KRAS proto-oncogene, GTPase (Q4042017)

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P01116

P-loop containing nucleoside triphosphate hydrolase

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P01116

Small GTP-binding protein domain family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01116

1 reference

9 May 2019

LRR domain binding

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01116

GDP binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01116

GMP binding

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01116

identical protein binding

IPI

1 reference

17 October 2017

GTP-Dependent K-Ras Dimerization

GOA

curator

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01116&geneProductId=UniProtKB:P01116

IPI

GTPase activity

3 references

GTP binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01116

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01116

9 May 2019

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01116

cell component

cytosol

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01116

1 reference

9 May 2019

membrane

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01116&geneProductId=UniProtKB:P01116

4 references

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01116&geneProductId=UniProtKB:P01116

17 October 2017

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01116&geneProductId=UniProtKB:P01116

17 October 2017

Defining the membrane proteome of NK cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01116&geneProductId=UniProtKB:P01116

focal adhesion

1 reference

17 October 2017

Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01116&geneProductId=UniProtKB:P01116

extrinsic component of cytoplasmic side of plasma membrane

1 reference

9 May 2019

Small molecule inhibition of the KRAS-PDEδ interaction impairs oncogenic KRAS signalling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01116

mitochondrion

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01116

membrane raft

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01116

focal adhesion

HDA

1 reference

9 May 2019

Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01116

HDA

membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01116

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01116

9 May 2019

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01116

9 May 2019

Defining the membrane proteome of NK cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01116

HDA

plasma membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01116

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01116

9 May 2019

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01116

biological process

visual learning

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01116

negative regulation of neuron apoptotic process

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01116

response to mineralocorticoid

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01116

positive regulation of protein phosphorylation

1 reference

9 May 2019

Oncogenic Ras and B-Raf proteins positively regulate death receptor 5 expression through co-activation of ERK and JNK signaling

GOA

curator

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01116

regulation of long-term neuronal synaptic plasticity

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01116

regulation of protein stability

1 reference

9 May 2019

A KRAS-directed transcriptional silencing pathway that mediates the CpG island methylator phenotype

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01116

epidermal growth factor receptor signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01116&geneProductId=UniProtKB:P01116

1 reference

17 October 2017

positive regulation of MAP kinase activity

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01116

cytokine-mediated signaling pathway

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01116

negative regulation of cell differentiation

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01116

stimulatory C-type lectin receptor signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01116

1 reference

9 May 2019

response to glucocorticoid

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01116

MAPK cascade

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01116

1 reference

9 May 2019

axon guidance

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01116&geneProductId=UniProtKB:P01116

1 reference

17 October 2017

Fc-epsilon receptor signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01116&geneProductId=UniProtKB:P01116

1 reference

17 October 2017

positive regulation of nitric-oxide synthase activity

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01116

forebrain astrocyte development

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01116

endocrine signaling

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01116

positive regulation of NF-kappaB transcription factor activity

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01116

homeostasis of number of cells within a tissue

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01116

striated muscle cell differentiation

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01116

epithelial tube branching involved in lung morphogenesis

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01116

regulation of synaptic transmission, GABAergic

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01116

actin cytoskeleton organization

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01116

leukocyte migration

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01116&geneProductId=UniProtKB:P01116

1 reference

17 October 2017

signal transduction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01116

1 reference

9 May 2019

positive regulation of Rac protein signal transduction

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01116

ERBB2 signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01116&geneProductId=UniProtKB:P01116

1 reference

17 October 2017

liver development

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01116

positive regulation of cellular senescence

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01116

female pregnancy

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01116

response to isolation stress

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01116

Ras protein signal transduction

physically interacts with

3 references

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

8024

English

small GTP-binding protein domain

17 August 2016

Gene Atlas image

PBB GE KRAS 204009 s at fs.png
732 × 530; 11 KB

0 references

has part(s)

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P01116

Identifiers

MeSH descriptor ID

C117307

subject named as

KRAS protein, human

0 references

1 reference

30 May 2020

1 reference

30 May 2020

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30 May 2020

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30 May 2020

1 reference

13 November 2019

1 reference

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9 August 2016

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9 August 2016

inferred by common MeSH mappings on source and on Wikidata

1 reference

UMLS 2023