Smith Family
Stan Smith | Roger Smith (Ricky Spanish, Martin Sugar, & Dudley Dingleberry) | Klaus Heissler | Jack Smith | Betty Smith

Recurring Characters/Guest Star Characters
Avery Bullock | Brian Lewis | Santa Claus | Memphis Stormfront | The Devil | Lorraine | Barry Robinson | Nemo the Anti-Christ | Henry | Black Villain | Steve-arino | Stelio Kontos | Roy Family | Nicholas and Cassandra Dawson | Randy | Buckle the Mountain Man | Phillip | Hiko Yoshida | Tearjerker | Hot Tub | Tracey Bryant | Chaz Migliaco | Goran the Mutilator | Emperor Zing | Christie White | Foster | Dusty Baker | Luis Ramirez | June Rosewood | Alistair Covax | Artemis | Gina | Phyllis | Holly Graham | Nurse Jocelyn | Dr. Constance and Wilhelm von Stroheim | Morbo | The Falcon | The RB Killer | Nat | Scarlett Reynolds | The Poltergazm | Common Garden Snake of Rumallah | Cuddles | Belgian Terrorist | Bobby the Bullet | Man Stroking Cat A Menacingly | Butch Johnson | Dan Vebber | Demetrious Pertz | Donnie | Fernando Jaramillo | Johnny Concussion | Hank Henderson | Henry Fischer | Jimmy Carter | Meg Penner | Malcolm Hathaway | Jim | Ernie | Stanferatu | Future Cyborg Stan Smith | B'thazalom the Nameless One | Avery Bullock, Sr. | Toad-Button | Charles Guiteau Clone | Mrs. Claus

Groups & Organizations
The Police of Vice and Virtue | Pirate Cats | McKennon Foundation | Crow People | Bahamian Drug Gang | The Dawson Family | The Collectors | Exotic Food Club | Eco-Warriors | Handicapped Mafia | Warehouse Drug Gang | Hogwarts Drug Gang | Appalachian Trail Chop Shop Candy Gang | Crazy Lake People | The Order of the Hand and Nest | Ladybugs | Magillicutty Gang | Bowango Rebels | Michell and Webb Beauty Glam-Bam Sales Force | The Chinese Mafia | Loan Sharks | Hall Monitors

See Also
Family Guy Villains | The Cleveland Show Villains