Review
doi: 10.1038/nri2455.
Origin, homeostasis and function of Langerhans cells and other langerin-expressing dendritic cells
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- PMID: 19029989
- DOI: 10.1038/nri2455
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Review
Origin, homeostasis and function of Langerhans cells and other langerin-expressing dendritic cells
Nat Rev Immunol.
2008 Dec.
Abstract
Langerhans cells (LCs) are a specialized subset of dendritic cells (DCs) that populate the epidermal layer of the skin. Langerin is a lectin that serves as a valuable marker for LCs in mice and humans. In recent years, new mouse models have led to the identification of other langerin(+) DC subsets that are not present in the epidermis, including a subset of DCs that is found in most non-lymphoid tissues. In this Review we describe new developments in the understanding of the biology of LCs and other langerin(+) DCs and discuss the challenges that remain in identifying the role of different DC subsets in tissue immunity.
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