Taste buds: cells, signals and synapses
- PMID: 28655883
- PMCID: PMC5958546
- DOI: 10.1038/nrn.2017.68
Taste buds: cells, signals and synapses
Abstract
The past decade has witnessed a consolidation and refinement of the extraordinary progress made in taste research. This Review describes recent advances in our understanding of taste receptors, taste buds, and the connections between taste buds and sensory afferent fibres. The article discusses new findings regarding the cellular mechanisms for detecting tastes, new data on the transmitters involved in taste processing and new studies that address longstanding arguments about taste coding.
Conflict of interest statement
The authors declare no competing interests.
Figures
Similar articles
-
Processing umami and other tastes in mammalian taste buds.Ann N Y Acad Sci. 2009 Jul;1170:60-5. doi: 10.1111/j.1749-6632.2009.04107.x. Ann N Y Acad Sci. 2009. PMID: 19686109 Free PMC article. Review.
-
"Tripartite Synapses" in Taste Buds: A Role for Type I Glial-like Taste Cells.J Neurosci. 2021 Dec 1;41(48):9860-9871. doi: 10.1523/JNEUROSCI.1444-21.2021. Epub 2021 Oct 25. J Neurosci. 2021. PMID: 34697094 Free PMC article.
-
Signal transduction and information processing in mammalian taste buds.Pflugers Arch. 2007 Aug;454(5):759-76. doi: 10.1007/s00424-007-0247-x. Epub 2007 Apr 28. Pflugers Arch. 2007. PMID: 17468883 Free PMC article. Review.
-
Cellular mechanisms in taste buds.Bull Tokyo Dent Coll. 2007 Nov;48(4):151-61. doi: 10.2209/tdcpublication.48.151. Bull Tokyo Dent Coll. 2007. PMID: 18360101 Review.
-
Neuromodulation of transduction and signal processing in the end organs of taste.Chem Senses. 1996 Jun;21(3):353-65. doi: 10.1093/chemse/21.3.353. Chem Senses. 1996. PMID: 8670715 Review.
Cited by
-
Tuft cells in the intestine, immunity and beyond.Nat Rev Gastroenterol Hepatol. 2024 Sep 26. doi: 10.1038/s41575-024-00978-1. Online ahead of print. Nat Rev Gastroenterol Hepatol. 2024. PMID: 39327439 Review.
-
Biomimetic Neuromorphic Sensory System via Electrolyte Gated Transistors.Sensors (Basel). 2024 Jul 29;24(15):4915. doi: 10.3390/s24154915. Sensors (Basel). 2024. PMID: 39123962 Free PMC article. Review.
-
Bitter tastants relax the mouse gallbladder smooth muscle independent of signaling through tuft cells and bitter taste receptors.Sci Rep. 2024 Aug 8;14(1):18447. doi: 10.1038/s41598-024-69287-6. Sci Rep. 2024. PMID: 39117690 Free PMC article.
-
Umami Characteristics and Taste Improvement Mechanism of Meat.Food Sci Anim Resour. 2024 May;44(3):515-532. doi: 10.5851/kosfa.2024.e29. Epub 2024 May 1. Food Sci Anim Resour. 2024. PMID: 38765277 Free PMC article. Review.
-
Peripheral preprocessing in Drosophila facilitates odor classification.Proc Natl Acad Sci U S A. 2024 May 21;121(21):e2316799121. doi: 10.1073/pnas.2316799121. Epub 2024 May 16. Proc Natl Acad Sci U S A. 2024. PMID: 38753511 Free PMC article.
References
-
- Zhang Y, et al. Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways. Cell. 2003;112:293–301. This study demonstrates that sweet-taste and bitter-taste receptors signal via a common pathway that includes PLCβ2 and TRPM5. Mice lacking the genes that encode these signalling proteins are shown to lose taste sensitivity for sweet, bitter and umami. - PubMed
-
- Clapp TR, Yang R, Stoick CL, Kinnamon SC, Kinnamon JC. Morphologic characterization of rat taste receptor cells that express components of the phospholipase C signaling pathway. J. Comp. Neurol. 2004;468:311–321. - PubMed
-
- DeFazio RA, et al. Separate populations of receptor cells and presynaptic cells in mouse taste buds. J. Neurosci. 2006;26:3971–3980. This study uses Ca2+ imaging and single-cell reverse transcription PCR to show that cells with taste GPCRs (T1Rs and T2Rs) and their downstream effectors are distinct from taste cells that express proteins for vesicular neurotransmitter release. - PMC - PubMed
Publication types
MeSH terms
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
Miscellaneous