Molecular Mechanisms and Novel Therapeutic Approaches to Rhabdomyolysis-Induced Acute Kidney Injury
- PMID: 26512883
- DOI: 10.1159/000368528
Molecular Mechanisms and Novel Therapeutic Approaches to Rhabdomyolysis-Induced Acute Kidney Injury
Abstract
Rhabdomyolysis is a syndrome caused by injury to skeletal muscle that usually leads to acute kidney injury (AKI). Rhabdomyolysis has been linked to different conditions, including severe trauma and intense physical exercise. Myoglobin-induced renal toxicity plays a key role in rhabdomyolysis-associated kidney damage by increasing oxidative stress, inflammation, endothelial dysfunction, vasoconstriction, and apoptosis. New drugs that target the harmful effects of myoglobin have been recently developed, and some have been proven to be successful in animal models of acute renal failure secondary to rhabdomyolysis. This review aims to provide a comprehensive and updated overview of the pathological mechanisms of renal damage and describes new therapeutic approaches to this condition based on novel compounds that target key pathways involved in myoglobin-mediated kidney damage.
© 2015 The Author(s) Published by S. Karger AG, Basel.
Similar articles
-
Curcumin reduces renal damage associated with rhabdomyolysis by decreasing ferroptosis-mediated cell death.FASEB J. 2019 Aug;33(8):8961-8975. doi: 10.1096/fj.201900077R. Epub 2019 Apr 29. FASEB J. 2019. PMID: 31034781
-
Ulinastatin Alleviates Rhabdomyolysis-Induced Acute Kidney Injury by Suppressing Inflammation and Apoptosis via Inhibiting TLR4/NF-κB Signaling Pathway.Inflammation. 2022 Oct;45(5):2052-2065. doi: 10.1007/s10753-022-01675-4. Epub 2022 Jun 6. Inflammation. 2022. PMID: 35668155
-
[Main mechanisms of rhabdomyolysis-caused kidney injury and their correction by organospecific peptides].Biofizika. 2014 Sep-Oct;59(5):1023-6. Biofizika. 2014. PMID: 25730989 Russian.
-
Mechanism-based therapeutic approaches to rhabdomyolysis-induced renal failure.Free Radic Biol Med. 2011 Sep 1;51(5):1062-7. doi: 10.1016/j.freeradbiomed.2010.10.704. Epub 2010 Oct 27. Free Radic Biol Med. 2011. PMID: 21034813 Free PMC article. Review.
-
Adverse effects of the renal accumulation of haem proteins. Novel therapeutic approaches.Nefrologia (Engl Ed). 2018 Jan-Feb;38(1):13-26. doi: 10.1016/j.nefro.2017.05.009. Epub 2017 Jun 28. Nefrologia (Engl Ed). 2018. PMID: 28668175 Review. English, Spanish.
Cited by
-
Assessment of rhabdomyolysis-induced acute kidney injury with chemical exchange saturation transfer magnetic resonance imaging.Quant Imaging Med Surg. 2023 Dec 1;13(12):8336-8349. doi: 10.21037/qims-23-699. Epub 2023 Oct 19. Quant Imaging Med Surg. 2023. PMID: 38106319 Free PMC article.
-
Codonopsis lanceolata Extract Restores Smooth Muscle Vasorelaxation in Rat Carotid Arteries Even under High Extracellular K+ Concentrations.Nutrients. 2023 Aug 30;15(17):3791. doi: 10.3390/nu15173791. Nutrients. 2023. PMID: 37686823 Free PMC article.
-
Renal iron accumulation occurs in lupus nephritis and iron chelation delays the onset of albuminuria.Sci Rep. 2017 Oct 9;7(1):12821. doi: 10.1038/s41598-017-13029-4. Sci Rep. 2017. PMID: 28993663 Free PMC article.
-
Iron and Cadmium Entry Into Renal Mitochondria: Physiological and Toxicological Implications.Front Cell Dev Biol. 2020 Sep 2;8:848. doi: 10.3389/fcell.2020.00848. eCollection 2020. Front Cell Dev Biol. 2020. PMID: 32984336 Free PMC article. Review.
-
Renal Function Recovery Strategies Following Marathon in Amateur Runners.Front Physiol. 2022 Feb 28;13:812237. doi: 10.3389/fphys.2022.812237. eCollection 2022. Front Physiol. 2022. PMID: 35295572 Free PMC article.
