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. 1996 Jun;14(8-10):1043-6.
doi: 10.1016/s0731-7085(96)01753-0.

Concentrations of L-dopa in plasma and plasma ultrafiltrates

V Rizzo  1 , M Memmi, R Moratti, G Melzi d'Eril, E Perucca
Affiliations

Concentrations of L-dopa in plasma and plasma ultrafiltrates

V Rizzo et al. J Pharm Biomed Anal. 1996 Jun.

Abstract

A sensitive and specific procedure is described for the determination of therapeutically relevant concentrations of L-dopa in plasma and plasma ultrafiltrates (free fraction) by high performance liquid chromatography with electrochemical detection. In plasma samples from healthy adult subjects (n = 15) spiked with L-dopa (500 micrograms l-1) the free fraction averaged 76 +/- = 8% (range 61-84%). Free fraction values increased by 38% with increasing plasma concentrations of L-dopa from 100-5000 micrograms 1-1. L-dopa free fraction was not affect by the presence of 3-O-methyl-dopa at concentrations up to 10,000 micrograms l-1.

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