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. 2012 Nov;57(6):504.
doi: 10.4103/0019-5154.103089.

Syphilis of Fungal world: Novel Skin Manifestations of Histoplasmosis in an Immunocompetent Host

Khader Anza  1 , George Mamatha, George Sandhya, Rajan Uma, Kunnummal Muhammed
Affiliations

Syphilis of Fungal world: Novel Skin Manifestations of Histoplasmosis in an Immunocompetent Host

Khader Anza et al. Indian J Dermatol. 2012 Nov.

Abstract

A case of chronic disseminated cutaneous histoplasmosis with unusual skin manifestations in an immunocompetent host is reported. Presence of cutaneous ulcers, linear erythematous plaques, skin coloured atrophic plaques and recurrent self-limiting oral ulcers in a single patient has not been documented in literature so far. Diagnosis was established by identifying small intracellular yeast-like cells of Histoplasma in tissue smear and skin biopsy. Leishman stained tissue smear proves to be an easy and simple procedure for diagnosis of histoplasmosis.

Keywords: Histoplasmosis; itraconazole; tissue smear.

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Conflict of interest statement

Conflict of Interest: Nil.

Figures

Figure 1
Figure 1
Varied morphological lesions: (a) Ulcerated plaques of varying size over forehead, periorbital area and cheeks; (b) Linear erythematous plaques over upper chest and crusted lesions over anterior axillary fold; (c) Atrophic plaques over thigh; (d) Linear atrophic plaque forearm
Figure 2
Figure 2
Tissue smears from ulcers and erythematous crusted plaques showing budding organism with peripheral halo. (Leishman stain, ×400)
Figure 3
Figure 3
Histology showing (a) Heavy dermal inflammatory infiltrate containing poorly formed granulomas and many giant cells, Hematoxylin and eosin stain, original magnification ×40; (b) Intracellular and extracellular yeast-like organisms with a surrounding halo, GMS stain, original magnification ×100
Figure 4
Figure 4
Healed lesions after 6 weeks of antifungal therapy
See this image and copyright information in PMC

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