Interleukin 6 signal transducer (Q21116066)

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P40189

Immunoglobulin-like fold

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P40189

Fibronectin type III, protein family

1 reference

based on heuristic

inferred from protein domain or family

Immunoglobulin C2-set-like, ligand-binding domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Type I cytokine receptor, cytokine-binding domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

interleukin-11 binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40189

leukemia inhibitory factor receptor activity

2 references

17 October 2017

Dual oncostatin M (OSM) receptors. Cloning and characterization of an alternative signaling subunit conferring OSM-specific receptor activation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P40189&geneProductId=UniProtKB:P40189

17 October 2017

Signaling of human ciliary neurotrophic factor (CNTF) revisited. The interleukin-6 receptor can serve as an alpha-receptor for CTNF

http://www.ebi.ac.uk/QuickGO/annotations?protein=P40189&geneProductId=UniProtKB:P40189

ciliary neurotrophic factor receptor binding

1 reference

17 October 2017

Solution Structure of the C-terminal Domain of the Ciliary Neurotrophic Factor (CNTF) Receptor and Ligand Free Associations among Components of the CNTF Receptor Complex

http://www.ebi.ac.uk/QuickGO/annotations?protein=P40189&geneProductId=UniProtKB:P40189

interleukin-27 receptor activity

1 reference

8 April 2019

WSX-1 and glycoprotein 130 constitute a signal-transducing receptor for IL-27

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40189

ciliary neurotrophic factor receptor activity

1 reference

8 April 2019

Signaling of human ciliary neurotrophic factor (CNTF) revisited. The interleukin-6 receptor can serve as an alpha-receptor for CTNF

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40189

cytokine receptor activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=P40189&geneProductId=UniProtKB:P40189

1 reference

17 October 2017

protein homodimerization activity

1 reference

8 April 2019

LIFR beta and gp130 as heterodimerizing signal transducers of the tripartite CNTF receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40189

interleukin-6 receptor binding

1 reference

17 October 2017

Hexameric structure and assembly of the interleukin-6/IL-6 alpha-receptor/gp130 complex

http://www.ebi.ac.uk/QuickGO/annotations?protein=P40189&geneProductId=UniProtKB:P40189

growth factor binding

1 reference

8 April 2019

Dual oncostatin M (OSM) receptors. Cloning and characterization of an alternative signaling subunit conferring OSM-specific receptor activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40189

interleukin-11 receptor activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40189

oncostatin-M receptor activity

1 reference

17 October 2017

Dual oncostatin M (OSM) receptors. Cloning and characterization of an alternative signaling subunit conferring OSM-specific receptor activation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P40189&geneProductId=UniProtKB:P40189

interleukin-6 receptor activity

interleukin-6 binding

1 reference

17 October 2017

Hexameric structure and assembly of the interleukin-6/IL-6 alpha-receptor/gp130 complex

http://www.ebi.ac.uk/QuickGO/annotations?protein=P40189&geneProductId=UniProtKB:P40189

protein binding

9 references

8 April 2019

The coiled-coil domain of Stat3 is essential for its SH2 domain-mediated receptor binding and subsequent activation induced by epidermal growth factor and interleukin-6

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40189

8 April 2019

Structural Organization of a Full-Length gp130/LIF-R Cytokine Receptor Transmembrane Complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40189

8 April 2019

Biochemical and functional analyses of gp130 mutants unveil JAK1 as a novel therapeutic target in human inflammatory hepatocellular adenoma

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40189

8 April 2019

The N-terminal cytokine binding domain of LIFR is required for CNTF binding and signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40189

8 April 2019

Convergent mechanisms for recognition of divergent cytokines by the shared signaling receptor gp130

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40189

8 April 2019

Detection of direct binding of human herpesvirus 8-encoded interleukin-6 (vIL-6) to both gp130 and IL-6 receptor (IL-6R) and identification of amino acid residues of vIL-6 important for IL-6R-dependent and -independent signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40189

8 April 2019

Differential activation of acute phase response factor/STAT3 and STAT1 via the cytoplasmic domain of the interleukin 6 signal transducer gp130. I. Definition of a novel phosphotyrosine motif mediating STAT1 activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40189

8 April 2019

Dual oncostatin M (OSM) receptors. Cloning and characterization of an alternative signaling subunit conferring OSM-specific receptor activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40189

8 April 2019

Promyelocytic leukemia protein interacts with the apoptosis-associated speck-like protein to limit inflammasome activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40189

interleukin-6 receptor activity

Signaling of human ciliary neurotrophic factor (CNTF) revisited. The interleukin-6 receptor can serve as an alpha-receptor for CTNF

