Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 Jul;11(Suppl 4):S479-S484.
doi: 10.1016/j.jcot.2020.04.013. Epub 2020 Apr 18.

Epidemiology and survival of liposarcoma and its subtypes: A dual database analysis

Kamil M Amer  1 , Dominick V Congiusta  1 , Jennifer E Thomson  1 , Samer Elsamna  1 , Iftikhar Chaudhry  1 , Anthony Bozzo  2 , Rami Amer  1 , Brianna Siracuse  1 , Michelle Ghert  2 , Kathleen S Beebe  1
Affiliations

Epidemiology and survival of liposarcoma and its subtypes: A dual database analysis

Kamil M Amer et al. J Clin Orthop Trauma. 2020 Jul.

Abstract

Purpose: Liposarcoma (LPS) is a one of the most commonly diagnosed soft tissue sarcomas. Little is known about the epidemiology and prognosis of each subtype. We present an analysis of epidemiology and survival of the subtypes of LPS using a national database.

Methods: We queried the Survival Epidemiology, and End Results (SEER) and the Canadian Institute for Clinical Evaluative Sciences (ICES) databases for data on 7 types of LPS. Pearson's chi square was used to determine associations between variables and subtypes. Kaplan-Meier and Cox Regression analyses were performed for two tests: one using SEER data and the other using variables common to both SEER and ICES.

Results: The well-differentiated subtype was the most common subtype identified. Metastatic disease was associated with decreased survival across all subtypes and age >35 was associated with decreased survival in well-differentiated and myxoid subtypes. Tumor grade was associated with decreased survival in the well-differentiated, myxoid, mixed, and round cell subtypes. In the secondary analysis, age >35 was associated with decreased survival in the myxoid subtype.

Conclusions: The prognosis of liposarcoma differs greatly by subtype. Clinicians should account for patient factors at the time of diagnosis to best navigate treatment of their patients.

Keywords: ICES; Liposarcoma; SEER; Subtypes.

PubMed Disclaimer

Conflict of interest statement

All authors have declared that they have no conflicts of interest for this project. This manuscript has not been submitted to, nor is under review at, another journal or other publishing venue. The authors have no affiliation with any organization with a direct or indirect financial interest in the subject matter discussed in the manuscript.

Figures

Fig. 1
Fig. 1
SEER† survival function, by subtype. † Surveillance, Epidemiology, and End Results Program Database.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Gadgeel S.M., Harlan L.C., Zeruto C.A., Osswald M., Schwartz A.G. Patterns of care in a population-based sample of soft tissue sarcoma patients in the United States. Cancer. 2009;115:2744–2754. doi: 10.1002/cncr.24307. - DOI - PMC - PubMed
    1. Henze J., Bauer S. Liposarcomas. Hematol Oncol Clin North Am. 2013;27:939–955. doi: 10.1016/j.hoc.2013.07.010. - DOI - PubMed
    1. Weiss S.W. Lipomatous tumors. Monogr Pathol. 1996;38:207–239. - PubMed
    1. El Ouni F., Jemni H., Trabelsi A. Liposarcoma of the extremities: MR imaging features and their correlation with pathologic data. Orthop Traumatol Surg Res. 2010;96:876–883. doi: 10.1016/j.otsr.2010.05.010. - DOI - PubMed
    1. Crago A.M., Liposarcoma M. A. Dickson. Multimodality management and future targeted therapies. Surg Oncol Clin N Am. 2016;25:761–773. doi: 10.1016/j.soc.2016.05.007. - DOI - PMC - PubMed