GPRC5B
| G protein spregnuti receptor, familija C, grupa 5, član B | |||||||||||
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| Identifikatori | |||||||||||
| Simboli | GPRC5B; RAIG-2; RAIG2 | ||||||||||
| Vanjski ID | OMIM: 605948 MGI: 1927596 HomoloGene: 9435 IUPHAR: RAIG2 GeneCards: GPRC5B Gene | ||||||||||
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| Pregled RNK izražavanja | |||||||||||
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| Ortolozi | |||||||||||
| Vrsta | Čovek | Miš | |||||||||
| Entrez | 51704 | 64297 | |||||||||
| Ensembl | ENSG00000167191 | ENSMUSG00000008734 | |||||||||
| UniProt | Q9NZH0 | Q923Z0 | |||||||||
| RefSeq (mRNA) | NM_016235.1 | NM_001195774.1 | |||||||||
| RefSeq (protein) | NP_057319.1 | NP_001182703.1 | |||||||||
| Lokacija (UCSC) |
Chr 16: 19.87 - 19.9 Mb |
Chr 7: 126.12 - 126.14 Mb | |||||||||
| PubMed pretraga | [1] | [2] | |||||||||
G protein spregnuti receptor, familija C, grupa 5, član B je protein koji je kod ljudi kodiran GPRC5B genom.[1][2][3]
Ovaj protein pripada familiji tipa 3 G protein spregnutih receptora, koja ima karakteristični 7-transmembranski domen. On potencijalno učestvuje u interakciji između retinoidne kiseline i G protein signalnih puteva. Retinoinska kiselina ima kritičnu ulogu u razvoju, ćelijskom rastu, i diferencijaciji. Ovaj gen potencijalno učestvuje u embrionskom razvoju i diferencijaciji epitelnih ćelija.[3]
Reference
[uredi | uredi izvor]- ^ Loftus BJ, Kim UJ, Sneddon VP, Kalush F, Brandon R, Fuhrmann J, Mason T, Crosby ML, Barnstead M, Cronin L, Deslattes Mays A, Cao Y, Xu RX, Kang HL, Mitchell S, Eichler EE, Harris PC, Venter JC, Adams MD (1999). „Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q”. Genomics. 60 (3): 295—308. PMID 10493829. doi:10.1006/geno.1999.5927.
- ^ Brauner-Osborne H, Krogsgaard-Larsen P (2000). „Sequence and expression pattern of a novel human orphan G-protein-coupled receptor, GPRC5B, a family C receptor with a short amino-terminal domain”. Genomics. 65 (2): 121—8. PMID 10783259. doi:10.1006/geno.2000.6164.
- ^ а б „Entrez Gene: GPRC5B G protein-coupled receptor, family C, group 5, member B”.
Literatura
[uredi | uredi izvor]- Robbins MJ; Michalovich D; Hill J; et al. (2001). „Molecular cloning and characterization of two novel retinoic acid-inducible orphan G-protein-coupled receptors (GPRC5B and GPRC5C)”. Genomics. 67 (1): 8—18. PMID 10945465. doi:10.1006/geno.2000.6226.
- Strausberg RL; Feingold EA; Grouse LH; et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899—903. PMC 139241
. PMID 12477932. doi:10.1073/pnas.242603899. - Ota T; Suzuki Y; Nishikawa T; et al. (2004). „Complete sequencing and characterization of 21,243 full-length human cDNAs”. Nat. Genet. 36 (1): 40—5. PMID 14702039. doi:10.1038/ng1285.
- Gerhard DS; Wagner L; Feingold EA; et al. (2004). „The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)”. Genome Res. 14 (10B): 2121—7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
- Otsuki T; Ota T; Nishikawa T; et al. (2007). „Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries”. DNA Res. 12 (2): 117—26. PMID 16303743. doi:10.1093/dnares/12.2.117.
Vidi još
[uredi | uredi izvor]Spoljašnje veze
[uredi | uredi izvor]- „GPRC5 Receptors: RAIG2”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Архивирано из оригинала 08. 08. 2014. г.