- Younger brother of actor Rob Lowe.
- Won an Emmy for his portrayal of AIDS sufferer Jesse McKenna on the TV series Life Goes On (1989).
- His girlfriend, Kim Painter, was Carrie Fisher's personal assistant.
- Married film producer Kim Painter in an intimate oceanside ceremony at Terranea Resort in Los Angeles on Saturday, August 28, 2010. Chad's brother, Rob Lowe, was best man, while the pair's 15-month-old daughter, Mabel, served as ring bearer.
- (9th January 2006) Announced separation from his wife Hilary Swank.
- He and then-girlfriend, Kim Painter, became the parents of a daughter, Mabel Painter-Lowe, on May 16th, 2009 in Los Angeles. Since their marriage, they became parents to two additional daughters, Fiona Hepler Lowe November 15th, 2012, and Nixie Barbara Lowe on March 18th, 2016.
- While on location with Hilary in Vancouver in early 2002 for her role in The Core (2003), Chad wrote and shot his own 21-minute psycho-thriller short called The Space Between (2002), in which Hilary contributed a small role.
- He has German, along with smaller amounts of English, Irish, Welsh, and Scottish, ancestry.
- 2 younger half-brothers: Justin W. Lowe and Micah Dyer.
- Brother-in-law of makeup artist Sheryl Berkoff.
- Auditioned to be one of the basketball players in Hoosiers (1986).
- Announced that he and his wife, Kim Painter, are expecting their 2nd child this fall [2012].
- Ex-son-in-law of Judy Swank.
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