Plasma cell differentiation and the unfolded protein response intersect at the transcription factor XBP-1
- PMID: 12612580
- DOI: 10.1038/ni907
Plasma cell differentiation and the unfolded protein response intersect at the transcription factor XBP-1
Erratum in
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Author Correction: Plasma cell differentiation and the unfolded protein response intersect at the transcription factor XBP-1.Nat Immunol. 2024 May;25(5):928. doi: 10.1038/s41590-024-01827-8. Nat Immunol. 2024. PMID: 38600358 No abstract available.
Abstract
The transcription factor X-box binding protein 1 (XBP-1) is essential for the differentiation of plasma cells and the unfolded protein response (UPR). Here we show that UPR-induced splicing of XBP-1 by the transmembrane endonuclease IRE1 is required to restore production of immunoglobulin in XBP-1-/- mouse B cells, providing an integral link between XBP-1, the UPR and plasma cell differentiation. Signals involved in plasma cell differentiation, specifically interleukin-4, control the transcription of XBP-1, whereas its post-transcriptional processing is dependent on synthesis of immunoglobulins during B cell differentiation. We also show that XBP-1 is involved in controlling the production of interleukin-6, a cytokine that is essential for plasma cell survival. Thus, signals upstream and downstream of XBP-1 integrate plasma cell differentiation with the UPR.
Comment in
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The stressful road to antibody secretion.Nat Immunol. 2003 Apr;4(4):310-1. doi: 10.1038/ni0403-310. Nat Immunol. 2003. PMID: 12660729 No abstract available.
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