encyclopædia Britannica article "Puberty".
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