Aminoglycoside Antibiotics: New Insights into the Biosynthetic Machinery of Old Drugs (Q38604106)

4 September 2017

title

Aminoglycoside Antibiotics: New Insights into the Biosynthetic Machinery of Old Drugs (English)

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4 September 2017

Fumitaka Kudo

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Tadashi Eguchi

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12 October 2015

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4 September 2017

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4 September 2017

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4 September 2017

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4 September 2017

page(s)

4-18

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GENTAMICIN, A NEW ANTIBIOTIC COMPLEX FROM MICROMONOSPORA.

4 September 2017

cites work

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Aminoglycoside antibiotics in the 21st century.

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The bacterial ribosome as a target for antibiotics

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Functional insights from the structure of the 30S ribosomal subunit and its interactions with antibiotics

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The Molecular Basis for A‐Site Mutations Conferring Aminoglycoside Resistance: Relationship between Ribosomal Susceptibility and X‐ray Crystal Structures

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Aminoglycoside modifying enzymes

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The future of aminoglycosides: the end or renaissance?

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In vitro read-through of phenylalanine hydroxylase (PAH) nonsense mutations using aminoglycosides: a potential therapy for phenylketonuria

21 January 2018

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Combating drug-resistant bacteria: small molecule mimics of plasmid incompatibility as antiplasmid compounds

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Insight into the mechanisms of aminoglycoside derivatives interaction with HIV-1 entry steps and viral gene transcription

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Structure-guided discovery of a novel aminoglycoside conjugate targeting HIV-1 RNA viral genome

21 January 2018

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Antifungal Amphiphilic Aminoglycosides

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Structure-activity relationships for antibacterial to antifungal conversion of kanamycin to amphiphilic analogues.

21 January 2018

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Self-assembled lamellar complexes of siRNA with lipidic aminoglycoside derivatives promote efficient siRNA delivery and interference

21 January 2018

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A peptide nucleic acid-aminosugar conjugate targeting transactivation response element of HIV-1 RNA genome shows a high bioavailability in human cells and strongly inhibits tat-mediated transactivation of HIV-1 transcription

21 January 2018

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Modifications of aminoglycoside antibiotics targeting RNA.

21 January 2018

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New developments in aminoglycoside therapy and ototoxicity

21 January 2018

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Designer aminoglycosides: the race to develop improved antibiotics and compounds for the treatment of human genetic diseases

21 January 2018

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Genetic analysis of interactions with eukaryotic rRNA identify the mitoribosome as target in aminoglycoside ototoxicity

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Dissociation of antibacterial activity and aminoglycoside ototoxicity in the 4-monosubstituted 2-deoxystreptamine apramycin

21 January 2018

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Designer aminoglycosides that selectively inhibit cytoplasmic rather than mitochondrial ribosomes show decreased ototoxicity: a strategy for the treatment of genetic diseases

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Designer aminoglycosides prevent cochlear hair cell loss and hearing loss

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Natural products and synthetic biology

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Extended sequence and functional analysis of the butirosin biosynthetic gene cluster in Bacillus circulans SANK 72073.

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Biosynthetic genes for aminoglycoside antibiotics

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Biosynthesis of aminocyclitol-aminoglycoside antibiotics and related compounds

21 January 2018

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Structure of 2-deoxy-scyllo-inosose synthase, a key enzyme in the biosynthesis of 2-deoxystreptamine-containing aminoglycoside antibiotics, in complex with a mechanism-based inhibitor and NAD+

21 January 2018

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Structure of dehydroquinate synthase reveals an active site capable of multistep catalysis

21 January 2018

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Biosynthesis of aminoglycoside antibiotics: cloning, expression and characterisation of an aminotransferase involved in the pathway to 2-deoxystreptamine

21 January 2018

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Biosynthesis of 2-deoxystreptamine by three crucial enzymes in Streptomyces fradiae NBRC 12773.

21 January 2018

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Characterization and mechanistic study of a radical SAM dehydrogenase in the biosynthesis of butirosin

21 January 2018

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Mechanistic study on the reaction of a radical SAM dehydrogenase BtrN by electron paramagnetic resonance spectroscopy

21 January 2018

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Stereochemical recognition of doubly functional aminotransferase in 2-deoxystreptamine biosynthesis.

21 January 2018

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The neomycin biosynthetic gene cluster of Streptomyces fradiae NCIMB 8233: characterisation of an aminotransferase involved in the formation of 2-deoxystreptamine

21 January 2018

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Involvement of two distinct N-acetylglucosaminyltransferases and a dual-function deacetylase in neomycin biosynthesis.

21 January 2018

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Characterization of the enzyme BtrD from Bacillus circulans and revision of its functional assignment in the biosynthesis of butirosin

21 January 2018

1 reference

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Elaboration of neosamine rings in the biosynthesis of neomycin and butirosin

21 January 2018

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Formation of unusual sugars: mechanistic studies and biosynthetic applications

21 January 2018

1 reference

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Unique O-ribosylation in the biosynthesis of butirosin

21 January 2018

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Enzymatic preparation of neomycin C from ribostamycin.

