Tosufloxacin

Tosufloxacin
Clinical data
AHFS/Drugs.com	International Drug Names
ATC code	J01MA22 (WHO) S01AE09 (WHO);
Identifiers
	IUPAC name 7-(3-Aminopyrrolidin-1-yl)-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid;
CAS Number	100490-36-6 ;
PubChem CID	5517;
ChemSpider	5316 ;
UNII	GHJ553KQPS;
KEGG	D02317 ;
ChEBI	CHEBI:77573 ;
ChEMBL	ChEMBL273348 ;
CompTox Dashboard (EPA)	DTXSID2044135 ;
Chemical and physical data
Formula	C19H15F3N4O3
Molar mass	404.349 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES NC1CCN(C1)c1nc2n(cc(C(O)=O)c(=O)c2cc1F)-c1ccc(F)cc1F;
	InChI InChI=1S/C19H15F3N4O3/c20-9-1-2-15(13(21)5-9)26-8-12(19(28)29)16(27)11-6-14(22)18(24-17(11)26)25-4-3-10(23)7-25/h1-2,5-6,8,10H,3-4,7,23H2,(H,28,29) ; Key:WUWFMDMBOJLQIV-UHFFFAOYSA-N ;
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Tosufloxacin is a fluoroquinolone antibiotic. It has a controversial safety profile in relation to other fluoroquinolones. It is associated with severe thrombocytopenia and nephritis, and hepatotoxicity.^[1] It is sold in Japan under the brand name Ozex.

References

^ Rubinstein E (2001). "History of quinolones and their side effects". Chemotherapy. 47 Suppl 3 (3): 3–8, discussion 44–8. doi:10.1159/000057838. PMID 11549783. S2CID 21890070.

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[1] Rubinstein E (2001). "History of quinolones and their side effects". Chemotherapy. 47 Suppl 3 (3): 3–8, discussion 44–8. doi:10.1159/000057838. PMID 11549783. S2CID 21890070.

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