Hamilton Smith was a professor of alien-human interaction and integration at St Oscar's University. He had theories on the Chelonians, Krakenites, Valethske, Xarax, Tzun, Tractites, Oblongooni, and Saraani. (PROSE: Dry Pilgrimage)

Working at the Braxiatel Collection, Bernice Summerfield once remarked that Ovmakh would get on well with Smith. (PROSE: Mentioning the War)

While meeting the Fifth Doctor, Aline Vehlmann mentioned she was making a paper on the Eknuri for the Hamilton Smith Institute. (PROSE: Superior Beings)

Several centuries after Smith's era, his work inspired Arielle Martha Urn to study xenobiology at the University of Yquatine. She told Fitz Kreiner that Smith was "a brilliant man" who "published the definitive work on alien-human interaction". (PROSE: The Fall of Yquatine)