Production went through 3 different make-up effects artist. The first dropped out 6 weeks before production. The second was fired after 3 weeks of filming. The third stayed on till completion. Digital masking had to be added to fix make-up in post-production prolonging post for more than a year.
"Night of the STD's" was the original title.
Due to post-production fixes and budget constraints, and numerous delays due to Jonathan Straiton's chronic flatulence, the film took almost four years to complete.
The Blob, Night of the Creeps, and Evil Dead 2 were heavy influences when writing Night of Something Strange.
Script was written using crayons and construction paper in 2009.