. 2008 Jun;47(6):642-651.

doi: 10.1097/CHI.0b013e31816bffb7.

A replication of the Autism Diagnostic Observation Schedule (ADOS) revised algorithms

Katherine Gotham¹, Susan Risi², Geraldine Dawson², Helen Tager-Flusberg², Robert Joseph², Alice Carter², Susan Hepburn², William McMAHON², Patricia Rodier², Susan L Hyman², Marian Sigman², Sally Rogers², Rebecca Landa², M Anne Spence², Kathryn Osann², Pamela Flodman², Fred Volkmar², Eric Hollander², Joseph Buxbaum², Andrew Pickles², Catherine Lord²

Affiliations

¹ Ms. Gotham and Drs. Risi and Lord are with the University of Michigan Autism and Communication Disorders Center; Dr. Dawson is with the University of Washington; Drs. Tager-Flusberg and Joseph are with Boston University School of Medicine; Dr. Carter is with the University of Massachusetts; Dr. Hepburn is with University of Colorado Health Sciences Center; Dr. McMahon is with the University of Utah; Drs. Rodier and Hyman are with University of Rochester Medical Center; Dr. Sigman is with University of California, Los Angeles; Dr. Rogers is with the University of California, Davis M.I.N.D. Institute; Dr. Landa is with Kennedy Krieger Institute; Drs. Spence and Osann and Ms. Flodman are with University of California, Irvine; Dr. Volkmar is with the Yale Child Study Center; Drs. Hollander and Buxbaum are with the Mount Sinai School of Medicine; and Dr. Pickles is with the University of Manchester.. Electronic address: kog@umich.edu.
² Ms. Gotham and Drs. Risi and Lord are with the University of Michigan Autism and Communication Disorders Center; Dr. Dawson is with the University of Washington; Drs. Tager-Flusberg and Joseph are with Boston University School of Medicine; Dr. Carter is with the University of Massachusetts; Dr. Hepburn is with University of Colorado Health Sciences Center; Dr. McMahon is with the University of Utah; Drs. Rodier and Hyman are with University of Rochester Medical Center; Dr. Sigman is with University of California, Los Angeles; Dr. Rogers is with the University of California, Davis M.I.N.D. Institute; Dr. Landa is with Kennedy Krieger Institute; Drs. Spence and Osann and Ms. Flodman are with University of California, Irvine; Dr. Volkmar is with the Yale Child Study Center; Drs. Hollander and Buxbaum are with the Mount Sinai School of Medicine; and Dr. Pickles is with the University of Manchester.

PMID: 18434924
PMCID: PMC3057666
DOI: 10.1097/CHI.0b013e31816bffb7

A replication of the Autism Diagnostic Observation Schedule (ADOS) revised algorithms

Katherine Gotham et al. J Am Acad Child Adolesc Psychiatry. 2008 Jun.

. 2008 Jun;47(6):642-651.

doi: 10.1097/CHI.0b013e31816bffb7.

Authors

Affiliations

¹ Ms. Gotham and Drs. Risi and Lord are with the University of Michigan Autism and Communication Disorders Center; Dr. Dawson is with the University of Washington; Drs. Tager-Flusberg and Joseph are with Boston University School of Medicine; Dr. Carter is with the University of Massachusetts; Dr. Hepburn is with University of Colorado Health Sciences Center; Dr. McMahon is with the University of Utah; Drs. Rodier and Hyman are with University of Rochester Medical Center; Dr. Sigman is with University of California, Los Angeles; Dr. Rogers is with the University of California, Davis M.I.N.D. Institute; Dr. Landa is with Kennedy Krieger Institute; Drs. Spence and Osann and Ms. Flodman are with University of California, Irvine; Dr. Volkmar is with the Yale Child Study Center; Drs. Hollander and Buxbaum are with the Mount Sinai School of Medicine; and Dr. Pickles is with the University of Manchester.. Electronic address: kog@umich.edu.
² Ms. Gotham and Drs. Risi and Lord are with the University of Michigan Autism and Communication Disorders Center; Dr. Dawson is with the University of Washington; Drs. Tager-Flusberg and Joseph are with Boston University School of Medicine; Dr. Carter is with the University of Massachusetts; Dr. Hepburn is with University of Colorado Health Sciences Center; Dr. McMahon is with the University of Utah; Drs. Rodier and Hyman are with University of Rochester Medical Center; Dr. Sigman is with University of California, Los Angeles; Dr. Rogers is with the University of California, Davis M.I.N.D. Institute; Dr. Landa is with Kennedy Krieger Institute; Drs. Spence and Osann and Ms. Flodman are with University of California, Irvine; Dr. Volkmar is with the Yale Child Study Center; Drs. Hollander and Buxbaum are with the Mount Sinai School of Medicine; and Dr. Pickles is with the University of Manchester.

PMID: 18434924
PMCID: PMC3057666
DOI: 10.1097/CHI.0b013e31816bffb7

Abstract

Objective: To replicate the factor structure and predictive validity of revised Autism Diagnostic Observation Schedule algorithms in an independent dataset (N = 1,282).

Method: Algorithm revisions were replicated using data from children ages 18 months to 16 years collected at 11 North American sites participating in the Collaborative Programs for Excellence in Autism and the Studies to Advance Autism Research and Treatment.

Results: Sensitivities and specificities approximated or exceeded those of the old algorithms except for young children with phrase speech and a clinical diagnosis of pervasive developmental disorders not otherwise specified.

Conclusions: Revised algorithms increase comparability between modules and improve the predictive validity of the Autism Diagnostic Observation Schedule for autism cases compared to the original algorithms.

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References

1. Gotham K, Risi S, Pickles A, Lord C. The Autism Diagnostic Observation Schedule (ADOS): revised algorithms for improved diagnostic validity. J Autism Dev Disord. 2007;37:400–408. - PubMed
1. Lord C, Risi S, Lambrecht L, et al. The Autism Diagnostic Observation Schedule–Generic: a standard measure of social and communication deficits associated with the spectrum of autism. J Autism Dev Disord. 2000;30:205–223. - PubMed
1. Joseph RM, Tager-Flusberg H, Lord C. Cognitive profiles and social-communicative functioning in children with autism spectrum disorders. J Child Psychol Psychiatry. 2002;43:807–821. - PMC - PubMed
1. de Bildt A, Sytema S, Ketelaars C, et al. Interrelationship between Autism Diagnostic Observation Schedule–Generic (ADOS-G), Autism Diagnostic Interview-Revised (ADI-R), and the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV-TR) classification in children and adolescents with mental retardation. J Autism Dev Disord. 2004;34:129–137. - PubMed
1. Lord C, Rutter M, DiLavore P, Risi S. Autism Diagnostic Observation Schedule Manual. Los Angeles: Western Psychological Services; 1999.

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A replication of the Autism Diagnostic Observation Schedule (ADOS) revised algorithms

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A replication of the Autism Diagnostic Observation Schedule (ADOS) revised algorithms

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