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40189

8 April 2019

Molecular cloning and expression of an IL-6 signal transducer, gp130

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40189

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40189

leukemia inhibitory factor receptor activity

Signaling of human ciliary neurotrophic factor (CNTF) revisited. The interleukin-6 receptor can serve as an alpha-receptor for CTNF

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40189

8 April 2019

Dual oncostatin M (OSM) receptors. Cloning and characterization of an alternative signaling subunit conferring OSM-specific receptor activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40189

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40189

oncostatin-M receptor activity

ciliary neurotrophic factor receptor binding

cytokine binding

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40189

identical protein binding

1 reference

8 April 2019

Biochemical and functional analyses of gp130 mutants unveil JAK1 as a novel therapeutic target in human inflammatory hepatocellular adenoma

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40189

cell component

extracellular exosome

integral component of membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40189

1 reference

8 April 2019

cell body

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40189

ciliary neurotrophic factor receptor complex

1 reference

17 October 2017

Solution Structure of the C-terminal Domain of the Ciliary Neurotrophic Factor (CNTF) Receptor and Ligand Free Associations among Components of the CNTF Receptor Complex

http://www.ebi.ac.uk/QuickGO/annotations?protein=P40189&geneProductId=UniProtKB:P40189

membrane

http://www.ebi.ac.uk/QuickGO/annotations?protein=P40189&geneProductId=UniProtKB:P40189

3 references

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P40189&geneProductId=UniProtKB:P40189

17 October 2017

17 October 2017

Defining the membrane proteome of NK cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P40189&geneProductId=UniProtKB:P40189

soma

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40189

dendrite

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40189

interleukin-6 receptor complex

3 references

17 October 2017

Molecular cloning and expression of an IL-6 signal transducer, gp130

http://www.ebi.ac.uk/QuickGO/annotations?protein=P40189&geneProductId=UniProtKB:P40189

17 October 2017

Hexameric structure and assembly of the interleukin-6/IL-6 alpha-receptor/gp130 complex

http://www.ebi.ac.uk/QuickGO/annotations?protein=P40189&geneProductId=UniProtKB:P40189

17 October 2017

Signaling of human ciliary neurotrophic factor (CNTF) revisited. The interleukin-6 receptor can serve as an alpha-receptor for CTNF

http://www.ebi.ac.uk/QuickGO/annotations?protein=P40189&geneProductId=UniProtKB:P40189

oncostatin-M receptor complex

1 reference

17 October 2017

Dual oncostatin M (OSM) receptors. Cloning and characterization of an alternative signaling subunit conferring OSM-specific receptor activation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P40189&geneProductId=UniProtKB:P40189

external side of plasma membrane

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P40189&geneProductId=UniProtKB:P40189

extracellular space

1 reference

17 October 2017

Soluble forms of the interleukin-6 signal-transducing receptor component gp130 in human serum possessing a potential to inhibit signals through membrane-anchored gp130

http://www.ebi.ac.uk/QuickGO/annotations?protein=P40189&geneProductId=UniProtKB:P40189

interleukin-6 receptor complex

Signaling of human ciliary neurotrophic factor (CNTF) revisited. The interleukin-6 receptor can serve as an alpha-receptor for CTNF

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40189

8 April 2019

Molecular cloning and expression of an IL-6 signal transducer, gp130

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40189

8 April 2019

Hexameric structure and assembly of the interleukin-6/IL-6 alpha-receptor/gp130 complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40189

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40189

oncostatin-M receptor complex

membrane

HDA

3 references

receptor complex

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40189

extracellular exosome

HDA

1 reference

8 April 2019

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40189

ciliary neurotrophic factor receptor complex

HDA

regulation of Notch signaling pathway

biological process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40189

positive regulation of cardiac muscle hypertrophy

1 reference

8 April 2019

Signal transducer and activator of transcription 3 is required for glycoprotein 130-mediated induction of vascular endothelial growth factor in cardiac myocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40189

negative regulation of apoptotic process

1 reference

8 April 2019

Survival pathways in hypertrophy and heart failure: the gp130-STAT3 axis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40189

negative regulation of interleukin-6-mediated signaling pathway

1 reference

17 October 2017

Soluble forms of the interleukin-6 signal-transducing receptor component gp130 in human serum possessing a potential to inhibit signals through membrane-anchored gp130

http://www.ebi.ac.uk/QuickGO/annotations?protein=P40189&geneProductId=UniProtKB:P40189

interleukin-11-mediated signaling pathway

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40189

oncostatin-M-mediated signaling pathway

1 reference

8 April 2019

Dual oncostatin M (OSM) receptors. Cloning and characterization of an alternative signaling subunit conferring OSM-specific receptor activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40189