21 January 2018

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The oxidoreductases LivQ and NeoQ are responsible for the different 6'-modifications in the aminoglycosides lividomycin and neomycin

21 January 2018

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Biosynthesis of the unique amino acid side chain of butirosin: possible protective-group chemistry in an acyl carrier protein-mediated pathway

21 January 2018

1 reference

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Biosynthesis of butirosin: transfer and deprotection of the unique amino acid side chain

21 January 2018

1 reference

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Chemoenzymatic acylation of aminoglycoside antibiotics

21 January 2018

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Biosynthesis of 2-deoxystreptamine-containing aminoglycoside antibiotics

21 January 2018

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The biosynthesis of 3-amino-5-hydroxybenzoic acid (AHBA), the precursor of mC7N units in ansamycin and mitomycin antibiotics: a review.

21 January 2018

1 reference

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Discovery of parallel pathways of kanamycin biosynthesis allows antibiotic manipulation

21 January 2018

1 reference

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The last step of kanamycin biosynthesis: unique deamination reaction catalyzed by the α-ketoglutarate-dependent nonheme iron dioxygenase KanJ and the NADPH-dependent reductase KanK.

21 January 2018

1 reference

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Gene cluster in Micromonospora echinospora ATCC15835 for the biosynthesis of the gentamicin C complex

21 January 2018

1 reference

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Genetic dissection of the biosynthetic route to gentamicin A2 by heterologous expression of its minimal gene set.

21 January 2018

1 reference

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Delineating the biosynthesis of gentamicin x2, the common precursor of the gentamicin C antibiotic complex

21 January 2018

1 reference

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Specificity and promiscuity at the branch point in gentamicin biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FTCR.201500210

Biosynthesis of Epimers C2 and C2a in the Gentamicin C Complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FTCR.201500210

GenK-catalyzed C-6' methylation in the biosynthesis of gentamicin: isolation and characterization of a cobalamin-dependent radical SAM enzyme.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FTCR.201500210

Mechanistic diversity of radical S-adenosylmethionine (SAM)-dependent methylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FTCR.201500210

Radical-mediated enzymatic methylation: a tale of two SAMS

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FTCR.201500210

Consecutive radical S-adenosylmethionine methylations form the ethyl side chain in thienamycin biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FTCR.201500210

Construction of kanamycin B overproducing strain by genetic engineering of Streptomyces tenebrarius

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FTCR.201500210

Characterization and mechanistic studies of DesII: a radical S-adenosyl-L-methionine enzyme involved in the biosynthesis of TDP-D-desosamine

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FTCR.201500210

Enzymology of aminoglycoside biosynthesis-deduction from gene clusters

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FTCR.201500210

Possible evolutionary relationships between streptomycin and bluensomycin biosynthetic pathways: detection of novel inositol kinase and O-carbamoyltransferase activities

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FTCR.201500210

Identification of stsC , the gene encoding the l -glutamine: scyllo -inosose aminotransferase from streptomycin-producing Streptomycetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FTCR.201500210

Crystal structure of L-arginine:inosamine-phosphate amidinotransferase StrB1 from Streptomyces griseus: an enzyme involved in streptomycin biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FTCR.201500210

The StrQ protein encoded in the gene cluster for 5'-hydroxystreptomycin of Streptomyces glaucescens GLA.0 is a alpha-D-glucose-1-phosphate cytidylyltransferase (CDP-D-glucose synthase).

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FTCR.201500210

Genetics of streptomycin production in Streptomyces griseus: nucleotide sequence of five genes, strFGHIK, including a phosphatase gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FTCR.201500210

X-ray analysis of butirosin biosynthetic enzyme BtrN redefines structural motifs for AdoMet radical chemistry

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FTCR.201500210

Importance of specific hydrogen-bond donor-acceptor interactions for the key carbocycle-forming reaction catalyzed by 2-deoxy-scyllo-inosose synthase in the biosynthesis of 2-deoxystreptamine-containing aminocyclitol antibiotics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FTCR.201500210

Beyond directed evolution—semi-rational protein engineering and design

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FTCR.201500210

Radical S-adenosylmethionine enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FTCR.201500210

Butirosin-biosynthetic Gene Cluster from Bacillus circulans.

21 January 2018

1 reference

12 April 2024

https://opencitations.net/index/api/v1/citations/10.7164/ANTIBIOTICS.53.1158

Biosynthesis of astromicin and related antibiotics. II. Biosynthetic studies with blocked mutants of Micromonospora olivasterospora

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12 April 2024

https://opencitations.net/index/api/v1/citations/10.7164/ANTIBIOTICS.37.1670

Organization and nature of fortimicin A (astromicin) biosynthetic genes studied using a cosmid library of Micromonospora olivasterospora DNA

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11 May 2024

https://opencitations.net/index/api/v1/citations/10.1007/BF00279641

Identifiers

DOI

10.1002/TCR.201500210

1 reference

4 September 2017

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