Clotho was the first of the Fates, the three sisters who ruled the destiny of mortals. Her function was to spin the threads of their lives.

Before the Doctor was born, Clotho spun the cords of his life, placed her hand on his mother's swollen belly, and ran her fingers through her red hair. She found the Doctor's mother beautiful. When the Doctor was born, Clotho determined his fate, which was to be curious in all things.

When the universe was ravaged by a war between gods, such as the Olympians and the Osirans, Clotho and her sisters protected endangered worlds by removing them from the universe and storing them temporarily inside impermeable crystal spheres. (PROSE: The Spindle of Necessity)

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