signal transduction

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40189

interleukin-27-mediated signaling pathway

1 reference

17 October 2017

WSX-1 and glycoprotein 130 constitute a signal-transducing receptor for IL-27

http://www.ebi.ac.uk/QuickGO/annotations?protein=P40189&geneProductId=UniProtKB:P40189

positive regulation of adaptive immune response

1 reference

8 April 2019

WSX-1 and glycoprotein 130 constitute a signal-transducing receptor for IL-27

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40189

ciliary neurotrophic factor-mediated signaling pathway

1 reference

8 April 2019

Signaling of human ciliary neurotrophic factor (CNTF) revisited. The interleukin-6 receptor can serve as an alpha-receptor for CTNF

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40189

leukemia inhibitory factor signaling pathway

2 references

viral process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40189

1 reference

8 April 2019

positive regulation of T cell proliferation

1 reference

17 October 2017

WSX-1 and glycoprotein 130 constitute a signal-transducing receptor for IL-27

http://www.ebi.ac.uk/QuickGO/annotations?protein=P40189&geneProductId=UniProtKB:P40189

interleukin-6-mediated signaling pathway

positive regulation of acute inflammatory response

1 reference

8 April 2019

Dual oncostatin M (OSM) receptors. Cloning and characterization of an alternative signaling subunit conferring OSM-specific receptor activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40189

positive regulation of astrocyte differentiation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40189

positive regulation of osteoblast differentiation

1 reference

8 April 2019

Gp130 activation by soluble interleukin-6 receptor/interleukin-6 enhances osteoblastic differentiation of human bone marrow-derived mesenchymal stem cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40189

glycogen metabolic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40189

positive regulation of vascular endothelial growth factor production

1 reference

8 April 2019

Signal transducer and activator of transcription 3 is required for glycoprotein 130-mediated induction of vascular endothelial growth factor in cardiac myocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40189

positive regulation of cell population proliferation

Dual oncostatin M (OSM) receptors. Cloning and characterization of an alternative signaling subunit conferring OSM-specific receptor activation

3 references

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P40189&geneProductId=UniProtKB:P40189

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P40189&geneProductId=UniProtKB:P40189

17 October 2017

Molecular cloning and expression of an IL-6 signal transducer, gp130

http://www.ebi.ac.uk/QuickGO/annotations?protein=P40189&geneProductId=UniProtKB:P40189

positive regulation of tyrosine phosphorylation of STAT protein

1 reference

17 October 2017

WSX-1 and glycoprotein 130 constitute a signal-transducing receptor for IL-27

http://www.ebi.ac.uk/QuickGO/annotations?protein=P40189&geneProductId=UniProtKB:P40189

interleukin-12-mediated signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?protein=P40189&geneProductId=UniProtKB:P40189

1 reference

17 October 2017

positive regulation of cell population proliferation

Dual oncostatin M (OSM) receptors. Cloning and characterization of an alternative signaling subunit conferring OSM-specific receptor activation

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40189

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40189

8 April 2019

Molecular cloning and expression of an IL-6 signal transducer, gp130

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40189

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40189

cytokine-mediated signaling pathway

positive regulation of tyrosine phosphorylation of STAT protein

interleukin-6-mediated signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40189

3 references

8 April 2019

8 April 2019

Signaling of human ciliary neurotrophic factor (CNTF) revisited. The interleukin-6 receptor can serve as an alpha-receptor for CTNF

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40189

8 April 2019

Molecular cloning and expression of an IL-6 signal transducer, gp130

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40189

interleukin-35-mediated signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40189

1 reference

8 April 2019

D12.776.543.750.705.852.420.400.500

Identifiers

MeSH descriptor ID

D050822

subject named as

Cytokine Receptor gp130

0 references

MeSH tree code

0 references

D12.776.543.750.705.852.420.560.249

0 references

D12.776.543.750.705.852.555.600.500

0 references

D12.776.543.750.705.852.583.500

0 references

D12.776.543.750.750.400.550.250.500

0 references

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

13 November 2019

0 references

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

0 references

Microsoft Academic ID

0 references

1 reference

26 January 2022

https://docs.openalex.org/download-snapshot/snapshot-data-format

1 reference

21 March 2016

1 reference

21 March 2016

1 reference

21 March 2016

1 reference

21 March 2016

1 reference

21 March 2016

1 reference

21 March 2016

1 reference

21 March 2016

1 reference

21 March 2016

inferred by common MeSH mappings on source and on Wikidata

1 reference

UMLS 2023