46 wins & 88 nominations
1990 Nominee American Comedy Award- Funniest Female Performer in a TV Series (Leading Role) Network, Cable or Syndication
- 1987 Winner American Comedy Award
- Funniest Female Performer in a TV Series (Leading Role) Network, Cable or Syndication
1987 Nominee American Comedy Award- Funniest Female Performer in a TV Series (Leading Role) Network, Cable or Syndication
1988 Nominee DGA Award- Outstanding Directorial Achievement in Comedy Series
For episode "Old Friends".- 1987 Winner DGA Award
- Outstanding Directorial Achievement in Comedy Series
- Terry Hughes
- Gary Shimokawa (associate director) (plaque)
- Lex Passaris (associate director) (plaque)
- Tom Carpenter (stage manager) (plaque)
- Jane Greene (stage manager) (plaque)
- Robert Spina (production associate) (plaque)
- Ellen Deutsch (production associate) (plaque)
For episode "Isn't It Romantic?". - 1986 Winner DGA Award
- Outstanding Directorial Achievement in Comedy Series
- Jay Sandrich
- Harry Waterson (unit production manager) (plaque)
- Gary Shimokawa (associate director) (plaque)
- Tom Carpenter (stage manager) (plaque)
- Doug Tobin (stage manager) (plaque)
- Laurie Gilbert (production assistant) (plaque)
- 1992 Nominee Primetime Emmy
- Outstanding Supporting Actress in a Comedy Series
For playing: "Sophia Petrillo". 
1992 Winner Primetime Emmy- Outstanding Technical Direction/Camera/Video for a Series
- Ken Tamburri (technical director)
- Ritch Kenney (camera operator)
- Stephen A. Jones (camera operator)
- Dave Heckman (camera operator)
- Chester Jackson (camera operator)
- Bob Keys (camera operator)
- Randy Johnson (video control)
- Richard Steiner (video control)
- John O'Brien (video control)
For episode "One Flew Out Of The Cuckoo's Nest", parts I and II.
1991 Nominee Primetime Emmy- Outstanding Comedy Series
- Paul Junger Witt (executive producer)
- Tony Thomas (executive producer)
- Susan Harris (executive producer)
- Marc Sotkin (executive producer)
- Tom Whedon (co-executive producer)
- Phillip Jayson Lasker (co-executive producer)
- Gail Parent (supervising producer)
- Richard Vaczy (supervising producer)
- Tracy Gamble (supervising producer)
- Don Seigel (supervising producer)
- Jerry Perzigian (supervising producer)
- Nina Feinberg (co-producer)
1991 Nominee Primetime Emmy- Outstanding Guest Actress in a Comedy Series
For playing "Angela Petrillo". For episode "Ebbtide's Revenge".
- 1992 Nominee Golden Globe
- Best Television Series - Comedy or Musical
- 1992 Nominee Golden Globe
- Best Performance by an Actress in a Supporting Role in a Series, Miniseries or Motion Picture Made for Television
- 1991 Nominee Golden Globe
- Best Television Series - Comedy or Musical
- 1990 Nominee Golden Globe
- Best Television Series - Comedy or Musical
- 1989 Nominee Golden Globe
- Best Television Series - Comedy or Musical
- 1986 Winner People's Choice Award
- Favorite New TV Comedy Program
1989 Winner Special Achievement Award- Television and Theatrical Film Fiction
- Susan Harris (executive)
- Paul Junger Witt (executive)
- Tony Thomas (executive)
- 1986 Nominee TCA Award
- Outstanding Achievement in Comedy
- 1988 Nominee Q Award
- Best Quality Comedy Series
1987 Nominee WGA Award (TV)- Episodic Comedy
For Blanche and the Younger Man (1985). AKA "Rose's Mother".
1992 Nominee Young Artist Award- Best Young Actress Guest Starring or Recurring Role in a TV Series
1989 Nominee Young Artist Award- Best Young Actress Guest Starring in a Drama or Comedy Series
1987 Winner Young Artist Award- Exceptional Performance by a Young Actor, Guest Starring in a Television, Comedy or Drama Series
- 1989 Winner TP de Oro
- Best Foreign Series (Mejor Serie Extranjera)
- 2003 Winner TV Land Award
- Quintessential Non-Traditional Family
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